13 completed, 5 not yet recruiting, 4 active not recruiting, 4 unknown. 22 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 7, Not yet recruiting 5, Active not recruiting 4, Unknown 4, Enrolling by invitation 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Root Canal Treatment: new trials by email Literature Review of Root Canal Treatment trials Research Report on Root Canal Treatment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment Intracanal cryotherapy, Standard room-temperature irrigation - Postoperative Pain After Endodontic Treatment, Dental Anxiety | Not applicable | Not yet recruiting | Alanya Alaaddin Keykubat University | 130 | 2026-11-01 | 2026-10-28 |
| This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. Endo-ice (Refrigerant Spray), Ice-sticks - Root Canal Treatment, Intra-operative Pain | Not applicable | Not yet recruiting | Dow University of Health Sciences | 90 | 2026-09-15 | 2026-08-25 |
| Clinical Performance of AH Plus Jet® Root Canal Sealers in Single-cone Protocols AH Plus Jet® Endodontic Sealer, AH Plus Jet® Root Canal Sealing Material - Root Canal Treatment | Not applicable | Recruiting | Dentsply Sirona Implants and Consumables | 130 | 2026-09-09 | 2026-09-11 |
| Diagnostic Accuracy of a Deep Learning Framework for Automated Evaluation of Root Canal Obturation Quality From Periapical Radiographs Deep learning model - Root Canal Treatment, Obturation Quality | Not applicable | Not yet recruiting | Cairo University | 490 | 2026-08-01 | 2026-07-06 |
| Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers root canal treatment - Root Canal Treatment, Irreversible Acute Pulpitis | Not applicable | Not yet recruiting | Cairo University | 30 | 2026-05-01 | 2026-05-08 |
| Treatment Outcome and Patient-reported Outcomes in Patient Undergoing Non-surgical Root Canal Treatment With Different Irrigation Protocols root canal treatment and intracanal medicament - Root Canal Treatment, Irrigation Activation | Not applicable | Active not recruiting | Chulalongkorn University | 90 | 2025-11-07 | 2026-03-05 |
| Histological Evaluation in the Efficacy of GentleWave in Root Canal Pulp Tissue Debridement and Disinfection of Difficult to Reach Areas in Mandibular Human Molars II. An In-vivo Study. GentleWave - Root Canal Treatment | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 50 | 2025-11-01 | 2025-09-12 |
| Evaluation of the Effects of Different Irrigation Solutions and Activation Methods on Postoperative Pain and Quality of Life in Root Canal Treatment Irrigation with Sodium Hypochlorite and Conventional Syringe, Irrigation with Sodium Hypochlorite and EDDY, Procedure: Irrigation with Sodium Hypochlorite and Diode Laser - Irreversible Acute Pulpitis, Root Canal Treatment | Not applicable | Active not recruiting | Ankara Yildirim Beyazıt University | 90 | 2025-11-01 | 2025-11-21 |
| Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management Ibuprofen, Diclofenac sodium - Irreversible Pulpitis, Post-endodontic Pain | Phase 4 | Completed | Armed Forces Institute of Dentistry, Pakistan | 60 | 2025-10-01 | 2026-05-04 |
| Effect of Probiotics, Double Antibiotic Paste, and Calcium Hydroxide on Postoperative Pain in Irreversible Pulpitis: A Randomized Trial Probiotic - Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis | Not applicable | Completed | Dow University of Health Sciences | 75 | 2025-06-01 | 2025-12-08 |
| On Previously Root Canal-treated Patients Using an AI Program, Detect the Accuracy of it in the Detection of Root Canal Obturation Quality on CBCT Compared With Conventional PA Radiography, e.g., Voids, Length of Obturation, and Density, and Then do Retreatment if Any Failure is Recorded. root canal retreatment - Root Canal Treatment | Not applicable | Enrolling by invitation | Tala Ghassan Hassan Odeh | 3 | 2025-04-01 | 2025-07-09 |
| The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments Bio-C Temp Intracanal Medication, Metapaste Intracanal Medication - Root Canal Treatment, Intracanal Medicament | Not applicable | Active not recruiting | Ege University | 80 | 2024-08-01 | 2025-10-07 |
