15 completed, 14 terminated, 4 withdrawn, 2 active not recruiting. 22 Phase 1, 11 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 12, Terminated 8, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 11 | Terminated 5, Active not recruiting 2, Completed 2, Withdrawn 2 |
| Not applicable | 1 | Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Biological G207 - Neoplasms, High Grade Glioma | Phase 2 | Withdrawn | Pediatric Brain Tumor Consortium | 2025-09-01 | 2026-02-10 | |
| Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors Anaplastic Astrocytoma, Diffuse Brainstem Glioma | Terminated | Pediatric Brain Tumor Consortium | 57 | 2023-07-12 | 2026-04-23 | |
| 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Irinotecan, Temozolomide, Bevacizumab - Recurrent Medulloblastoma, Recurrent Ependymoma | Phase 2 | Active not recruiting | Pediatric Brain Tumor Consortium | 62 | 2022-04-04 | 2026-07-28 |
| Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions to MediData/RAVE Medidata RAVE - Accurate and Complete Data Acquisition for Clinical Trials | Terminated | Children's Oncology Group | 46 | 2021-08-28 | 2026-09-14 | |
| INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas INCB7839 - Glioblastoma Multiforme, Anaplastic Astrocytoma | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 13 | 2020-07-27 | 2026-10-01 |
| A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration Dabrafenib, Trametinib, Hydroxychloroquine - Low Grade Glioma (LGG) of Brain With BRAF Aberration, High Grade Glioma (HGG) of the Brain With BRAF Aberration | Phase 1 / Phase 2 | Active not recruiting | Pediatric Brain Tumor Consortium | 57 | 2020-01-17 | 2026-09-11 |
| Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery CX 4945 - Medulloblastoma, Childhood, Medulloblastoma Recurrent | Phase 1 / Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 21 | 2019-07-25 | 2026-10-19 |
| A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemia Busulfan, Fludarabine, Cyclophosphamide - Fanconi Anemia, Myelodysplastic Syndrome (MDS) | Phase 2 | Terminated | Memorial Sloan Kettering Cancer Center | 3 | 2018-05-15 | 2022-04-12 |
| Phase I Study of APX005M in Pediatric Central Nervous System Tumors APX005M treatment for recurrent or refractory primary malignant CNS tumor patients, APX005M treatment for newly diagnosed DIPG patients - Glioblastoma Multiforme, High-grade Astrocytoma Not Otherwise Specified (NOS) | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 32 | 2018-03-01 | 2026-08-13 |
| Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors Everolimus, Laboratory Biomarker Analysis, Pharmacological Study - CNS Embryonal Tumor, Not Otherwise Specified, Malignant Glioma | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 22 | 2018-01-13 | 2021-08-27 |
| Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma LBH589 - Glioma | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 53 | 2016-06-28 | 2024-04-25 |
| Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors palbociclib isethionate, pharmacological study, laboratory biomarker analysis - Childhood Choroid Plexus Tumor, Childhood Ependymoblastoma | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 35 | 2014-12-08 | 2021-03-02 |
| Peginterferon Alfa-2b in Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery peginterferon alfa-2b, laboratory biomarker analysis - Childhood Craniopharyngioma | Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 19 | 2014-04-01 | 2020-02-24 |
| Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery oncolytic HSV-1716, dexamethasone, therapeutic conventional surgery - Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood Anaplastic Oligoastrocytoma | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 2 | 2013-12-01 | 2016-05-30 |
| p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors azurin-derived cell-penetrating peptide p28 - Teratoid Tumor, Atypical, Choroid Plexus Neoplasms | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 18 | 2013-08-01 | 2017-08-07 |
| Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors imetelstat sodium - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 43 | 2013-03-01 | 2018-07-20 |
| PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors VEGF inhibitor PTC299 - Brain and Central Nervous System Tumors | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 28 | 2010-11-01 | 2015-05-04 |
| Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy systemic chemotherapy, laboratory biomarker analysis, therapeutic surgical procedure - Brain and Central Nervous System Tumors | Not applicable | Withdrawn | Pediatric Brain Tumor Consortium | 2010-05-01 | 2019-04-01 | |
| MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer MK-0752 - Brain and Central Nervous System Tumors | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 33 | 2008-07-01 | 2012-03-06 |
| Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors enzastaurin hydrochloride - Brain and Central Nervous System Tumors, Neuroblastoma | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 32 | 2007-06-01 | 2012-03-06 |
Showing 20 of 35. Sign in to see all of them.
Astrocytoma (18) · Central Nervous System Neoplasms (17) · Medulloblastoma (16) · Oligodendroglioma (14) · Choroid Plexus Neoplasms (12) · Familial ependymoma (11) · Rhabdoid Tumor (9) · Glioblastoma (8) · Optic Nerve Glioma (8) · Glioma (5) · Ependymoma (4) · Spinal Cord Neoplasms (3) · Brain Neoplasms (2) · Brain Stem Neoplasms (2) · Dendritic Cell Sarcoma, Interdigitating (2)
Radiotherapy (3) · Busulfan (2) · Capecitabine (2) · Cyclophosphamide (2) · Dexamethasone (2) · Neoadjuvant Therapy (2) · 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid (1) · Antiemetics (1) · Antilymphocyte Serum (1) · Antipyretics (1) · Bevacizumab (1) · Calcium Dobesilate (1) · Carmustine (1) · Chemotherapy, Adjuvant (1) · Everolimus (1)
United States (34) · Canada (1)
Susan M. Blaney, MD (3) · Mark W. Kieran, MD, PhD (2) · Maryam Fouladi, MD (2) · Roger J. Packer, MD (2) · Sri Gururangan, MD (2) · Stewart Goldman (2) · Alexandra Miller, MD, PhD (1) · Anuradha Banerjee, MD (1) · Brian R. Rood, MD (1) · David Van Mater, MD (1) · Farid Boulad, MD (1) · Gregory Friedman, MD (1) · Ian F. Pollack, MD (1) · Ira Dunkel (1)
PMID 11807556, PMID 16533779, PMID 17019740, PMID 17634493, PMID 18281546, PMID 19065567, PMID 37553297, PMID 38182653, PMID 39586036, PMID 42270202
U01CA081457 (10), UM1CA081457 (8), 5UM1CA081457 (1)