30 completed, 16 active not recruiting, 15 recruiting, 9 unknown. 33 Phase 2, 22 Phase 1, 10 Phase 3, 4 Not applicable, 1 Early Phase 1.
Follow Hepatoblastoma: new trials by email Literature Review of Hepatoblastoma trials Research Report on Hepatoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| Pucotenlimab Combined With Lenvatinib and Chemotherapy in the Treatment of Advanced, Relapsed/Refractory Hepatoblastoma in Children Pucotenlimab ,Lenvatinib - Hepatoblastoma, Pediatric Cancer | Not applicable | Recruiting | Sun Yat-sen University | 24 | 2025-04-10 | 2025-09-23 |
| A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer Cobolimab, Dostarlimab - Melanoma, Hodgkin Lymphoma | Phase 1 / Phase 2 | Active not recruiting | GlaxoSmithKline | 83 | 2025-03-06 | 2025-11-12 |
| Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models Neuroblastoma, Medulloblastoma | Completed | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 1229 | 2025-01-22 | 2026-08-04 | |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers Hepatocholangiocarcinoma, Fibrolamellar Carcinoma | Recruiting | Federation Francophone de Cancerologie Digestive | 150 | 2024-03-26 | 2025-08-05 | |
| Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy Sodium Thiosulfate - Ototoxicity, Drug-Induced | Early Phase 1 | Suspended | Children's Hospital Medical Center, Cincinnati | 33 | 2023-03-01 | 2026-10-22 |
| Evaluation of Lung Metastases Based on Ultrashort Echo Time MRI Hepatoblastoma, Radiology | Completed | RenJi Hospital | 65 | 2023-01-01 | 2024-04-18 | |
| GastroIntestinal Cancer in Children and Adolescents Gastrointestinal Cancer, Colorectal Cancer | Unknown | Paul G. Kemps, MD | 2500 | 2022-12-22 | 2023-01-23 | |
| Relapsed and Refractory Hepatoblastoma: A Prospective Registry and Liver Tumor Research Consortium Initiative Biospecimen collection - Relapsed Hepatoblastoma, Refractory Hepatoblastoma | Recruiting | Children's Hospital Medical Center, Cincinnati | 500 | 2022-09-07 | 2026-03-18 | |
| ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma ET140203 T Cells - Hepatoblastoma, Hepatocellular Carcinoma (HCC) | Phase 1 / Phase 2 | Recruiting | Eureka Therapeutics Inc. | 12 | 2022-07-19 | 2026-07-06 |
| B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) Fludarabine, Cyclophosphamide, MESNA - Pediatric Solid Tumor, Osteosarcoma | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 48 | 2022-07-06 | 2026-05-19 |
| Sequential PD-1/PD-L1 Inhibitor and LENvatinib in TLCT and Refractory Hepatoblastoma After Chemotherapy PD-1 inhibitor - Transitional Cell Tumor, Hepatoblastoma | Phase 2 / Phase 3 | Unknown | RenJi Hospital | 15 | 2022-04-10 | 2022-04-11 |
| Psychosocial Situation of Children With Rare Solid Abdominal Tumors and Their Families Neuroblastoma, Nephroblastoma | Completed | Universitätsklinikum Hamburg-Eppendorf | 100 | 2022-02-21 | 2024-06-11 | |
| Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors Cryoablation Therapy, Nivolumab, Ipilimumab - Osteosarcoma, Ewing Sarcoma | Phase 2 | Completed | Children's National Research Institute | 5 | 2022-02-18 | 2025-01-01 |
| Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint - Colorectal Carcinoma, Endometrial Carcinoma | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 147 | 2021-11-08 | 2026-08-25 |
| Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors VAL-413, Temozolomide - Solid Tumors, Neuroblastoma | Phase 1 | Active not recruiting | Valent Technologies, LLC | 20 | 2021-10-25 | 2026-07-30 |
