17 completed, 5 recruiting, 4 not yet recruiting, 1 active not recruiting. 16 Not applicable, 2 Phase 1, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 9, Recruiting 4, Not yet recruiting 2, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Salivary Flow, pH, and Buffering Capacity in Fixed and Clear Aligner Orthodontic Treatment Fixed orthodontic appliances, Clear Aligner Treatment - Orthodontic Treatment, Saliva | Not applicable | Not yet recruiting | Riyadh Elm University | 40 | 2026-09-01 | 2026-09-09 |
| Retrospective Observational Study of Oral Complications and Quality of Life in Head and Neck Cancer Patients Treated With Radiotherapy or Chemoradiotherapy. Oral Mucositis, Quality of Life | Not yet recruiting | Mucosa Innovations, S.L. | 60 | 2026-08-01 | 2026-07-31 | |
| Mobile Dual-Task Brain and Balance Intervention for Concussion Recovery Home-Based Mobile Dual-Task Intervention (BraW-Day™) - Mild Traumatic Brain Injury (mTBI), Sports-related Concussion | Not applicable | Not yet recruiting | Hyunhwa Lee | 20 | 2026-05-15 | 2026-05-20 |
| AI-Assisted Saliva Diagnostics Using an Electrochemical Sensor Platform for Periodontitis Detection (SALIENCE) Periodontal Diseases, Biomarkers (D23.050.301) | Not yet recruiting | Ostergotland County Council, Sweden | 200 | 2025-12-01 | 2025-11-28 | |
| Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening DNA-methylation in saliva - Epigenetics, DNA Methylation | Not applicable | Recruiting | University Hospital, Antwerp | 1000 | 2025-10-04 | 2026-06-08 |
| Discovery and Validation of Periodontitis Biomarkers Diagnostic procedures - Periodontitis, Biomarker in Early Diagnosis | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 228 | 2025-07-21 | 2026-04-20 | |
| Application of Salivary Biomarkers in Risk Assessment for Oral Diseases in Children With Type 1 Diabetes Taking saliva samples of unstimulated saliva will be collected in sterile containers, salivets., Dental status, Periodontal status - Biomarkers, Saliva | Active not recruiting | University of Novi Sad | 112 | 2025-01-31 | 2025-04-11 | |
| Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics Saliva, Oral Lichen Planus | Completed | Kocaeli University | 21 | 2024-12-25 | 2026-02-18 | |
| Influence of Timing of Implant Placement on Early Healing Molecular Events Immediate implant placement and guided bone regeneration (Test), Late implant placement and guided bone regeneration (Control) - Dental Implant, Healing Wound | Not applicable | Recruiting | Queen Mary University of London | 24 | 2024-09-26 | 2026-09-01 |
| Interleukin-2 (IL-2), Interleukin-5 (IL-5) and Interleukin-17 (IL-17) Levels of Patients With Stainless Steel Crowns Salivary Collection, Ph and ion level measurement of saliva - Saliva, Dental Crown | Completed | Yuzuncu Yil University | 12 | 2024-09-10 | 2025-06-18 | |
| Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels Sliva Procalcitonin - Bacterial Infections, Children, Only | Not applicable | Unknown | Ege University | 160 | 2024-06-01 | 2024-04-09 |
| Effect of Implant Surface Material and Topography on Bone Regeneration. Zirconia surface implant and guided bone regeneration, Hydrophilic titanium surface implant and guided bone regeneration - Dental Implant, Guided Bone Regeneration | Not applicable | Completed | Queen Mary University of London | 12 | 2024-05-01 | 2026-07-17 |
| Dual-Task Exercise for Mild Traumatic Brain Injury (mTBI) Brain & Walk Exercise Every Day (BraW-Day) - TBI (Traumatic Brain Injury), Brain Concussion | Not applicable | Completed | University of Nevada, Las Vegas | 19 | 2024-03-06 | 2025-06-05 |
| GCF and Saliva Levels of IL-36α in Periodontal Disease Collection of fluid samples - Periodontal Diseases, Saliva | Not applicable | Completed | Ordu University | 80 | 2023-12-10 | 2026-03-27 |
