161 unknown, 64 not yet recruiting, 48 completed, 45 recruiting. 264 Phase 2, 40 Phase 1, 30 Phase 3, 20 Not applicable, 12 Phase 4.
Follow this drug Literature Review of anlotinib trials Research Report on anlotinib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SBRT Plus Anlotinib and Bimepolizumab in Locally Advanced or Metastatic Renal Cell Carcinoma Stereotactic Body Radiation Therapy (SBRT), Anlotinib, Bemarituzumab - Locally Advanced or Metastatic Renal Cell Carcinoma | Phase 2 | Not yet recruiting | Fujian Cancer Hospital | 27 | 2027-02-01 | 2026-10-01 |
| MRD and Imaging Guided Adaptive Neoadjuvant Therapy for Resectable NSCLC PD-1 inhibitor, Carboplatin, Nab-paclitaxel - Non-Small Cell Lung Cancer (NSCLC) | Phase 2 | Not yet recruiting | Peking University People's Hospital | 100 | 2026-11-01 | 2026-10-21 |
| A Phase II Study of Anlotinib + PD-1 Inhibitor vs. PD-1 Inhibitor Maintenance After First-Line Chemoimmunotherapy in Advanced ESCC (Esophageal Squamous Cell Carcinoma) anlotinib + PD-1 inhibitor, PD-1 inhibitor - Esophageal Cancer (EC) | Phase 2 | Recruiting | Sun Yat-sen University | 112 | 2026-10-12 | 2026-10-07 |
| Cryoablation Combined With Anlotinib Plus TQB2868 in Patients With Advanced Intrahepatic Cholangiocarcinoma Anlotinib, TQB2868 Injection, cryoablation - Intrahepatic Cholangiocarcinoma | Phase 2 | Not yet recruiting | Fudan University | 56 | 2026-10-01 | 2026-09-29 |
| An Exploratory Clinical Study Of Bempemab Combined With Anlotinib As First-Line Treatment For Elderly Patients With Locally Advanced Or Metastatic Non-Small-Cell Lung Cancer Benmelstobart Combined With Anlotinib - Non-small Cell Lung Cancer (NSCLC) Stage IV, Locally Advanced Non-Small Cell Lung Cancer | Not applicable | Not yet recruiting | Zhejiang Cancer Hospital | 30 | 2026-10-01 | 2026-09-30 |
| The Study Of Andamertinib Plus Anlotinib In Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Andamertinib, Anlotinib - Non-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line | Phase 2 | Not yet recruiting | Fudan University | 34 | 2026-09-30 | 2026-08-25 |
| A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers AL58805, AL3818, Temozolomide (TMZ) - Endometrial Neoplasms, Ovarian Neoplasms | Phase 1 / Phase 2 | Not yet recruiting | Advenchen Pharmaceuticals, LLC. | 138 | 2026-09-01 | 2026-09-10 |
| Immunotherapy Plus Anlotinib After Surgery for Esophageal Squamous Cell Cancer With Residual Tumor and Positive Lymph Nodes Anlotinib, Anti-PD-1 Monoclonal Antibody - Esophageal Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Shanghai Chest Hospital | 75 | 2026-09-01 | 2026-09-21 |
| Culmerciclib Plus Anlotinib and Endocrine Therapy for HR-Positive/HER2-Negative Metastatic Breast Cancer With Brain Metastases Culmerciclib, Anlotinib, Endocrine Therapy - HR-positive, HER2-negative Metastatic Breast Cancer With Brain Metastases | Phase 2 | Not yet recruiting | Sun Yat-sen University | 40 | 2026-08-28 | 2026-08-04 |
| Toripalimab Combined With Beat Chemotherapy in the Treatment of Advanced Back-line Small Cell Lung Cancer Toripalimab; Etoposide - SCLC, Extensive Stage, Bayesian | Phase 2 | Not yet recruiting | Henan Cancer Hospital | 130 | 2026-08-01 | 2026-07-13 |
| A Single-arm, Exploratory Clinical Study Evaluating the Efficacy and Safety of Bevacizumab in Combination With Anlotinib and Etoposide as First-line Therapy for Elderly Patients With Small-cell Lung Cancer or Those Who Are Intolerant to Intensive Chemotherapy benmelstobart in combination with anlotinib and etoposide - Small Cell Lung Cancer ( SCLC ) | Phase 3 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 64 | 2026-08-01 | 2026-07-27 |
| QL1706 Plus Anlotinib as a Later-line Treatment for Patients With Advanced Lung Cancer QL1706, Anlotinib - Small Cell Lung Cancer | Phase 2 / Phase 3 | Not yet recruiting | Sun Yat-sen University | 120 | 2026-07-30 | 2026-06-09 |
