12 completed, 5 terminated, 4 recruiting, 4 unknown. 30 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 30 | Completed 12, Terminated 5, Recruiting 4, Unknown 4, Active not recruiting 3, Withdrawn 2 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Retinoblastoma: new trials by email Literature Review of Retinoblastoma trials Research Report on Retinoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Retinoblastoma Phase II Expanded Access Clinical Trial Chemoplaque also referred to as Episcleral Topotecan - Retinoblastoma | Phase 2 | Recruiting | Targeted Therapy Technologies, LLC | 30 | 2025-02-21 | 2026-05-22 |
| A Study to Give Treatment Inside the Eye to Treat Retinoblastoma Biospecimen Collection, Carboplatin, Etoposide - Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma | Phase 2 | Recruiting | Children's Oncology Group | 26 | 2022-11-04 | 2026-08-25 |
| A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations ENV-101 (taladegib) - Solid Tumors With PTCH1 Loss-of-function Mutations | Phase 2 | Completed | Endeavor Biomedicines, Inc. | 20 | 2022-05-24 | 2026-03-05 |
| A Prospective International Multicenter Clinical Trial for Eyes With Relapsed Retinoblastoma Topotecan, Melphalan - Eye Cancer, Retinoblastoma | Phase 2 | Terminated | Prof. Beck Popovic Maja | 2 | 2021-11-15 | 2023-10-03 |
| A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma Conbercept ophthalmic injection - Retinoblastoma | Phase 2 | Unknown | Chengdu Kanghong Biotech Co., Ltd. | 92 | 2021-07-05 | 2021-08-04 |
| Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome Melphalan or Melphalan + Topotecan, etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy, Carboplatin administered on Day 1 - Retinoblastoma | Phase 2 / Phase 3 | Recruiting | Institut Curie | 225 | 2021-03-25 | 2025-11-28 |
| Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration Abemaciclib - Chondrosarcoma, Osteosarcoma | Phase 2 | Recruiting | Medical College of Wisconsin | 44 | 2019-10-07 | 2026-07-28 |
| Efficacy Study of Lucentis in the Treatment of Retinoblastoma Lucentis, chemotherapy, chemotherapy - Retinoblastoma | Phase 2 | Unknown | Sun Yat-sen University | 20 | 2013-07-01 | 2014-05-13 |
| Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma vincristine, topotecan, filgrastim - Retinoblastoma | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 174 | 2013-06-19 | 2026-06-29 |
| Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala Temozolomide - Retinoblastoma | Phase 2 | Terminated | Stanford University | 3 | 2012-03-01 | 2017-01-30 |
| Conservative Treatments of Retinoblastoma VP16, carboplatin, Melphalan, VP16, carboplatin, vincristin - Retinoblastoma, Children | Phase 2 | Active not recruiting | Institut Curie | 133 | 2012-02-01 | 2025-11-24 |
| Intra-arterial Chemotherapy for Children With Retinoblastoma Intra-arterial injection of melphalan, Injection of melphalan into the ophthalmic artery - Retinoblastoma | Phase 1 / Phase 2 | Unknown | Hadassah Medical Organization | 10 | 2011-06-01 | 2016-10-04 |
| Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma Melphalan hydrochloride - Retinoblastoma | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 10 | 2011-03-01 | 2018-11-27 |
| Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma Intra-arterial infusion of chemotherapy - Retinoblastoma, Eye Cancer | Phase 2 | Withdrawn | Stanford University | 2010-09-01 | 2012-05-14 | |
| Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009) Observation, Etoposide, Vincristine - Retinoblastoma | Phase 2 | Active not recruiting | Institut Curie | 195 | 2010-03-18 | 2026-01-07 |
| Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage Melphalan - Retinoblastoma | Phase 2 | Terminated | Hospital Sant Joan de Deu | 5 | 2009-11-01 | 2016-08-02 |
| Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors cixutumumab, laboratory biomarker analysis - Adult Rhabdomyosarcoma, Adult Synovial Sarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 116 | 2009-01-01 | 2015-03-30 |
| Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma Proton Beam Radiation Therapy, Ophthalmic EUA - Retinoblastoma | Phase 2 | Terminated | M.D. Anderson Cancer Center | 2 | 2007-01-01 | 2015-02-27 |
| Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma Intra-arterial Chemotherapy - Retinoblastoma | Phase 1 / Phase 2 | Completed | Weill Medical College of Cornell University | 100 | 2006-05-01 | 2009-12-17 |
| Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer DNA analysis, immunologic technique, pharmacological study - Brain and Central Nervous System Tumors, Intraocular Melanoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 78 | 2006-01-01 | 2024-04-04 |
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Sarcoma (8) · Neuroblastoma (7) · Osteosarcoma (6) · Central Nervous System Neoplasms (5) · Medulloblastoma (4) · Ovarian Neoplasms (4) · Chondrosarcoma (3) · Desmoplastic Small Round Cell Tumor (3) · Eye Neoplasms (3) · Neuroectodermal Tumors, Primitive, Peripheral (3) · Rhabdomyosarcoma (3) · Testicular Neoplasms (3) · Wilms Tumor (3) · Astrocytoma (2)
Eye Diseases (30) · Eye Diseases, Hereditary (30) · Neoplasms (30) · Neoplasms by Histologic Type (30) · Neoplasms by Site (30) · Neoplasms, Germ Cell and Embryonal (30) · Neoplasms, Glandular and Epithelial (30) · Neoplasms, Nerve Tissue (30) · Retinal Diseases (30) · Neoplasms, Neuroepithelial (29) · Neuroectodermal Tumors (29) · Retinal Neoplasms (28) · Eye Neoplasms (27) · Neoplasms, Connective and Soft Tissue (8) · Endocrine Gland Neoplasms (6)
Carboplatin (13) · Etoposide (11) · Vincristine (10) · Filgrastim (7) · Melphalan (6) · Cyclophosphamide (5) · Topotecan (5) · Cryotherapy (4) · Thiotepa (4) · Drug Therapy (3) · Cisplatin (2) · Doxorubicin (2) · Granulocyte Colony-Stimulating Factor (2) · Mesna (2) · Peripheral Blood Stem Cell Transplantation (2)
Memorial Sloan Kettering Cancer Center (5) · Institut Curie (3) · St. Jude Children's Research Hospital (3) · National Cancer Institute (NCI) (2) · Stanford University (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Chengdu Kanghong Biotech Co., Ltd. (1) · Children's Oncology Group (1) · Endeavor Biomedicines, Inc. (1) · Hadassah Medical Organization (1) · Hospital Sant Joan de Deu (1) · M.D. Anderson Cancer Center (1) · Medical College of Wisconsin (1) · NYU Langone Health (1) · Prof. Beck Popovic Maja (1)
United States (20) · Canada (5) · Australia (3) · France (3) · China (2) · Switzerland (2) · Argentina (1) · Chile (1) · Guatemala (1) · India (1) · Israel (1) · Netherlands (1) · New Zealand (1) · Puerto Rico (1) · Singapore (1)
Carlos Rodriguez-Galindo, MD (3) · Brian H. Kushner, MD (2) · Ira Dunkel, MD (2) · Andreu Parareda, MD (1) · Anne-Isabelle Bertozzi-Salamon, MD (1) · Anne-Marie Langevin, MD (1) · Brenda L Gallie, MD (1) · Brenda Weigel, MD (1) · Carole Coze, MD (1) · Catherine Devoldere, MD (1) · Celine De Bouyn-Icher, MD (1) · Christophe Piguet, MD (1) · Claire Briandet, MD (1) · Claire Pluchart, MD (1)
P30CA008748 (2), P30CA021765 (2), 2009 (1), 2018 (1), P01CA023099 (1), U10CA098543 (1), U10CA180886 (1)