5 recruiting, 4 completed, 4 unknown, 1 active not recruiting. 9 Phase 2, 7 Phase 1, 2 Not applicable, 1 Phase 3.
Follow Soft-Tissue Sarcoma: new trials by email Literature Review of Soft-Tissue Sarcoma trials Research Report on Soft-Tissue Sarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue Sarcoma Zanzalintinib, Pembrolizumab - Phase 2, Zanzalintinib | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 20 | 2026-04-14 | 2026-11-02 |
| Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies Spedox-6, Pegfilgrastim, Filgrastim - Soft-tissue Sarcoma, Triple Negative Breast Cancer | Phase 1 / Phase 2 | Recruiting | University of California, Irvine | 67 | 2025-04-30 | 2026-07-17 |
| INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients Incisional Negative Pressure Wound Therapy (INPWT), Wound Dressing - Soft-tissue Sarcoma, Wound Complication | Not applicable | Recruiting | Dr. J. Werier | 291 | 2022-02-01 | 2026-03-02 |
| The Value of a Risk Prediction Tool (PERSARC) for Effective Treatment Decisions of Soft-tissue Sarcomas Patients Care with the use of PERSARC, standard care - Soft-tissue Sarcoma, Predictive Cancer Model | Not applicable | Active not recruiting | Leiden University Medical Center | 120 | 2021-08-24 | 2025-09-09 |
| Observational Study, for Quality Assessment, of Sarcoma in European and Latin American Multidisciplinary NETWORK Quality assessment - Soft-tissue Sarcoma, Gastrointestinal Stromal Tumors | Recruiting | Grupo Espanol de Investigacion en Sarcomas | 5000 | 2019-06-30 | 2025-03-21 | |
| Phase I Study Compound 451238 and Radiotherapy in Soft-tissue Sarcoma Compound 451238 - Soft-tissue Sarcoma | Phase 1 / Phase 2 | Completed | Royal Marsden NHS Foundation Trust | 12 | 2018-11-05 | 2026-03-02 |
| A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors Phase 1 : Regorafenib, Phase 1 : Avelumab, Phase 2 : Regorafenib - Colorectal Cancer Not MSI-H or MMR-deficient, GIST | Phase 1 / Phase 2 | Unknown | Institut Bergonié | 747 | 2018-05-04 | 2023-03-03 |
| Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild Hyperthermia Magnetic Resonance-guided High-Intensity Focused Ultrasound - Healthy Participants, Pelvic Neoplasms | Phase 1 | Withdrawn | Washington University School of Medicine | 2017-09-30 | 2017-10-06 | |
| Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS) AL3818, Dacarbazine, AL3818 or placebo - Alveolar Soft Part Sarcoma, Leiomyosarcoma | Phase 3 | Recruiting | Advenchen Laboratories, LLC | 325 | 2017-08-15 | 2026-02-25 |
| Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. Palbociclib - Soft-tissue Sarcoma, Osteosarcoma | Phase 2 | Unknown | Grupo Espanol de Investigacion en Sarcomas | 40 | 2017-03-31 | 2024-01-23 |
| Study of TAK-228 (MLN0128) in Soft Tissue Sarcomas TAK-228 - Soft-tissue Sarcoma | Phase 2 | Terminated | Fox Chase Cancer Center | 6 | 2017-02-21 | 2022-10-14 |
| A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Ribociclib - Liposarcomas, Dedifferentiated, Liposarcoma - Well Differentiated | Phase 2 | Unknown | Assaf-Harofeh Medical Center | 30 | 2016-07-01 | 2017-10-25 |
| A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma Olaparib, Concomitant Radiotherapy - Soft-tissue Sarcoma | Phase 1 | Completed | Institut Bergonié | 41 | 2016-01-01 | 2026-02-25 |
| A Study of Metronomic CP and JX-594 in Patients With Advanced Breast Cancer and Advanced Soft-tissue Sarcoma (METROmaJX) Cyclophosphamide and JX-594 dose escalation, Cyclophosphamide and JX-594, Cyclophosphamide - Solid Tumors, Soft-tissue Sarcoma | Phase 1 / Phase 2 | Unknown | Institut Bergonié | 197 | 2015-09-18 | 2022-02-02 |
| Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma Pazopanib, GSK1120212 - Solid Tumors, Thyroid Cancer | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 89 | 2011-10-01 | 2018-08-29 |
| High Precision RT For Soft-Tissue Sarcoma Intensity-Modulated Radiotherapy, Daily Cone Beam CT - Soft-Tissue Sarcoma | Phase 2 | Completed | University Health Network, Toronto | 26 | 2011-06-01 | 2022-10-07 |
Sarcoma (16) · Carcinoma, Non-Small-Cell Lung (2) · Neoplasm Metastasis (2) · Thyroid Neoplasms (2) · Triple Negative Breast Neoplasms (2) · Uterine Cervical Neoplasms (2) · Biliary Tract Neoplasms (1) · Bone Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Renal Cell (1) · Carcinoma, Transitional Cell (1) · Cholangiocarcinoma (1) · Chordoma (1) · Gastro-enteropancreatic neuroendocrine tumor (1)
Neoplasms (16) · Neoplasms by Histologic Type (16) · Neoplasms, Connective and Soft Tissue (16) · Neoplasms by Site (6) · Breast Diseases (3) · Digestive System Diseases (3) · Digestive System Neoplasms (3) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Gastrointestinal Diseases (3) · Gastrointestinal Neoplasms (3) · Neoplasms, Connective Tissue (3) · Skin Diseases (3)
Bandages (1) · Clinical Trials, Phase II as Topic (1) · Cyclophosphamide (1) · Dacarbazine (1) · Digoxin (1) · Filgrastim (1) · Midazolam (1) · Quality Assurance, Health Care (1) · Radiotherapy, Intensity-Modulated (1) · Rosuvastatin Calcium (1) · Standard of Care (1) · Tablets (1) · anlotinib (1) · avelumab (1) · olaparib (1)
Institut Bergonié (3) · Grupo Espanol de Investigacion en Sarcomas (2) · Advenchen Laboratories, LLC (1) · Assaf-Harofeh Medical Center (1) · Dr. J. Werier (1) · Fox Chase Cancer Center (1) · Leiden University Medical Center (1) · M.D. Anderson Cancer Center (1) · Royal Marsden NHS Foundation Trust (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · University Health Network, Toronto (1) · University of California, Irvine (1) · Washington University School of Medicine (1)
United States (5) · France (4) · Spain (3) · Canada (2) · Italy (2) · United Kingdom (2) · Argentina (1) · Brazil (1) · China (1) · Costa Rica (1) · Israel (1) · Mexico (1) · Netherlands (1) · Peru (1)
Anna Estival (1) · Antonio Casado (1) · Charles Catton, MD (1) · Claudia Valverde (1) · Daniela Katz, M.D (1) · Diego Jara, MD (1) · Isabel Sevilla, MD (1) · Javier Lavernia (1)
PMID 32827353, PMID 34965951, PMID 34998048, PMID 37918933, PMID 39894354, PMID 40204996, PMID 40579407, PMID 41023919
2014 (1), 2015 (1), 2016 (1), 2017 (1)