| Preoperative Radiotherapy and Anlotinib With or Without Penpulimab for Soft Tissue Sarcoma Anlotinib, Penpulimab, Preoperative Radiotherapy - Soft Tissue Sarcoma (STS) | Phase 2 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 274 | 2026-07-01 | 2026-05-28 |
| A Phase 2 Study of Luvometinib Combined With Anlotinib in KRAS-mutated NSCLC luvometinib + anlotinib - Non-small Cell Lung Caner, KRAS-mutated | Phase 2 | Recruiting | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 48 | 2026-06-15 | 2026-09-02 |
| Exploratory Study on Toripalimab and Anlotinib Combined With Standard Chemotherapy for Refractory Dermatofibrosarcoma Protuberans Toripalimab, Anlotinib, Standard Chemotherapy - Dermatofibrosarcoma Protuberans (DFSP) | Phase 2 | Not yet recruiting | Yanjie Zhang, MD | 20 | 2026-06-15 | 2026-06-16 |
| Anlotinib+Cadonilimab+PULSAR in Advanced Biliary Tract Cancer Anlotinib + Cadonilimab, PULSAR - Previously Treated, Advanced, Biliary Tract Cancers | Phase 2 | Active not recruiting | West China Hospital | 26 | 2026-06-03 | 2026-06-09 |
| Neoadjuvant Anlotinib and Epirubicin for T4 Sinonasal Adenoid Cystic Carcinoma Anlotinib + Epirubicin - Adenoid Cystic Carcinoma | Phase 2 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 76 | 2026-06-01 | 2026-06-01 |
| Lomustine Combined With Anlotinib as Interventional Therapy for Extensive-stage Small Cell Lung Cancer Resistant to Second-line and Above Treatment Lomustine, Anlotinib - SCLC, Extensive Stage | Phase 2 | Not yet recruiting | Yayi He | 46 | 2026-06-01 | 2026-06-08 |
| Neoadjuvant PD-L1 Inhibitor Plus Anlotinib for Kidney Preservation in Complex Renal Cell Carcinoma TQB2450 + Anlotinib - Clear Cell Renal Cell Carcinoma | Phase 2 | Not yet recruiting | RenJi Hospital | 33 | 2026-05-31 | 2026-05-22 |
| Efficacy and Safety of Induction Benmelstobart Plus Anlotinib and Chemotherapy Followed by Concurrent Chemoradiotherapy and Benmelstobart Maintenance Versus Concurrent Chemoradiotherapy Followed by Benmelstobart Maintenance in Patients With Unresectable Stage III NSCLC Benmelstobart, benmelstobart combined with chemotherapy and anlotinib - NSCLC | Phase 2 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 152 | 2026-05-15 | 2026-06-11 |
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Carcinoma, Non-Small-Cell Lung (55) · Small Cell Lung Carcinoma (25) · Breast Neoplasms (18) · Sarcoma (18) · Carcinoma, Hepatocellular (10) · Esophageal Squamous Cell Carcinoma (10) · Lung Neoplasms (10) · Neoplasm Metastasis (8) · Neoplasms (8) · Ovarian Neoplasms (8) · Stomach Neoplasms (8) · Esophageal Neoplasms (7) · Nasopharyngeal Carcinoma (7) · Triple Negative Breast Neoplasms (7) · Thyroid Neoplasms (6)
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (41) · Sun Yat-sen University (20) · Fudan University (14) · The First Affiliated Hospital with Nanjing Medical University (13) · Shanghai Chest Hospital (12) · Tianjin Medical University Cancer Institute and Hospital (11) · Zhejiang Cancer Hospital (10) · Henan Cancer Hospital (9) · Peking Union Medical College Hospital (9) · Nanfang Hospital, Southern Medical University (6) · Tang-Du Hospital (6) · Hunan Cancer Hospital (5) · Advenchen Laboratories, LLC (4) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (4) · Chinese Academy of Medical Sciences (4)
China (278) · United States (5) · Italy (2) · Spain (2) · United Kingdom (2) · South Korea (1)
Yuankai Shi, MD (3) · Anli Tong (2) · Dingzhi Huang, Doctor (2) · Jieer Ying (2) · Jinwan Wang, doctor (2) · Juan Du (2) · Peng Yuan (2) · Yan Zhang, M.D. (2) · Yihebali Chi, doctor (2) · Yongchang Zhang (2) · Yongchang Zhang, MD (2) · Yongqian Shu, PhD (2) · Aiping Zhou (1) · Aiqin Gu, Chief physician (1)
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