162 completed, 28 unknown, 20 recruiting, 17 terminated. 49 Phase 4, 46 Phase 3, 41 Phase 2, 28 Not applicable, 18 Phase 1.
Follow Hyperparathyroidism, Secondary: new trials by email Literature Review of Hyperparathyroidism, Secondary trials Research Report on Hyperparathyroidism, Secondary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of PLS240 in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis PLS240, Standard of Care - Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism | Phase 3 | Not yet recruiting | Pathalys Pharma | 56 | 2026-10-30 | 2026-10-22 |
| Osteoporosis & Renal Disease: Research in Primary Health Care Services Fracture risk assessment tool (FRAX), Dual-Energy X-ray Absorptiometry (DXA) - Osteoporosis, Chronic Kidney Disease Mineral and Bone Disorder | Not yet recruiting | Universidade do Porto | 622 | 2026-10-01 | 2026-09-30 | |
| Hyperparathyroidism and Dialysis Adequacy in Hemodialysis Patients Hyperparathyroidism, Secondary, Kidney Failure, Chronic | Not yet recruiting | Assiut University | 130 | 2026-09-10 | 2026-09-15 | |
| Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants CTAP101 - CKD Stage 3, CKD Stage 4 | Phase 2 | Recruiting | OPKO Health, Inc. | 40 | 2026-08-05 | 2026-08-20 |
| Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD Low-dose Colchicine at 0.5mg daily, Usual Care - Chronic Kidney Disease Mineral and Bone Disorder, Hypertension | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-07-01 | 2026-06-22 |
| Medium Cut-Off and High-Flux Membranes on Mineral and Bone Metabolism in Hemodialysis Patients Medium Cut-Off Hemodialysis Membrane, High-Flux Hemodialysis Membrane - End Stage Kidney Disease (ESKD), Hemodialysis | Not applicable | Active not recruiting | Gazi University | 30 | 2026-07-01 | 2026-09-14 |
| Calcium Isotope Ratios to Assess Calcium Bone Balance in Dialysis Children Receiving Cinacalcet Supplementary blood samples and urines samples - Children Over 3 Undergoing Dialysis With Secondary Hyperparathyroidism | Recruiting | Hospices Civils de Lyon | 20 | 2026-04-29 | 2026-05-22 | |
| The CPH-MBD Cohort Chronic Kidney Disease Mineral and Bone Disorder, Chronic Kidney Disease (CKD) | Recruiting | Herlev Hospital | 1000 | 2026-01-07 | 2026-09-16 | |
| The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations CKD, Renal Insufficiency Chronic | Recruiting | University of Copenhagen | 50 | 2025-12-15 | 2025-12-31 | |
| The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density Treat to target - Chronic Kidney Disease Mineral and Bone Disorder | Not applicable | Recruiting | Herlev Hospital | 70 | 2025-11-20 | 2026-01-06 |
| Study of MT1013 for the Treatment of Patients With Secondary Hyperparathyroidism MT1013, Cinacalcet - Secondary Hyperparathyroidism, Chronic Kidney Disease | Phase 3 | Recruiting | Shaanxi Micot Pharmaceutical Technology Co., Ltd. | 424 | 2025-09-30 | 2025-10-01 |
| Activated Charcoal Use in Chronic Kidney Disease Patients Activated Charcoal, Phosphate Binders - End Stage Renal Disease (ESRD), CKD 5D, Hemodialysis | Phase 2 | Recruiting | Mansoura University | 40 | 2025-08-01 | 2025-08-08 |
| Phosphate Assessment in Chronic Kidney Disease Patients Study Dietary Phosphorus Intake - Chronic Kidney Disease (Stage 3-4), Chronic Kidney Disease Mineral and Bone Disorder | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 60 | 2025-05-09 | 2026-01-28 |
| Assessment of Mineral and Bone Disorders in Kidney Transplant Recipients Hemodyalysis, Kidney Tansplant | Recruiting | Grigore T. Popa University of Medicine and Pharmacy | 180 | 2025-03-19 | 2025-08-26 | |
| Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease Resistance Exercise, Aerobic Training - Osteopenia, Bone Metabolism Disorders | Not applicable | Completed | Sinai University | 60 | 2025-01-01 | 2025-08-21 |
