431 completed, 82 terminated, 74 unknown, 47 recruiting. 700 Phase 3, 105 Phase 2.
Follow Renal Insufficiency: new trials by email Literature Review of Renal Insufficiency trials Research Report on Renal Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease Treated With Once Daily Basal Insulin Alone or in Combination With Metformin, SGLT2i, or Both Placebo, Zenagamtide - Type 2 Diabetes, Chronic Kidney Disease | Phase 3 | Not yet recruiting | Novo Nordisk A/S | 450 | 2026-11-10 | 2026-11-12 |
| Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis 2 (SAFE-D2) Eliquis, No oral anticoagulation - Atrial Fibrillation, Atrial Flutter | Phase 3 | Not yet recruiting | Unity Health Toronto | 848 | 2026-11-01 | 2026-08-21 |
| Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients Ramipril tablet, Amlodipine tablet - Endothelial Dysfunction, End-Stage Renal Disease | Phase 3 | Not yet recruiting | Ain Shams University | 50 | 2026-11-01 | 2026-10-21 |
| A Study of PLS240 in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis PLS240, Standard of Care - Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism | Phase 3 | Not yet recruiting | Pathalys Pharma | 56 | 2026-10-30 | 2026-10-22 |
| Study of Tegoprubart Efficacy and Safety Compared With Tacrolimus in Kidney Transplantation Tegoprubart, Tacrolimus - Kidney Transplant Rejection | Phase 3 | Not yet recruiting | Eledon Pharmaceuticals | 620 | 2026-10-01 | 2026-09-30 |
| A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD) Balcinrenone/dapagliflozin, Dapagliflozin, Placebo matching Dapagliflozin - Renal Insufficiency, Chronic | Phase 3 | Recruiting | AstraZeneca | 2800 | 2026-09-01 | 2026-09-24 |
| Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal Hypertonic sodium chloride 10%, Sodium Chloride 0.9%, Furosemide intravenous solution - Heart Failure, Renal Disease, Chronic | Phase 3 | Not yet recruiting | University of Monastir | 60 | 2026-09-01 | 2026-07-15 |
| A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease. Elecoglipron, Placebo - Chronic Kidney Disease | Phase 3 | Recruiting | AstraZeneca | 7000 | 2026-08-21 | 2026-09-09 |
| Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Atrasentan in Pediatric Patients With Primary IgAN Drug: Atrasentan - Berger Disease, Bergers Disease | Phase 3 | Recruiting | Novartis Pharmaceuticals | 28 | 2026-08-06 | 2026-11-06 |
| Renal Efficacy and Safety of the Novel Oral Small-Molecule GLP-1RA HRS-7535 Evaluated in Participants With Chronic Kidney Disease HRS-7535, Placebo - Chronic Kidney Disease | Phase 3 | Not yet recruiting | Shandong Suncadia Medicine Co., Ltd. | 3690 | 2026-07-01 | 2026-06-04 |
| Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF) QRX-3 - Acute Renal Failure (ARF), Acute Tubular Necrosis | Phase 2 / Phase 3 | Not yet recruiting | Ebima Clifford Okundaye | 500 | 2026-06-30 | 2026-02-18 |
| A Study to Determine if BHV-1400 is Effective and Safe in Adults With IgA Nephropathy BHV-1400, Placebo - IgA Nephropathy | Phase 3 | Not yet recruiting | Biohaven Therapeutics Ltd. | 420 | 2026-06-01 | 2026-06-11 |
| Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults at High Risk of Delayed Graft Function (DGF) Following Kidney Allograft Transplantation Pegcetacoplan, Placebo - Delayed Graft Function, End Stage Renal Disease | Phase 3 | Withdrawn | Apellis Pharmaceuticals, Inc. | 2026-05-18 | 2026-09-02 | |
| Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT Phosphate-containing Replacement Fluid, Standard Phosphate-free Replacement Fluid - Acute Kidney Injury, Sepsis | Phase 3 | Not yet recruiting | Sun Yat-sen University | 220 | 2026-05-01 | 2026-04-24 |
| A Phase III Clinical Study on the Efficacy and Safety of HRS-1780 in the Treatment of Patients With Chronic Kidney Disease HRS-1780 tablets, Placebo - Chronic Kidney Disease | Phase 3 | Recruiting | Shandong Suncadia Medicine Co., Ltd. | 5386 | 2026-03-13 | 2026-07-17 |
