178 completed, 12 recruiting, 9 unknown, 5 active not recruiting. 162 Phase 1, 20 Phase 2, 14 Not applicable, 12 Phase 4, 9 Phase 3.
Follow Digoxin: new trials by email Literature Review of Digoxin trials Research Report on Digoxin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| An Open-label DDI Study to Investigate the Effect of Rilzabrutinib on P-gp, BCRP, OATP1B1 and OATP1B3 Inhibition Rilzabrutinib, Rosuvastatin, Digoxin - Healthy Volunteer | Phase 1 | Active not recruiting | Sanofi | 14 | 2026-10-01 | 2026-10-21 |
| A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy Adults Itraconazole, Rifampicin, Omeprazole - Healthy Subjects | Phase 1 | Not yet recruiting | InventisBio Co., Ltd | 60 | 2026-09-16 | 2026-10-15 |
| Drug-Drug Interaction Study of Atumelnant in Healthy Participants Atumelnant, Carbamazepine, Midazolam - Healthy Volunteers | Phase 1 | Completed | Crinetics Pharmaceuticals Inc. | 46 | 2026-05-28 | 2026-08-19 |
| Phase I Drug-Drug Interaction Study of UBT251 Injection in Participants With Overweight or Obesity UBT251, Metformin hydrochloride, Warfarin Sodium - Drug Drug Interaction (DDI), Pharmacokinetics and Pharmacodynamics | Phase 1 | Recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 48 | 2026-05-27 | 2026-08-25 |
| Drug-drug Interaction Study of ZT002 Injection in Overweight and Obese Participants ZT002 injection, metformin, warfarin, ZT002 injection, rosuvastatin, digoxin - Overweight,Obesity | Phase 1 | Active not recruiting | Beijing QL Biopharmaceutical Co.,Ltd | 60 | 2026-05-27 | 2026-10-21 |
| Drug-Drug Interactions of JMKX003142 in Healthy Participants JMKX003142 tablets, Fluconazole Capsules, Cocktail Substrates (Midazolam Oral Solution, Rosuvastatin Calcium Tablets, and Digoxin Tablets) - ADPKD (Autosomal Dominant Polycystic Kidney Disease) | Phase 1 | Not yet recruiting | Jemincare | 112 | 2026-05-11 | 2026-05-04 |
| A Phase 1 Study to Assess the Effect of ABBV-722 on Midazolam, Digoxin, Pitavastatin, Metformin, and Sitagliptin Drug Levels in Healthy Adults. ABBV-722, Midazolam, Metformin - Healthy Volunteers | Phase 1 | Completed | AbbVie | 12 | 2026-04-30 | 2026-08-20 |
| Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin Acetaminophen, Metformin, Warfarin - Overweight, Obesity | Phase 1 | Not yet recruiting | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | 42 | 2026-04-08 | 2026-03-30 |
| Digoxin Medulloblastoma Study Digoxin - Medulloblastoma, Medulloblastoma, Non-WNT/Non-SHH | Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 23 | 2026-01-15 | 2026-11-04 |
| A Study of LY4515100 in Healthy Participants LY4515100 via SAD, LY4515100 via MAD, LY4515100 - Healthy | Phase 1 | Recruiting | Eli Lilly and Company | 209 | 2026-01-15 | 2026-11-05 |
| Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication Catheter Ablation for Atrial Fibrillation, Rate Control Medications (beta-blockers, calcium channel blockers, digoxin) - Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction | Not applicable | Recruiting | Nova Scotia Health Authority | 84 | 2026-01-01 | 2026-10-20 |
| Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants Repotrectinib, Metformin, Digoxin - Healthy Volunteers | Phase 1 | Completed | Bristol-Myers Squibb | 30 | 2025-12-31 | 2026-03-27 |
| Digoxin After Acute Heart Failure (DIG-DICA) Usual Care, Digoxin - Acute Heart Failure (AHF) | Phase 4 | Recruiting | Hospital General de Agudos "Dr. Cosme Argerich" | 120 | 2025-12-16 | 2026-06-02 |
| A Study to Evaluate the Drug Interactions of HRS-7535 With Acetaminophen, Digoxin, Rosuvastatin, and Omeprazole in Obese or Overweight Subjects HRS-7535 Tablets, Paracetamol Tablets, Digoxin Tablets - Obesity, Overweight | Phase 1 | Completed | Shandong Suncadia Medicine Co., Ltd. | 40 | 2025-12-07 | 2026-06-29 |
| A Study in Healthy People to Test Whether BI 3000202 Affects How 2 Other Medicines (Rosuvastatin and Digoxin) Are Taken up in the Body BI 3000202, Rosuvastatin, Digoxin - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 14 | 2025-11-05 | 2025-12-22 |
| A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin KarXT, Midazolam, Fexofenadine - Healthy Volunteers | Phase 1 | Completed | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 62 | 2025-09-29 | 2026-07-22 |
| Digoxin and Senolysis in Heart Failure and Diabetes Mellitus Digoxin 0.125 MG - Heart Failure, Systolic, Diabetes Mellitus, Type 2 | Phase 2 | Not yet recruiting | University of Leeds | 100 | 2025-09-01 | 2024-12-06 |
| Efficacy Study of Digoxin Combined With Serplulimab and Chemotherapy in First-Line Treatment of MSS Advanced Colorectal Cancer Digoxin, Fuquinitinib, Tislelizumab - Colorectal Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Fudan University | 20 | 2025-08-01 | 2025-08-01 |
| A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy Adults VH4524184, Itraconazole, Rifabutin - HIV Infections | Phase 1 | Completed | ViiV Healthcare | 126 | 2025-07-07 | 2026-03-09 |
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Atrial Fibrillation (17) · Heart Failure (10) · Diabetes Mellitus, Type 2 (9) · Obesity (7) · Overweight (7) · Arthritis, Rheumatoid (5) · Breast Neoplasms (4) · Diabetes Mellitus (4) · Neoplasms (4) · Arrhythmias, Cardiac (3) · Carcinoma, Non-Small-Cell Lung (3) · HIV Infections (3) · Heart Diseases (3) · Melanoma (3) · Non-alcoholic Fatty Liver Disease (3)
Boehringer Ingelheim (16) · Eli Lilly and Company (10) · AstraZeneca (8) · Bristol-Myers Squibb (8) · GlaxoSmithKline (4) · Novo Nordisk A/S (4) · Celgene (3) · Jiangsu HengRui Medicine Co., Ltd. (3) · Merck Sharp & Dohme LLC (3) · Sanofi (3) · University of Monastir (3) · University of Washington (3) · ViiV Healthcare (3) · Yale University (3) · Assistance Publique - Hôpitaux de Paris (2)
United States (95) · China (31) · Germany (22) · United Kingdom (13) · Canada (9) · Netherlands (9) · France (7) · Australia (6) · Spain (5) · Italy (4) · South Korea (4) · Sweden (4) · Belgium (3) · Japan (3) · Switzerland (3)
Arthur Frankel, MD (2) · Christoph Hornik, MD (2) · Giuseppe Cocco, MD (2)
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