491 completed, 98 terminated, 90 unknown, 81 recruiting. 862 Phase 2, 130 Phase 1, 105 Phase 3.
Follow Renal Insufficiency: new trials by email Literature Review of Renal Insufficiency trials Research Report on Renal Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Amino Acid Therapy Evaluating the Incidence of New-Onset AKI Amino Acid infusion, Lactated Ringer Solution - Acute Kidney Injury | Phase 2 | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 270 | 2027-10-01 | 2026-10-21 |
| Breakthrough - T1DM and Chronic Kidney Disease Tegoprubart, Islet Cell Transplant - Diabete Type 1, Chronic Kidney Disease | Phase 1 / Phase 2 | Recruiting | University of Chicago | 10 | 2027-04-29 | 2026-08-20 |
| Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis Bupropion Hydrochloride 150 MG - End Stage Renal Disease, Fatigue | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 16 | 2027-02-01 | 2026-11-02 |
| Nicotinamide Riboside Supplementation in Chronic Kidney Disease Nicotinamide Riboside (NR), Matched Placebo (Capsules) - Chronic Kidney Disease | Phase 2 | Not yet recruiting | University of California, San Diego | 30 | 2027-01-15 | 2026-11-12 |
| Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM) | Phase 2 | Not yet recruiting | HealthPartners Institute | 80 | 2027-01-01 | 2026-10-23 |
| Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia. Spironolactone (drug), Iron Supplement, Erythropoietin stimulating agent - Anemia | Phase 2 | Not yet recruiting | Ain Shams University | 40 | 2026-12-01 | 2026-07-20 |
| Study to Evaluate the Safety and Efficacy of the GGTA1 KO Thymokidney in Patients With ESRD GGTA1 KO Thymokidney - ESRD (End-Stage Renal Disease), Kidney Transplantation | Phase 1 / Phase 2 | Recruiting | United Therapeutics | 50 | 2026-11-01 | 2026-09-09 |
| Ticagrelor for Inflammation and Cardiovascular Risk in Patients With Chronic Kidney Disease Ticagrelor: an oral, direct-acting, reversibly binding P2Y12 receptor antagonist, Placebo - Chronic Kidney Disease (CKD) | Phase 2 | Recruiting | University of Arkansas | 230 | 2026-11-01 | 2026-11-10 |
| REducing Systemic Inflammation With LOw-dose Colchicine to ImproVE Cardiovascular Calcification in Chronic Kidney Disease: A Pilot Randomized Open-Label Trial Low-dose Colchicine at 0.5mg daily, Usual Care - Chronic Kidney Disease Mineral and Bone Disorder, Cognitive Function | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-10-30 | 2026-11-04 |
| Evaluate the Efficacy and Safety of ABP-671 in Subjects With Chronic Kidney Disease and Hyperuricaemia ABP-671 plus febuxostat Group 1, ABP-671 plus febuxostat Group 2, ABP-671 Group - Chronic Kidney Disease | Phase 2 | Recruiting | Atom Therapeutics Co., Ltd | 80 | 2026-10-02 | 2026-11-02 |
| LOw DosE Spironolactone, chlorThAlidone oR Combination in CKD Trial phase 2A Chlorthalidone, phase 2A Spironolactone, phase 2A Chlorthalidone + Spironolactone - Hypertension Treated With Antihypertensive Drugs, Chronic Kidney Disease, 3B and 4 | Phase 2 | Not yet recruiting | VA Office of Research and Development | 160 | 2026-10-01 | 2026-06-12 |
| Efficacy and Safety of SP16 in Preventing Acute Kidney Injury in At-risk Subjects With Chronic Kidney Disease Undergoing Elective Cardiac Surgery Using the Heart-lung-machine SP16-3M, Placebo - AKI - Acute Kidney Injury | Phase 2 | Recruiting | University of Erlangen-Nürnberg Medical School | 120 | 2026-09-14 | 2026-09-24 |
| Terbinafine for CSA-AKI Prevention Terbinafine - Acute Kidney Injury, Cardiac Surgical Procedures | Phase 2 | Not yet recruiting | Guangdong Provincial People's Hospital | 208 | 2026-09-01 | 2026-07-31 |
