59 completed, 11 terminated, 4 unknown, 4 withdrawn. 48 Phase 1, 21 Phase 2, 4 Not applicable, 3 Phase 3, 2 Early Phase 1.
Follow Optic Nerve Glioma: new trials by email Literature Review of Optic Nerve Glioma trials Research Report on Optic Nerve Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modified CV Regimen in Optic Pathway Glioma Carboplatin, Vincristine, Recombinant human endostatin - Optic Glioma, Pediatric Brain Tumor, Optic Nerve Glioma | Phase 2 | Recruiting | Beijing Sanbo Brain Hospital | 75 | 2022-04-13 | 2024-10-15 |
| Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours Selumetinib - Neurofibromatosis Type 1, Plexiform Neurofibroma | Phase 1 / Phase 2 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 14 | 2019-09-26 | 2024-04-04 |
| Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology ProTRAIT - Astrocytoma, Ependymoma | Recruiting | Maastricht Radiation Oncology | 1500 | 2018-01-01 | 2026-10-13 | |
| Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma Laboratory Biomarker Analysis, Selumetinib Sulfate - Cutaneous Neurofibroma, Neurofibromatosis Type 1 | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2017-08-26 | 2023-12-06 |
| Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas Radiation therapy, Temozolomide, Stem cell collection - Astrocytoma, Brainstem Glioma | Early Phase 1 | Withdrawn | Washington University School of Medicine | 2017-01-01 | 2017-02-20 | |
| Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors MRI-guided laser ablation, Doxorubicin, Etoposide - Glioma, Pilocytic Astrocytoma | Phase 2 | Terminated | Washington University School of Medicine | 6 | 2015-08-14 | 2024-11-01 |
| Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Laboratory Biomarker Analysis, Pharmacological Study, Pomalidomide - Neurofibromatosis Type 1, Recurrent Childhood Brain Stem Glioma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2015-07-14 | 2022-04-25 |
| Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Photofrin photodynamic therapy. - Brain Tumor, Recurrent | Phase 2 | Terminated | Harry T Whelan, MD | 1 | 2015-06-01 | 2019-08-20 |
| 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas 18F-fluoro-dihydroxyphenylalanine, Positron emission tomography (PET), Computed tomography (CT) - Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma | Not applicable | Terminated | Erik Mittra | 2 | 2014-12-01 | 2017-03-20 |
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Mebendazole, Vincristine, Carboplatin - Pilomyxoid Astrocytoma, Pilocytic Astrocytoma | Phase 1 / Phase 2 | Active not recruiting | Julie Krystal | 10 | 2013-10-22 | 2026-08-06 |
| Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors gallium Ga 68-edotreotide, positron emission tomography, computed tomography - Acoustic Schwannoma, Adult Anaplastic Astrocytoma | Not applicable | Withdrawn | Sue O'Dorisio | 2013-09-01 | 2017-04-28 | |
| Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors Photofrin (porfimer sodium) & photodynamic therapy. - Brain Tumor, Recurrent | Phase 1 | Completed | Harry T Whelan, MD | 5 | 2013-03-01 | 2019-02-25 |
| PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1) Neurofibromatosis-1, Optic Glioma | Completed | UNC Lineberger Comprehensive Cancer Center | 30 | 2013-01-16 | 2021-05-12 | |
| Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Lenalidomide, Pharmacological Study - Neurofibromatosis Type 1, Recurrent Childhood Pilocytic Astrocytoma | Phase 2 | Completed | National Cancer Institute (NCI) | 75 | 2012-07-05 | 2025-01-07 |
| Phase 3 Study of ANP Therapy vs. TMZ for Optic Pathway Glioma Temozolomide, ANP Therapy - Optic Nerve Glioma | Phase 3 | Withdrawn | Burzynski Research Institute | 2011-12-01 | 2017-07-26 | |
| Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma imetelstat sodium, laboratory biomarker analysis, pharmacological study - Brain and Central Nervous System Tumors, Lymphoma | Phase 1 | Completed | Children's Oncology Group | 34 | 2011-05-01 | 2014-01-30 |
| PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors VEGF inhibitor PTC299 - Brain and Central Nervous System Tumors | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 28 | 2010-11-01 | 2015-05-04 |
| Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer cyproheptadine hydrochloride, placebo - Cancer | Phase 3 | Terminated | University of South Florida | 22 | 2010-06-01 | 2015-07-02 |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
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Astrocytoma (74) · Medulloblastoma (56) · Oligodendroglioma (56) · Familial ependymoma (55) · Central Nervous System Neoplasms (46) · Choroid Plexus Neoplasms (42) · Neuroblastoma (22) · Neuroectodermal Tumors, Primitive, Peripheral (19) · Rhabdoid Tumor (18) · Sarcoma (18) · Brain Neoplasms (16) · Osteosarcoma (16) · Spinal Cord Neoplasms (16) · Dendritic Cell Sarcoma, Interdigitating (15)
Cranial Nerve Diseases (82) · Cranial Nerve Neoplasms (82) · Eye Diseases (82) · Neoplasms by Histologic Type (82) · Neoplasms by Site (82) · Neoplasms, Glandular and Epithelial (82) · Neoplasms, Nerve Tissue (82) · Nervous System Diseases (82) · Nervous System Neoplasms (82) · Neuroectodermal Tumors (82) · Optic Nerve Diseases (82) · Optic Nerve Neoplasms (82) · Peripheral Nervous System Neoplasms (82) · Neoplasms, Germ Cell and Embryonal (80) · Neoplasms (79)
Carboplatin (13) · Temozolomide (11) · Filgrastim (9) · Etoposide (6) · Radiotherapy (6) · Vincristine (5) · Granulocyte Colony-Stimulating Factor (4) · Irinotecan (4) · Busulfan (3) · Ifosfamide (3) · O(6)-benzylguanine (3) · Peripheral Blood Stem Cell Transplantation (3) · etoposide phosphate (3) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · Cilengitide (2)
National Cancer Institute (NCI) (25) · Children's Oncology Group (12) · Pediatric Brain Tumor Consortium (8) · Children's Cancer and Leukaemia Group (3) · Duke University (3) · National Institutes of Health Clinical Center (CC) (3) · City of Hope Medical Center (2) · Harry T Whelan, MD (2) · Memorial Sloan Kettering Cancer Center (2) · University of South Florida (2) · Washington University School of Medicine (2) · Beijing Sanbo Brain Hospital (1) · Burzynski Research Institute (1) · Daiichi Sankyo (1) · Erik Mittra (1)
United States (70) · Canada (18) · Australia (8) · Switzerland (7) · New Zealand (6) · Puerto Rico (6) · United Kingdom (5) · Netherlands (4) · Ireland (2) · Austria (1) · Belgium (1) · China (1) · Croatia (1) · Denmark (1) · France (1)
Elizabeth Fox, MD (3) · Henry S. Friedman, MD (3) · Harry T Whelan, MD (2) · Katherine Warren, MD (2) · Kim Kramer, MD (2) · Mark W. Kieran, MD, PhD (2) · Maryam Fouladi (2) · Regina Jakacki, MD (2) · Susan M. Blaney, MD (2) · Tobey MacDonald (2) · A Mendez Romero (1) · AeRang Kim, MD (1) · Allen R. Chen, MD, PhD, MHS (1) · Amar Gajjar (1) · Andrew Cluster, M.D. (1)
PMID 15814645, PMID 16234526, PMID 16408203, PMID 16533779, PMID 16914576, PMID 17610262, PMID 17634493, PMID 17941066, PMID 18048828, PMID 18281544, PMID 18281546, PMID 18989154, PMID 19065567, PMID 19075272, PMID 19430790, PMID 20044751, PMID 20049936, PMID 20381270, PMID 20460632, PMID 21115653, PMID 21764821, PMID 22665535, PMID 23554030, PMID 23857966, PMID 24321536, PMID 28649001, PMID 32152628, PMID 32580249, PMID 35007270, PMID 37126770, PMID 37260252, PMID 38907342, PMID 39418437, PMID 40009403, PMID 9849694
U01CA081457 (9), U01CA097452 (8), U10CA098543 (6), U10CA081920 (2), 2005 (1), P30CA012197 (1), P30CA013148 (1), P30CA033572 (1), P30CA086862 (1), P30CA124435 (1), U10CA180886 (1), UG1CA189958 (1), UM1CA081457 (1)