21 completed, 2 recruiting, 1 active not recruiting, 1 suspended. 14 Phase 3, 6 Phase 4, 5 Phase 2, 1 Not applicable, 1 Phase 1.
Follow ferric citrate: new trials by email Literature Review of ferric citrate trials Research Report on ferric citrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ferric Citrate in Iron Deficiency Anemia During Pregnancy Ferric citrate 210 mg, Ferrous fumarate 200 mg - Anemia | Phase 3 | Recruiting | Dhaka Medical College | 680 | 2026-02-01 | 2026-09-15 |
| Study to Evaluate the Safety and Tolerability of KRX-0502 (Ferric Citrate) in Children With Iron Deficiency Anemia Associated With Non-Dialysis Dependent Chronic Kidney Disease ferric citrate, standard of care - Iron Deficiency Anemia Associated With Non-Dialysis Dependent Chronic Kidney Disease | Phase 3 | Withdrawn | Keryx Biopharmaceuticals | 2025-01-01 | 2025-11-20 | |
| Ferric Citrate and Chronic Kidney Disease in Children Ferric Citrate, Placebo - Chronic Kidney Diseases | Phase 2 | Recruiting | University of California, Los Angeles | 160 | 2022-06-17 | 2026-04-17 |
| Study to Evaluate the Safety and Tolerability of Ferric Citrate in Children With Hyperphosphatemia Related to Chronic Kidney Disease ferric citrate - Hyperphosphatemia Related to Chronic Kidney Disease | Phase 3 | Suspended | Keryx Biopharmaceuticals | 45 | 2022-06-16 | 2026-06-22 |
| Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney Disease Ferric Citrate 1 GM Oral Tablet [AURYXIA], Placebo - Anemia, Iron Deficiency, Hyperphosphatemia | Phase 3 | Completed | USRC Kidney Research | 289 | 2022-03-30 | 2025-08-29 |
| Auryxia (Ferric Citrate) Therapy for In-Center and Home Dialysis Participants Ferric Citrate 1 gram Oral Tablet, Standard of care phosphate-lowering therapy - Hyperphosphatemia, Anemia, Iron Deficiency | Phase 4 | Completed | USRC Kidney Research | 214 | 2021-06-29 | 2022-11-07 |
| PBF-1681 (Ferric Citrate) for the Treatment of IDA in Patients With NDD-CKD Ferric citrate, Placebo - Anemia of Chronic Kidney Disease | Phase 3 | Completed | Panion & BF Biotech Inc. | 141 | 2020-10-14 | 2025-06-29 |
| Study in Healthy Adult Subjects to Assess the Effect of Phosphate Binders on the Pharmacokinetics of a Single Dose of Vadadustat Vadadustat, Sevelamer carbonate, Calcium acetate - Healthy Volunteers | Phase 1 | Completed | Akebia Therapeutics | 54 | 2020-06-15 | 2020-10-08 |
| Ferric Citrate for the Treatment of Hyperphosphatemia in Patients With Chronic Kidney Disease Undergoing Hemodialysis Ferric Citrate, Sevelamer Carbonate - Hyperphosphatemia, End Stage Renal Disease | Phase 3 | Completed | Panion & BF Biotech Inc. | 240 | 2019-06-19 | 2021-03-10 |
| Ferric Citrate for the Treatment of Hyperphosphatemia in Patients With Chronic Kidney Disease Undergoing Hemodialysis Ferric citrate tablet, Sevelamer carbonate tablet - Hyperphosphatemia, End Stage Renal Disease | Phase 3 | Completed | Sinomune Pharmaceutical Co., Ltd | 239 | 2019-05-24 | 2024-04-17 |
| Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy Tenapanor, Placebo, Phosphate Binder Agents - Hyperphosphatemia | Phase 2 / Phase 3 | Completed | Ardelyx | 236 | 2019-02-28 | 2023-03-06 |
| KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) KRX-0502 - Chronic Kidney Diseases, Iron Deficiency Anemia | Phase 4 | Completed | Keryx Biopharmaceuticals | 206 | 2017-08-15 | 2021-03-12 |