| A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event Clazakizumab, Placebo - Atherosclerosis, Cardiovascular Disease | Phase 2 | Recruiting | Eli Lilly and Company | 120 | 2026-08-27 | 2026-11-03 |
| Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus Difelikefalin - Pruritus, Chronic Kidney Diseases | Phase 2 | Recruiting | Vifor Fresenius Medical Care Renal Pharma | 18 | 2026-08-04 | 2026-10-23 |
| A Study of Luspatercept in People With Anemia Luspatercept - Anemia, Chronic Kidney Disease | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2026-07-20 | 2026-10-13 |
| Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy Amino Acid infusion, Lactated ringers solution - Acute Kidney Injury, Mechanical Ventilation | Phase 2 | Recruiting | Dana Fuhrman | 30 | 2026-07-08 | 2026-07-24 |
| Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease Anakinra (interleukin-1 receptor antagonist), Placebo Comparator (0.9% NaCl) - Postprandial Hypoglycemia, End-stage Renal Disease (ESRD) | Phase 2 | Not yet recruiting | Marc Donath | 1 | 2026-07-01 | 2026-05-12 |
| Mesenchymal Stem Cell Exosomes Alone or Combined With HUVEC Exosomes in Non-Dialysis Chronic Kidney Disease Human Wharton's jelly mesenchymal stem cell (HWJ-MSC) exosomes, Human umbilical vein endothelial cell (HUVEC) exosomes, Placebo (0.9% sodium chloride) - Chronic Kidney Disease Stage 3, Chronic Kidney Disease Stage 4 | Phase 1 / Phase 2 | Completed | Nurhasan Agung Prabowo | 34 | 2026-07-01 | 2026-11-06 |
| Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF) QRX-3 - Acute Renal Failure (ARF), Acute Tubular Necrosis | Phase 2 / Phase 3 | Not yet recruiting | Ebima Clifford Okundaye | 500 | 2026-06-30 | 2026-02-18 |
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Renal Insufficiency, Chronic (364) · Kidney Failure, Chronic (273) · Acute Kidney Injury (154) · Anemia (65) · Kidney Diseases (45) · Diabetes Mellitus, Type 2 (36) · Heart Failure (30) · Diabetic Nephropathies (28) · Inflammation (23) · Diabetes Mellitus (21) · Hypertension (20) · Proteinuria (20) · Cardiovascular Diseases (18) · Hyperphosphatemia (18)
Female Urogenital Diseases (862) · Female Urogenital Diseases and Pregnancy Complications (862) · Male Urogenital Diseases (862) · Urogenital Diseases (861) · Urologic Diseases (860) · Kidney Diseases (817) · Pathological Conditions, Signs and Symptoms (658) · Pathologic Processes (652) · Disease Attributes (603) · Chronic Disease (592) · Renal Insufficiency, Chronic (228) · Nutritional and Metabolic Diseases (132) · Cardiovascular Diseases (120) · Metabolic Diseases (116)
Saline Solution (25) · dapagliflozin (24) · Sodium Chloride (22) · Tacrolimus (17) · Spironolactone (14) · Sevelamer (13) · Epoetin Alfa (12) · Mycophenolic Acid (12) · Acetylcysteine (11) · Sirolimus (11) · empagliflozin (11) · Dexamethasone (10) · Sodium Bicarbonate (10) · Exercise (9) · Rituximab (9)
Vanderbilt University (18) · Novartis Pharmaceuticals (17) · Bayer (12) · AstraZeneca (10) · Mayo Clinic (10) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (10) · GlaxoSmithKline (9) · Affymax (7) · Akebia Therapeutics (7) · Amgen (7) · Iperboreal Pharma Srl (7) · Mansoura University (7) · Rockwell Medical Technologies, Inc. (7) · University of Washington (7) · VA Office of Research and Development (7)
United States (419) · Canada (79) · Germany (74) · United Kingdom (70) · France (65) · Spain (65) · Italy (57) · Japan (48) · China (45) · Australia (44) · Poland (40) · Denmark (36) · Belgium (33) · Brazil (31) · Czechia (30)
Alp Ikizler, MD (16) · Mario Bonomini, MD (4) · Vice President, Clinical Development (4) · Arduino Arduini, MD (3)
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