| Diagnostic Efficacy and Prognostic Value of 18F-FDG PET/CT (MR) in Pediatric Solid Blastoma Telephone follow-up - 18F-FDG, Neuroblastoma | Completed | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 50 | 2021-07-30 | 2024-03-19 | |
| A Prospective Multicenter Clinical Study of SCCG Protocol and ctDNA 5hmc in Predicting the Chemotherapy Sensitivity and Monitoring the Recurrence and Metastasis of Hepatoblastoma in Children and Adolescents Very low-risk group, Low-risk group, Intermediate-risk group - Hepatoblastoma | Phase 2 | Recruiting | Sun Yat-sen University | 100 | 2021-06-23 | 2025-12-23 |
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Neuroblastoma (45) · Wilms Tumor (38) · Rhabdomyosarcoma (35) · Osteosarcoma (33) · Sarcoma (33) · Sarcoma, Ewing (28) · Medulloblastoma (27) · Rhabdoid Tumor (26) · Neuroectodermal Tumors, Primitive, Peripheral (21) · Central Nervous System Neoplasms (18) · Ependymoma (16) · Glioma (16) · Liver Neoplasms (16) · Carcinoma, Hepatocellular (14)
Neoplasms by Histologic Type (81) · Neoplasms, Complex and Mixed (81) · Neoplasms (71) · Neoplasms by Site (60) · Neoplasms, Glandular and Epithelial (59) · Neoplasms, Nerve Tissue (50) · Neoplasms, Connective and Soft Tissue (49) · Neuroectodermal Tumors (48) · Female Urogenital Diseases (47) · Female Urogenital Diseases and Pregnancy Complications (47) · Male Urogenital Diseases (47) · Neoplasms, Neuroepithelial (47) · Urogenital Diseases (47) · Neuroectodermal Tumors, Primitive (45) · Urogenital Neoplasms (45)
Carboplatin (8) · Cisplatin (8) · Phantoms, Imaging (7) · Specimen Handling (7) · X-Rays (7) · Cyclophosphamide (6) · Magnetic Resonance Spectroscopy (6) · Biopsy (5) · Doxorubicin (5) · Etoposide (5) · Granulocyte Colony-Stimulating Factor (5) · Nuclear Medicine Department, Hospital (5) · Vincristine (5) · sodium thiosulfate (5) · Fluorouracil (4)
National Cancer Institute (NCI) (16) · Children's Oncology Group (9) · Emory University (4) · Masonic Cancer Center, University of Minnesota (3) · Memorial Sloan Kettering Cancer Center (3) · Seattle Children's Hospital (3) · Baylor College of Medicine (2) · Children's Hospital Medical Center, Cincinnati (2) · RenJi Hospital (2) · Shanghai Children's Medical Center (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · St. Jude Children's Research Hospital (2) · Sun Yat-sen University (2) · University of Birmingham (2) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (2)
United States (53) · Puerto Rico (15) · China (10) · Canada (9) · Australia (8) · France (7) · United Kingdom (6) · Italy (4) · Netherlands (4) · Ireland (3) · Spain (3) · Czechia (2) · Germany (2) · Switzerland (2) · Austria (1)
Howard Katzenstein (2) · Katherine Somers, MD (2) · AeRang Kim (1) · AeRang Kim, MD, PhD (1) · Aerang Kim, M.D. (1) · Alice Lee (1) · Allen R. Chen, MD, PhD, MHS (1) · Alok Kothari, M.D. (1) · Andras Heczey, MD (1) · Andrea T Franson (1) · Anna Konstantinova, MD (1) · Ashish Gupta, MBBS, MPH (1) · Brad H. Pollock, PhD (1) · Brenda Weigel, MD (1)
PMID 31401903, PMID 23683550, PMID 23831416, PMID 27914822, PMID 29924955, PMID 19846851, PMID 22547603, PMID 27884679, PMID 30406959, PMID 30777875, PMID 31160205, PMID 31876107, PMID 33591402, PMID 34157616, PMID 34435684, PMID 34486544, PMID 35353553, PMID 37462798, PMID 37606641, PMID 38622445, PMID 38815151, PMID 38873934, PMID 38935895, PMID 39255444, PMID 39298716, PMID 41166674, PMID 42246993, PMID 42686334, PMID 42853672, PMID 42867148, PMID 9849694
U10CA180886 (15), U10CA098543 (5), P01CA225618 (1), P30CA008748 (1), U10CA081920 (1), UM1CA081457 (1), UM1CA228823 (1)