47 completed, 22 active not recruiting, 20 recruiting, 14 terminated. 60 Phase 1, 38 Phase 2, 5 Not applicable, 3 Early Phase 1, 3 Phase 3.
Follow Rhabdoid Tumor: new trials by email Literature Review of Rhabdoid Tumor trials Research Report on Rhabdoid Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT) 21.15.GPC3-CAR T Cells - Atypical Teratoid Rhabdoid Tumor, Central Nervous System Rhabdoid Tumor | Phase 1 | Not yet recruiting | Baylor College of Medicine | 21 | 2026-09-01 | 2026-04-07 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Study of Novel Therapies for Young People With Recurrent/Progressive Atypical Teratoid Rhabdoid Tumor (ATRT) Lumber Puncture, Blood Specimen Collection, Magnetic resonance imaging (MRI) - Recurrent Atypical Teratoid/Rhabdoid Tumor, Atypical Teratoid/Rhabdoid Tumor (ATRT) of the CNS | Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 29 | 2026-06-17 | 2026-06-23 |
| Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors Becotatug Vedotin - Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Nasopharyngeal Carcinoma | Phase 1 | Recruiting | Sun Yat-sen University | 51 | 2026-05-30 | 2026-05-13 |
| Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor Gallium maltolate - High Grade Gliomas, Atypical Teratoid Rhabdoid Tumors (ATRT) | Phase 1 | Not yet recruiting | Sarah Rumler | 15 | 2026-05-15 | 2026-01-09 |
| Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas Eflornithine (DFMO), AMXT 1501 Dicaprate - Atypical Teratoid/Rhabdoid Tumor, Embryonal Tumor With Multilayered Rosettes | Phase 1 / Phase 2 | Recruiting | Milton S. Hershey Medical Center | 265 | 2026-05-13 | 2026-09-03 |
| Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors Vertebral Body-Sparing Craniospinal Proton Irradiation - Pediatric Central Nervous System Tumors, Medulloblastoma | Not yet recruiting | Ruijin Hospital | 38 | 2026-04-30 | 2026-05-15 | |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
| GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults GPC2-CAR T cells, Fludarabine, Cyclophosphamide - Medulloblastoma, Central Nervous System Embryonal Tumor | Phase 1 | Recruiting | Stanford University | 18 | 2025-08-28 | 2026-10-09 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| Study to ONO-4538 in Patients With Rhabdoid Tumor ONO-4538 - Rhabdoid Tumor | Phase 2 | Recruiting | Ono Pharmaceutical Co., Ltd. | 23 | 2024-11-25 | 2026-08-04 |
| Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA), Group A Standard-of-Care Backbone Therapy, Group B Salvage Backbone Therapy - Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS | Phase 1 | Recruiting | Children's National Research Institute | 12 | 2024-09-20 | 2026-10-13 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors Idasanutlin, Selinexor - Rhabdoid Tumor, Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Withdrawn | St. Jude Children's Research Hospital | 2024-03-01 | 2024-03-27 | |
| Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors Tazemetostat, Nivolumab, Ipilimumab - Atypical Teratoid Rhabdoid Tumor, INI1 (SMARCB1)-Deficient Primary CNS Malignant Tumors | Phase 1 / Phase 2 | Active not recruiting | Susan Chi, MD | 49 | 2023-08-10 | 2026-04-13 |
| A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors Selinexor - Wilms Tumor, Rhabdoid Tumor | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 45 | 2023-08-01 | 2026-05-06 |
| Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors Anaplastic Astrocytoma, Diffuse Brainstem Glioma | Terminated | Pediatric Brain Tumor Consortium | 57 | 2023-07-12 | 2026-04-23 |
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Medulloblastoma (64) · Central Nervous System Neoplasms (45) · Neuroblastoma (43) · Sarcoma (41) · Rhabdomyosarcoma (40) · Wilms Tumor (38) · Ependymoma (36) · Osteosarcoma (35) · Glioma (33) · Sarcoma, Ewing (29) · Astrocytoma (28) · Brain Neoplasms (26) · Hepatoblastoma (26) · Familial ependymoma (25)
Neoplasms, Complex and Mixed (115) · Neoplasms by Histologic Type (114) · Neoplasms (107) · Neoplasms by Site (97) · Neoplasms, Glandular and Epithelial (88) · Neoplasms, Nerve Tissue (84) · Neuroectodermal Tumors (83) · Neoplasms, Neuroepithelial (80) · Nervous System Diseases (77) · Nervous System Neoplasms (77) · Neoplasms, Germ Cell and Embryonal (74) · Neuroectodermal Tumors, Primitive (60) · Neoplasms, Connective and Soft Tissue (56) · Central Nervous System Diseases (54) · Brain Diseases (53)
Cyclophosphamide (16) · Etoposide (14) · Carboplatin (11) · Temozolomide (10) · Filgrastim (9) · Granulocyte Colony-Stimulating Factor (9) · Vincristine (9) · Cisplatin (8) · Magnetic Resonance Spectroscopy (8) · Methotrexate (7) · Phantoms, Imaging (7) · Thiotepa (7) · X-Rays (7) · etoposide phosphate (7) · Radiotherapy (6)
National Cancer Institute (NCI) (21) · St. Jude Children's Research Hospital (10) · Pediatric Brain Tumor Consortium (9) · Children's Oncology Group (8) · Baylor College of Medicine (6) · Seattle Children's Hospital (6) · Emory University (4) · Dana-Farber Cancer Institute (3) · Epizyme, Inc. (3) · M.D. Anderson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (3) · Children's National Research Institute (2) · Masonic Cancer Center, University of Minnesota (2) · Sabine Mueller, MD, PhD (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1)
United States (103) · Canada (19) · Australia (15) · Puerto Rico (15) · Spain (4) · France (3) · Germany (3) · Italy (3) · New Zealand (3) · Switzerland (3) · United Kingdom (3) · Japan (2) · Belgium (1) · Brazil (1) · China (1)
Amar Gajjar, MD (5) · David Steffin, MD (4) · David Sandberg, MD (2) · Jasia Mahdi, MD (2) · Kim Kramer, MD (2) · Mark W. Kieran, MD, PhD (2) · Maryam Fouladi, MD (2) · Rebecca Ronsley, MD (2) · Thomas Cash, MD (2) · AeRang Kim (1) · Alexandra Miller, MD, PhD (1) · Alice Lee (1) · Allen R. Chen, MD, PhD, MHS (1) · Alyssa T Reddy (1) · Andrea T Franson (1)
PMID 31401903, PMID 33502920, PMID 11807556, PMID 17019740, PMID 17634493, PMID 18447671, PMID 19064966, PMID 20049936, PMID 20460632, PMID 23554030, PMID 24969367, PMID 25665007, PMID 25980737, PMID 26842751, PMID 29778738, PMID 31876107, PMID 32730180, PMID 33047248, PMID 33305087, PMID 33405951, PMID 33591402, PMID 33743477, PMID 33838625, PMID 33945291, PMID 34253928, PMID 34486544, PMID 34714708, PMID 35353553, PMID 35468680, PMID 36371226, PMID 37640679, PMID 38347552, PMID 38501690, PMID 38771986, PMID 38815151, PMID 38873934, PMID 38935895, PMID 39101481, PMID 39255444, PMID 39298716, PMID 39515374, PMID 39660994, PMID 39775044, PMID 40052556, PMID 41166674, PMID 41798119, PMID 42686334, PMID 42745490, PMID 42853672, PMID 42867148
U10CA180886 (14), U01CA081457 (5), U10CA098543 (3), UM1CA081457 (3), U01CA097452 (2), 2015 (1), 2019 (1), 2023 (1), P30CA006516 (1), P30CA015083 (1), P30CA033572 (1), R01CA154619 (1), UG1CA189958 (1), UM1CA228823 (1)