| PREDICTIVE ABILITY OF A PANEL OF BIOMARKERS IN SALIVA IN HEALTHY AND PERIODONTALLY AFFECTED SUBJECTS Salivaru biomarkers - Periodontitis, Saliva | Completed | Universidad Complutense de Madrid | 100 | 2023-10-23 | 2025-06-26 | |
| Comparison of Saliva Biomarkers in Two Different Geographical Regions of Turkey Non-Surgical Intervention, Saliva Collection (Baseline), Probing - Saliva, Cortisol | Not applicable | Completed | Karabuk University | 77 | 2023-01-02 | 2025-02-05 |
| Effect of 5% Aqueous Propolis in Salivary and Dental Plaque pH in Children Effect of aqueous propolis gums in salivary and dental plaque pH in children, Effect of placebo gums in salivary and dental plaque pH in children - Child, Saliva | Not applicable | Completed | Damascus University | 30 | 2022-12-16 | 2023-09-29 |
| Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs. XCM-OM118 Composition comprising olive oil, betaine and xylitol - Oral Mucositis, Quality of Life | Not applicable | Recruiting | Mucosa Innovations, S.L. | 63 | 2022-10-11 | 2026-04-15 |
| Antibacterial Effect and Substantivity of a New Chlorhexidine and Cymenol Gel on Oral Biofilm and Saliva 0.20% CHX gel on saliva, 0.20% CHX and Cymenol gel on saliva, 0.20% CHX gel on oral biofilm - Healthy, Saliva | Phase 1 | Completed | University of Santiago de Compostela | 30 | 2022-09-01 | 2024-07-29 |
| Epigenetic Biomarkers in the Saliva for the Diagnosis of Squamous Cells Carcinoma of the Oral Cavity saliva tube - Oral Squamous Cell Carcinoma, Maxillo-facial Surgery | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 60 | 2022-03-03 | 2026-05-13 |
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Periodontitis (4) · Periodontal Diseases (3) · Brain Concussion (2) · COVID-19 (2) · Dental Plaque (2) · Mucositis (2) · Pain (2) · Radiation Injuries (2) · Speech (2) · Stomatitis (2) · Ulcer (2) · Alveolar Bone Loss (1) · Bacterial Infections (1) · Brain Injuries, Traumatic (1) · Coronavirus Infections (1)
Stomatognathic Diseases (13) · Mouth Diseases (10) · Behavior (5) · Pathological Conditions, Signs and Symptoms (4) · Wounds and Injuries (4) · Neoplasms (3) · Neoplasms by Site (3) · Pathologic Processes (3) · Periodontal Diseases (3) · Brain Diseases (2) · Brain Injuries (2) · Central Nervous System Diseases (2) · Communication (2) · Coronaviridae Infections (2) · Craniocerebral Trauma (2)
Betaine (1) · Cetylpyridinium (1) · DNA Methylation (1) · Diagnostic Techniques and Procedures (1) · Etoricoxib (1) · Hydrogen Peroxide (1) · Hydrogen-Ion Concentration (1) · Mouthwashes (1) · Natural Childbirth (1) · Orthodontic Appliances, Fixed (1) · Povidone-Iodine (1) · Sodium Hypochlorite (1) · Water (1) · Xylitol (1) · hydrated silica gel-based toothpaste (1)
Mucosa Innovations, S.L. (2) · Queen Mary University of London (2) · Centre Hospitalier Universitaire, Amiens (1) · Claude Bernard University (1) · Damascus University (1) · Ege University (1) · Gadjah Mada University (1) · Hospital Infantil de Mexico Federico Gomez (1) · Hyunhwa Lee (1) · Karabuk University (1) · King Abdulaziz University (1) · Kocaeli University (1) · LI-JU Chen (1) · Meir Medical Center (1) · Ordu University (1)
Turkey (Türkiye) (5) · Spain (4) · France (2) · Saudi Arabia (2) · United Kingdom (2) · United States (2) · Belgium (1) · China (1) · India (1) · Indonesia (1) · Israel (1) · Italy (1) · Mexico (1) · Serbia (1) · Syria (1)
Nikolaos Donos (2) · Annemiek Snoeckx, MD, PhD (1) · Dr.Sumit S. Shetgar, BDS (1) · Florence Carrouel, Dr (1) · Iman J Alahmad, DDs (1) · Juni Handajani, PhD (1) · Luca Levrini, Prfo. MD. (1) · Shadi Azzawi, Phd (1)
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