15 completed, 3 terminated, 3 unknown, 2 active not recruiting. 24 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 24 | Completed 15, Terminated 3, Unknown 3, Active not recruiting 2, Enrolling by invitation 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
Follow Retinoblastoma: new trials by email Literature Review of Retinoblastoma trials Research Report on Retinoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma GPC2 CAR T cells - Refractory Neuroblastoma, Relapsed Neuroblastoma | Phase 1 | Enrolling by invitation | Stephan Grupp MD PhD | 45 | 2023-05-23 | 2026-08-14 |
| Topotecan Episcleral Plaque for Treatment of Retinoblastoma Episcleral Topotecan - Retinoblastoma | Phase 1 | Unknown | Targeted Therapy Technologies, LLC | 42 | 2021-06-16 | 2023-10-31 |
| Intra-arterial Chemotherapy for Retinoblastoma Melphalan - Retinoblastoma | Phase 1 | Completed | Washington University School of Medicine | 5 | 2020-08-11 | 2025-05-11 |
| B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ B7H3-EGFRt-DHFR, second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG, Pembrolizumab - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 68 | 2020-07-13 | 2026-04-28 |
| Topotecan Episcleral Plaque for Treatment of Retinoblastoma Topotecan Episcleral Plaque - Retinoblastoma | Phase 1 | Completed | The Hospital for Sick Children | 26 | 2020-06-16 | 2024-12-13 |
| EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ EGFR806-EGFRt, second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 44 | 2019-06-18 | 2026-10-08 |
| Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Carboplatin, Maxitrol®, Focal Therapy - Retinoblastoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 8 | 2016-11-01 | 2020-02-20 |
| Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Simvastatin, Cyclophosphamide, Topotecan - Retinoblastoma, Clear Cell Sarcoma | Phase 1 | Completed | Emory University | 13 | 2015-02-01 | 2020-04-03 |
| Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocular Retinoblastoma Melphalan, Carboplatin, Etoposide - Advanced Intra-Ocular Retinoblastoma, Retinoblastoma | Phase 1 | Terminated | University of California, San Francisco | 6 | 2014-07-23 | 2020-04-16 |
| Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors Metronomic Cyclophosphamide, Thalidomide - Glioma, Neuroectodermal Tumors, Primitive | Phase 1 | Completed | Washington University School of Medicine | 14 | 2012-10-26 | 2024-01-31 |
| Intra-arterial Chemotherapy for Children With Retinoblastoma Intra-arterial injection of melphalan, Injection of melphalan into the ophthalmic artery - Retinoblastoma | Phase 1 / Phase 2 | Unknown | Hadassah Medical Organization | 10 | 2011-06-01 | 2016-10-04 |
| Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors sirolimus - Ewing's Sarcoma, Osteosarcoma | Phase 1 | Completed | Emory University | 18 | 2011-04-01 | 2020-05-29 |
| Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides racotumomab - Neuroblastoma, Ewing's Sarcoma | Phase 1 | Completed | Laboratorio Elea Phoenix S.A. | 15 | 2011-02-01 | 2015-07-29 |
| Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features Seneca Valley virus-001, cyclophosphamide, laboratory biomarker analysis - Adrenocortical Carcinoma, Gastrointestinal Carcinoid Tumor | Phase 1 | Completed | Children's Oncology Group | 22 | 2009-09-01 | 2014-01-30 |
| Phase I Trial of Periocular Topotecan in Retinoblastoma Topotecan - Retinoblastoma | Phase 1 | Completed | Hospital JP Garrahan | 5 | 2007-03-01 | 2008-05-02 |
| Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma Intra-arterial Chemotherapy - Retinoblastoma | Phase 1 / Phase 2 | Completed | Weill Medical College of Cornell University | 100 | 2006-05-01 | 2009-12-17 |
| Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features Seneca Valley Virus (biological agent) - Carcinoid, Neuroendocrine | Phase 1 | Unknown | Neotropix | 60 | 2006-04-01 | 2010-02-25 |
| MT2004-30: Tomotherapy for Solid Tumors filgrastim, busulfan, etoposide - Brain and Central Nervous System Tumors, Kidney Cancer | Phase 1 | Terminated | Masonic Cancer Center, University of Minnesota | 23 | 2005-08-01 | 2017-12-05 |
| Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer filgrastim, carboplatin, etoposide - Brain and Central Nervous System Tumors, Lymphoma | Phase 1 | Completed | Roswell Park Cancer Institute | 1 | 2002-03-01 | 2011-03-01 |
| Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas alvocidib, pharmacological study - Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2001-04-01 | 2013-07-02 |
Showing 20 of 24. Sign in to see all of them.
Neuroblastoma (13) · Wilms Tumor (12) · Medulloblastoma (10) · Astrocytoma (8) · Osteosarcoma (8) · Sarcoma (8) · Sarcoma, Ewing (8) · Rhabdomyosarcoma (7) · Hepatoblastoma (6) · Optic Nerve Glioma (6) · Rhabdoid Tumor (6) · Central Nervous System Neoplasms (5) · Familial ependymoma (5) · Glioma (5)
Neoplasms by Histologic Type (24) · Neoplasms by Site (24) · Neoplasms, Glandular and Epithelial (24) · Neoplasms, Nerve Tissue (24) · Neoplasms, Neuroepithelial (24) · Eye Diseases (23) · Eye Diseases, Hereditary (23) · Eye Neoplasms (23) · Neuroectodermal Tumors (23) · Retinal Diseases (23) · Retinal Neoplasms (23) · Neoplasms (22) · Neoplasms, Germ Cell and Embryonal (20) · Neoplasms, Connective and Soft Tissue (14) · Neuroectodermal Tumors, Primitive (14)
Carboplatin (4) · Etoposide (4) · Filgrastim (4) · Granulocyte Colony-Stimulating Factor (4) · Melphalan (4) · Busulfan (3) · Cyclophosphamide (3) · Ifosfamide (2) · Peripheral Blood Stem Cell Transplantation (2) · Thiotepa (2) · Topotecan (2) · Amifostine (1) · Anti-Infective Agents (1) · Biological Factors (1) · Bone Marrow Transplantation (1)
Children's Oncology Group (2) · Emory University (2) · Masonic Cancer Center, University of Minnesota (2) · Seattle Children's Hospital (2) · Washington University School of Medicine (2) · Hadassah Medical Organization (1) · Hospital JP Garrahan (1) · Laboratorio Elea Phoenix S.A. (1) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1) · Neotropix (1) · Pediatric Brain Tumor Consortium (1) · Roswell Park Cancer Institute (1) · St. Jude Children's Research Hospital (1) · Stephan Grupp MD PhD (1)
United States (20) · Argentina (2) · Australia (1) · Canada (1) · Israel (1)
Andrew Cluster, M.D. (1) · Anuradha Banerjee, MD (1) · Barbara Jean Bambach, MD (1) · Brenda Gallie (1) · Catherine Albert, MD (1) · David H Abramson, MD (1) · Guillermo Chantada, MD (1) · Guillermo L Chantada, MD (1) · James Whitlock (1) · John P. Perentesis, MD (1) · Katie Albert, MD (1) · Kelly Goldsmith, MD (1) · Kim Kramer, MD (1) · Lisa Wray, MD (1) · Margaret Reynolds, M.D. (1)
PMID 31401903, PMID 15814645, PMID 16533779, PMID 18048828, PMID 18342944, PMID 18391430, PMID 18978345, PMID 26154941, PMID 31876107, PMID 39095033, PMID 39255444, PMID 41026583
R37CA282041 (1), U01CA097452 (1)