48 completed, 19 recruiting, 19 unknown, 14 terminated. 30 Phase 2, 24 Phase 1, 17 Not applicable, 7 Phase 3, 3 Early Phase 1.
Follow Retinal Neoplasms: new trials by email Literature Review of Retinal Neoplasms trials Research Report on Retinal Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Retinoblastoma Consolidation in Egyptians transpupillary thermotherapy, Cryotherapy, Brachytherapy - Retinoblastoma | Not yet recruiting | Assiut University | 150 | 2026-05-01 | 2026-04-15 | |
| Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis. Targeted Long-read sequencing - Retinoblastoma Bilateral, Retinoblastoma Unilateral | Recruiting | University of Washington | 100 | 2026-03-16 | 2026-03-18 | |
| High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed Topotecan, Collection of aqueous humor, Electroretinogram - Retinoblastoma, Retinoblastoma, Recurrent | Early Phase 1 | Recruiting | Eye & ENT Hospital of Fudan University | 10 | 2025-04-01 | 2025-05-15 |
| Retinoblastoma Phase II Expanded Access Clinical Trial Chemoplaque also referred to as Episcleral Topotecan - Retinoblastoma | Phase 2 | Recruiting | Targeted Therapy Technologies, LLC | 30 | 2025-02-21 | 2026-05-22 |
| Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma Targeting NUDT21 siRNA drugs - Retinoblastoma, Refractory | Early Phase 1 | Recruiting | Eye & ENT Hospital of Fudan University | 2 | 2024-12-20 | 2025-06-26 |
| Trilateral Retinoblastoma: Incidence and Outcomes Incidence and survival of trilateral retinoblastoma and the differences globally - Trilateral Retinoblastoma, Retinoblastoma | Recruiting | Amsterdam UMC, location VUmc | 4351 | 2024-01-01 | 2024-04-16 | |
| Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors Neuropsychological assesment, Psychosocial functioning and quality of life (questionnaires), Parental psychosocial functioning (questionnaires) - Retinoblastoma, Neurocognitive Dysfunction | Enrolling by invitation | Amsterdam University Medical Center | 240 | 2023-10-26 | 2025-12-04 | |
| GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma GPC2 CAR T cells - Refractory Neuroblastoma, Relapsed Neuroblastoma | Phase 1 | Enrolling by invitation | Stephan Grupp MD PhD | 45 | 2023-05-23 | 2026-08-14 |
| A Study to Give Treatment Inside the Eye to Treat Retinoblastoma Biospecimen Collection, Carboplatin, Etoposide - Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma | Phase 2 | Recruiting | Children's Oncology Group | 26 | 2022-11-04 | 2026-08-25 |
| Baby Detect : Genomic Newborn Screening Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1 | Completed | Centre Hospitalier Universitaire de Liege | 6824 | 2022-09-01 | 2025-08-12 | |
| Treatment of Intraocular Retinoblastoma Balloon technology;Microcatheter technology - Retinoblastoma | Unknown | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 1600 | 2022-06-20 | 2022-06-01 | |
| Photoscreening for Retinoblastoma Photoscreening - - Retinoblastoma | Not applicable | Withdrawn | Phoenix Children's Hospital | 2022-06-01 | 2025-09-26 | |
| A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations ENV-101 (taladegib) - Solid Tumors With PTCH1 Loss-of-function Mutations | Phase 2 | Completed | Endeavor Biomedicines, Inc. | 20 | 2022-05-24 | 2026-03-05 |
| A Prospective International Multicenter Clinical Trial for Eyes With Relapsed Retinoblastoma Topotecan, Melphalan - Eye Cancer, Retinoblastoma | Phase 2 | Terminated | Prof. Beck Popovic Maja | 2 | 2021-11-15 | 2023-10-03 |
| A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma Conbercept ophthalmic injection - Retinoblastoma | Phase 2 | Unknown | Chengdu Kanghong Biotech Co., Ltd. | 92 | 2021-07-05 | 2021-08-04 |
| Topotecan Episcleral Plaque for Treatment of Retinoblastoma Episcleral Topotecan - Retinoblastoma | Phase 1 | Unknown | Targeted Therapy Technologies, LLC | 42 | 2021-06-16 | 2023-10-31 |
| Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma Melphalan - Retinoblastoma, Extraocular | Not applicable | Recruiting | Eye & ENT Hospital of Fudan University | 18 | 2021-05-01 | 2025-02-25 |
| Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome Melphalan or Melphalan + Topotecan, etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy, Carboplatin administered on Day 1 - Retinoblastoma | Phase 2 / Phase 3 | Recruiting | Institut Curie | 225 | 2021-03-25 | 2025-11-28 |
| Topotecan and Melphalan for Retinoblastoma Topotecan, Melphalan - Retinoblastoma, Chemotherapy Effect | Phase 3 | Recruiting | Sun Yat-sen University | 50 | 2021-03-11 | 2021-03-16 |
| Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anesthetic Exposure - Preliminary Study Dexmedetomidine - Retinoblastoma | Not applicable | Unknown | Seoul National University Hospital | 60 | 2021-02-05 | 2023-04-24 |
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Retinoblastoma (117) · Neuroblastoma (28) · Sarcoma (21) · Wilms Tumor (18) · Medulloblastoma (17) · Osteosarcoma (17) · Rhabdomyosarcoma (15) · Central Nervous System Neoplasms (12) · Sarcoma, Ewing (12) · Hepatoblastoma (11) · Astrocytoma (10) · Rhabdoid Tumor (10) · Optic Nerve Glioma (8) · Familial ependymoma (7) · Glioma (7)
Neoplasms by Histologic Type (117) · Neoplasms by Site (117) · Neoplasms, Glandular and Epithelial (117) · Neoplasms, Nerve Tissue (117) · Eye Diseases (116) · Eye Diseases, Hereditary (116) · Neoplasms, Neuroepithelial (116) · Retinal Diseases (116) · Neuroectodermal Tumors (115) · Eye Neoplasms (112) · Neoplasms (111) · Neoplasms, Germ Cell and Embryonal (111) · Neoplasms, Connective and Soft Tissue (30) · Neuroectodermal Tumors, Primitive (28)
Carboplatin (26) · Etoposide (22) · Vincristine (18) · Filgrastim (14) · Melphalan (14) · Topotecan (11) · Granulocyte Colony-Stimulating Factor (10) · Cyclophosphamide (9) · Cryotherapy (7) · Thiotepa (7) · Busulfan (4) · Drug Therapy (4) · Mesna (4) · Peripheral Blood Stem Cell Transplantation (4) · Brachytherapy (3)
Memorial Sloan Kettering Cancer Center (10) · St. Jude Children's Research Hospital (10) · Sun Yat-sen University (9) · Children's Oncology Group (5) · National Cancer Institute (NCI) (5) · Amsterdam UMC, location VUmc (4) · Institut Curie (4) · Eye & ENT Hospital of Fudan University (3) · Hadassah Medical Organization (3) · Masonic Cancer Center, University of Minnesota (3) · Stanford University (3) · Children's Hospital Medical Center, Cincinnati (2) · Emory University (2) · Fondation Ophtalmologique Adolphe de Rothschild (2) · Seattle Children's Hospital (2)
United States (62) · China (13) · Canada (11) · France (6) · Netherlands (6) · Australia (4) · Argentina (3) · Israel (3) · South Korea (3) · Switzerland (3) · Chile (2) · Germany (2) · Guatemala (2) · Puerto Rico (2) · Spain (2)
Carlos Rodriguez-Galindo, MD (4) · Ira Dunkel, MD (3) · Brian H. Kushner, MD (2) · Huasheng Yang, Doctor (2) · Huasheng Yang, M.D, PHD (2) · James Geller, MD (2) · Jiang Qian, MD (2) · Kim Kramer, MD (2) · Rachel Brennan, MD (2) · Abdussalam Abdussalam, PhD (1) · Andreu Parareda, MD (1) · Andrew Cluster, M.D. (1) · Andrew W Stacey, MD (1) · Anne-Isabelle Bertozzi-Salamon, MD (1) · Anne-Marie Langevin, MD (1)
PMID 31401903, PMID 15814645, PMID 16533779, PMID 17610262, PMID 18048828, PMID 18064739, PMID 18342944, PMID 18391430, PMID 18978345, PMID 19542994, PMID 21319349, PMID 23668238, PMID 25179634, PMID 25325870, PMID 25565164, PMID 26154941, PMID 26671110, PMID 27371184, PMID 27748655, PMID 30061186, PMID 31315600, PMID 31876107, PMID 32105305, PMID 32223740, PMID 32434859, PMID 32799607, PMID 33062393, PMID 33507604, PMID 33805776, PMID 35142618, PMID 35839812, PMID 37344582, PMID 39095033, PMID 39255444, PMID 39432296, PMID 41026583
U10CA098543 (3), P01CA023099 (2), P30CA008748 (2), P30CA021765 (2), 2009 (1), 2017 (1), 2018 (1), K08EY033789 (1), P30CA022453 (1), R01CA225005 (1), R01CA282759 (1), R01EY018599 (1), R21CA217268 (1), R37CA282041 (1), U01CA097452 (1)