| A Mass Balance Study of [14C] SHR6508 in Chinese Hemodialysis Subjects With Secondary Hyperparathyroidism [14C] SHR6508 Injection - Secondary Hyperparathyroidism | Phase 1 | Completed | Shanghai Hengrui Pharmaceutical Co., Ltd. | 5 | 2024-12-23 | 2026-03-23 |
| MT1013 Injection for the Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease MT1013, Etelcalcetide Hydrochloride, Placebo - Secondary Hyperparathyroidism (SHPT) in Subjects With Chronic Kidney Disease (CKD) on Hemodialysis | Phase 2 | Completed | Shaanxi Micot Pharmaceutical Technology Co., Ltd. | 115 | 2024-11-04 | 2026-07-22 |
| Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdism Intraoperative parathyroid hormone (IOPTH) monitoring - Secondary Hyperparathyroidism, Tertiary Hyperparathyroidism | Not applicable | Unknown | McMaster University | 60 | 2024-10-01 | 2024-08-07 |
| The Effect of Increasing Dialysate Calcium on T50 in Subjects With Secondary Hyperparathyroidism and ESKD Dialysate calcium 1.50 mmol/L - Secondary Hyperparathyroidism, End-stage Kidney Disease | Phase 2 | Unknown | Iain Bressendorff | 48 | 2024-08-01 | 2024-05-03 |
| The Trial of SHR6508 in Secondary Hyperparathyroidism SHR6508 plus oral placebo tablets, Cinacalcet plus intravenous placebo - Secondary Hyperparathyroidism | Phase 3 | Completed | Shanghai Hengrui Pharmaceutical Co., Ltd. | 498 | 2024-06-14 | 2025-12-12 |
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Renal Insufficiency, Chronic (95) · Chronic Kidney Disease-Mineral and Bone Disorder (73) · Kidney Failure, Chronic (45) · Hyperparathyroidism (24) · Renal Insufficiency (15) · Vitamin D Deficiency (15) · Kidney Diseases (13) · Vascular Calcification (10) · Hyperphosphatemia (9) · Hypocalcemia (9) · Osteoporosis (8) · Parathyroid Diseases (8) · Bone Diseases (6) · Hypercalcemia (6)
Endocrine System Diseases (242) · Parathyroid Diseases (234) · Hyperparathyroidism (218) · Male Urogenital Diseases (164) · Pathological Conditions, Signs and Symptoms (164) · Female Urogenital Diseases (163) · Female Urogenital Diseases and Pregnancy Complications (163) · Urogenital Diseases (163) · Urologic Diseases (163) · Pathologic Processes (162) · Disease Attributes (161) · Chronic Disease (160) · Kidney Diseases (150) · Renal Insufficiency (114) · Nutritional and Metabolic Diseases (105)
Cinacalcet (40) · paricalcitol (33) · etelcalcetide hydrochloride (18) · Calcitriol (15) · 1 alpha-hydroxyergocalciferol (14) · Standard of Care (8) · Cholecalciferol (6) · Sevelamer (6) · Calcifediol (5) · Vitamin D (5) · alfacalcidol (4) · Calcium Carbonate (3) · Denosumab (3) · Ergocalciferols (3) · Teriparatide (3)
Amgen (34) · Abbott (13) · AbbVie (prior sponsor, Abbott) (12) · Kyowa Kirin Co., Ltd. (7) · OPKO Health, Inc. (7) · KAI Pharmaceuticals (5) · OPKO IP Holdings II, Inc. (5) · Shanghai Hengrui Pharmaceutical Co., Ltd. (5) · Genzyme, a Sanofi Company (4) · Shaanxi Micot Pharmaceutical Technology Co., Ltd. (4) · University of Sao Paulo General Hospital (4) · Washington University School of Medicine (4) · Herlev Hospital (3) · Pathalys Pharma (3) · Sanwa Kagaku Kenkyusho Co., Ltd. (3)
United States (78) · China (29) · Germany (18) · Japan (18) · Poland (17) · Italy (16) · Spain (16) · Russia (14) · Denmark (13) · France (13) · Belgium (12) · Czechia (12) · Hungary (11) · Austria (10) · Greece (10)
Joel Melnick, MD (7) · M D (3) · Ann Eldred, MD (2) · Christos Argyropoulos, MD (2) · Ditte Hansen, MD, PhD (2) · Ditte Hansen, Medical doctor, professor (2) · Efstathios Mitsopoulos, MD (2) · Gregory Bell, MD (2) · Jing Chen (2) · Jing Chen, MD (2) · Ravi Thadhani, MD (2) · Tadao Akizawa, MD, PhD (2) · Thomas Nickolas, MD, MS (2)
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