| Ferric Citrate in ESRD Pilot Project Ferric Citrate - End Stage Renal Disease, Chronic Kidney Diseases | Phase 4 | Active not recruiting | Sreedhar Mandayam | 30 | 2017-05-11 | 2019-04-17 |
| Transition to Ferric Citrate Among Hemodialysis and Peritoneal Dialysis Patients Ferric Citrate - Hyperphosphatemia | Phase 4 | Completed | Kaiser Permanente | 55 | 2017-05-01 | 2022-01-13 |
| Assess the Safety and Efficacy of Nephoxil® in Subjects With End Stage Renal Disease (ESRD) on Dialysis Ferric Citrate - Kidney Failure, Chronic, End-stage Renal Disease | Phase 4 | Completed | Panion & BF Biotech Inc. | 202 | 2017-04-12 | 2020-01-13 |
| Impact of Ferric Citrate vs Ferrous Sulfate on Iron Parameters and Hemoglobin in Individuals With CKD and Iron Deficiency ferric citrate, ferrous sulfate - Chronic Kidney Disease, Iron Deficiency | Not applicable | Completed | University of Alabama at Birmingham | 60 | 2016-09-01 | 2020-03-24 |
| A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Ferric Citrate - End Stage Renal Disease, Hyperphosphatemia | Phase 4 | Terminated | Winthrop University Hospital | 38 | 2015-07-01 | 2023-04-20 |
| Ferric Citrate for the Transition From CKD Stage 4/5 to CKD Stage 5D Ferric Citrate - Chronic Kidney Disease, Hyperphosphatemia | Phase 3 | Completed | Denver Nephrologists, P.C. | 200 | 2015-03-01 | 2018-08-01 |
| KRX-0502 (Ferric Citrate) for the Treatment of IDA in Adult Subjects With NDD-CKD ferric citrate, Placebo - Anemia of Chronic Kidney Disease | Phase 3 | Completed | Keryx Biopharmaceuticals | 234 | 2014-10-01 | 2018-03-22 |
| A Pilot Study of KRX-0502 (Ferric Citrate, Administered Without Food, in Treating Iron-deficiency Anemia KRX-0502 - Anemia of Chronic Kidney Disease | Phase 2 | Completed | Keryx Biopharmaceuticals | 32 | 2014-04-01 | 2018-08-24 |
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Hyperphosphatemia (16) · Renal Insufficiency, Chronic (14) · Kidney Failure, Chronic (11) · Renal Insufficiency (8) · Anemia, Iron-Deficiency (6) · Anemia (4) · Iron Deficiencies (3) · Kidney Diseases (3) · Phosphorus Metabolism Disorders (3) · Urologic Diseases (2) · Diabetes Mellitus (1) · Disease Progression (1) · Metabolic Diseases (1)
Keryx Biopharmaceuticals (11) · Panion & BF Biotech Inc. (4) · USRC Kidney Research (2) · Akebia Therapeutics (1) · Ardelyx (1) · Denver Nephrologists, P.C. (1) · Dhaka Medical College (1) · Kaiser Permanente (1) · Sinomune Pharmaceutical Co., Ltd (1) · Sreedhar Mandayam (1) · University of Alabama at Birmingham (1) · University of California, Los Angeles (1) · Winthrop University Hospital (1)
United States (17) · Israel (3) · Puerto Rico (3) · Taiwan (3) · Canada (2) · China (2) · Bangladesh (1)
Julia B Lewis, MD (4) · Geoffrey Block, MD (2) · Glenn Chertow, MD (2) · Steven Fishbane, MD (2) · Candace Grant, MD (1) · David P Rosenbaum, PhD (1) · Geoff Block, MD (1) · Geoffrey A Block, MD (1) · Isidro B Salusky, MD (1) · Itamar Raz, MD (1) · Mai-Szu Wu, M.D. (1) · Mei-I Wu, MD, PhD (1) · Orlando M Gutierrez, MD (1)
PMID 40576086, PMID 23369827, PMID 24840781, PMID 25468387, PMID 26239948, PMID 32694162, PMID 33766811, PMID 35237863, PMID 35239732, PMID 38323855, PMID 38972306
U01DK122013 (1)