| FINE-START: Efficacy and Safety of Finerenone in Patients With Chronic Kidney Disease Not Using Renin-angiotensin-system Inhibitors Finerenone (BAY 94-8862), Placebo - Chronic Kidney Disease | Phase 3 | Enrolling by invitation | University Medical Center Groningen | 180 | 2026-03-13 | 2026-04-14 |
| Probiotics Against Erythropoietin Resistance in Chronic Kidney Disease Patients. Erythropoietin + Probiotic, EPO - Anaemia, Chronic Kidney Disease | Phase 3 | Completed | Badr University | 80 | 2026-02-01 | 2026-10-30 |
| Ketoanalogue Supplementation for Muscle Protection in CKD 4 and 5 Patients With Moderately Low Protein Diet (KETO-PROT-ACTION) Keto Acid - Kidney Disease, Chronic | Phase 3 | Recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-01-05 | 2026-01-28 |
| A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids) Empagliflozin, Placebo - Chronic Kidney Disease | Phase 3 | Active not recruiting | Boehringer Ingelheim | 135 | 2025-12-09 | 2026-11-10 |
| Dapagliflozin for Cardio-renal Protection After ICU Discharge Dapagliflozin 10 MG Oral Tablet [Farxiga], One tablet of placebo of dapagliflozin 10 mg - Heart Failure and Chronic Kidney Disease Post-ICU | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 600 | 2025-12-02 | 2026-02-23 |
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Renal Insufficiency, Chronic (356) · Kidney Failure, Chronic (196) · Acute Kidney Injury (102) · Anemia (80) · Kidney Diseases (58) · Hyperphosphatemia (37) · Diabetes Mellitus, Type 2 (35) · Heart Failure (30) · Hyperparathyroidism, Secondary (29) · Hypertension (17) · Diabetes Mellitus (15) · Cardiovascular Diseases (14) · Proteinuria (12) · Anemia, Iron-Deficiency (11)
Female Urogenital Diseases (699) · Female Urogenital Diseases and Pregnancy Complications (699) · Male Urogenital Diseases (699) · Urogenital Diseases (699) · Urologic Diseases (694) · Kidney Diseases (642) · Pathological Conditions, Signs and Symptoms (553) · Pathologic Processes (546) · Disease Attributes (516) · Chronic Disease (504) · Renal Insufficiency, Chronic (147) · Nutritional and Metabolic Diseases (134) · Metabolic Diseases (123) · Cardiovascular Diseases (98)
Darbepoetin alfa (30) · Sodium Chloride (21) · Epoetin Alfa (20) · Sevelamer (20) · Tacrolimus (17) · dapagliflozin (17) · Saline Solution (15) · paricalcitol (15) · Cinacalcet (14) · Acetylcysteine (12) · roxadustat (12) · ferric citrate (11) · Sodium Bicarbonate (10) · Standard of Care (10) · cholebine (9)
Amgen (33) · Tanabe Pharma Corporation (12) · Bayer (11) · AstraZeneca (9) · Novartis Pharmaceuticals (9) · Akebia Therapeutics (8) · Astellas Pharma Inc (8) · GlaxoSmithKline (8) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (8) · Abbott (7) · Genzyme, a Sanofi Company (7) · Pfizer (7) · AbbVie (6) · Assistance Publique - Hôpitaux de Paris (6) · Cara Therapeutics, Inc. (6)
United States (273) · France (113) · Germany (111) · Italy (105) · Spain (102) · Poland (97) · Canada (95) · United Kingdom (85) · Australia (67) · Brazil (63) · South Korea (61) · Czechia (60) · Mexico (60) · Hungary (59) · Russia (56)
Joel Melnick, MD (4) · Vice President, Clinical Development (4) · Barry Massie, MD (3)
PMID 36005278, PMID 40576086, PMID 36791280, PMID 35224730, PMID 37916745, PMID 38770818, PMID 39607014, PMID 23343061, PMID 23343062, PMID 32734207, PMID 36039153, PMID 37651553, PMID 39356039, PMID 39878152, PMID 40359056, PMID 18926433, PMID 20925544, PMID 21545947, PMID 31203241, PMID 33107592, PMID 33586138, PMID 34519356, PMID 36416787, PMID 36749544, PMID 37872654, PMID 37968132, PMID 38299639, PMID 38363466, PMID 38622766, PMID 38682786, PMID 39037824, PMID 39301879, PMID 39963952, PMID 40526444, PMID 40658498, PMID 41196655, PMID 41198855, PMID 42335037, PMID 10400005, PMID 18477783, PMID 18591942, PMID 19339093, PMID 21900185, PMID 22339573, PMID 22422538, PMID 23149295, PMID 23332990, PMID 23970131, PMID 24281134, PMID 24281137
2023 (12), 2016 (11), 2015 (8), 2017 (6), 2018 (5), 2008 (4), 2009 (4), 2025 (4), 2014 (3), 2004 (2), U01DK058982 (2), U01DK066597 (2), 1KL2RR025015-01 (1), 2005 (1), 2019 (1)