| Retrospective Database Study: Influence of Post-endodontic Restoration Placement on Survival of Root Canal-treated Teeth No patient treatment is associated with the study - Root Canal Treatment | Completed | University of Göttingen | 541 | 2024-06-01 | 2026-01-27 | |
| Different Kinematics Within a Single-File System and Postoperative Pain Twisted Adaptive motion (TFA), canal pro jeni, forward reciprocation - Root Canal Treatment, Postoperative Pain | Not applicable | Active not recruiting | Jordan University of Science and Technology | 75 | 2024-04-10 | 2026-07-13 |
| Effect of Endodontic Case Difficulty on Endodontic Mishaps: Clinical Study Case Group - Effect of Endodontic Case Difficulty on Endodontic Mishaps, Root Canal Treatment | Completed | Kutahya Health Sciences University | 200 | 2024-01-01 | 2024-10-15 | |
| Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up AH-Plus Epoxy Resin Sealer, bioceramic sealer - Root Canal Treatment | Not applicable | Completed | Medipol University | 120 | 2024-01-01 | 2025-11-24 |
| Post-Endodontic Pain According to Menstrual Cycle Phases root canal treathment - Root Canal Treatment | Completed | Ahter Sanal Cikman | 99 | 2023-09-01 | 2025-12-26 | |
| Traditional Versus Conservative Access Cavities Cleaning Ability Conservative Access Opening, Traditional Access Opening - Root Canal Infection, Root Canal Treatment | Not applicable | Unknown | University of Baghdad | 82 | 2022-09-12 | 2023-09-13 |
| Simultaneous Working Length Detection Methods EWL, SWL, RWL - Irreversible Pulpitis, Root Canal Treatment | Not applicable | Completed | Istanbul Medipol University Hospital | 100 | 2022-06-01 | 2024-07-18 |
| A First in Human Study to Compare Feasibility of Inertial Cavitation Irrigation to SNI in Root Canal Treatment. Conventional irrigation, Inertial cavitation - Root Canal Treatment, Post Operative Pain | Not applicable | Completed | Lumendo AG | 10 | 2022-05-10 | 2024-07-25 |
Showing 20 of 28. Sign in to see all of them.
Pain, Postoperative (10) · Dental Pulp Diseases (2) · Periapical Periodontitis (2) · Bites and Stings (1) · Dental Caries (1) · Dental Pulp Necrosis (1) · Mandibular Nerve Injuries (1) · Paresthesia (1) · Toothache (1)
Pathological Conditions, Signs and Symptoms (12) · Neurologic Manifestations (11) · Pathologic Processes (11) · Signs and Symptoms (11) · Pain (10) · Postoperative Complications (10) · Stomatognathic Diseases (8) · Tooth Diseases (5) · Mouth Diseases (3) · Jaw Diseases (2) · Periapical Diseases (2) · Periodontal Diseases (2) · Periodontitis (2) · Wounds and Injuries (2) · Chemically-Induced Disorders (1)
Calcium Hydroxide (1) · Diagnosis-Related Groups (1) · Diclofenac (1) · Etidronic Acid (1) · Ibuprofen (1) · Lasers, Semiconductor (1) · Metapex (1) · Methods (1) · Probiotics (1) · Root Canal Obturation (1) · Root Canal Preparation (1) · Sodium Hypochlorite (1) · Therapeutic Irrigation (1) · tricalcium silicate (1)
Cairo University (2) · Dow University of Health Sciences (2) · Mansoura University (2) · Ahter Sanal Cikman (1) · Ain Shams University (1) · Alanya Alaaddin Keykubat University (1) · Altamash Institute of Dental Medicine (1) · Ankara Yildirim Beyazıt University (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Barzilai Medical Center (1) · Chulalongkorn University (1) · Dentsply Sirona Implants and Consumables (1) · Ege University (1) · Istanbul Medipol University Hospital (1) · Jordan University of Science and Technology (1)
Turkey (Türkiye) (8) · Egypt (4) · Pakistan (4) · United States (2) · Germany (1) · Iraq (1) · Israel (1) · Jordan (1) · Thailand (1) · United Kingdom (1)
Salwa M Awad, Prof (2) · Abdel Moneim A. Elkalashy, Assis.lecturer (1) · Ahmed H Ali, Ph.D (1) · Aladdin Al Qudah, BDS, MSc, PhD (1) · David E Jaramillo, DDS (1) · Emine Guzel, PhD (1) · Farah Naz, BDS, FCPS (1) · Fathi A Qasem, PhD (1) · Francesco Mannocci, PhD (1) · Furkan S Bilgi, PhD (1) · Hatice Buyukozer Ozkan, PhD (1) · Lina Elsalem Elsalem, BDS, MSc, PhD (1)