7 completed, 4 recruiting, 2 unknown, 2 withdrawn. 8 Phase 2, 7 Not applicable, 1 Early Phase 1.
Follow Radiation Fibrosis Syndrome: new trials by email Literature Review of Radiation Fibrosis Syndrome trials Research Report on Radiation Fibrosis Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Home-Based Photo-Biomodulation for Management of Lymphoedema and Radiation Fibrosis in Patients After Head and Neck Cancer: A Single-Arm Feasibility Trial Riancorp LTU-904 Laser and Handycure® (Medical Quant) - Head and Neck Cancer | Not applicable | Not yet recruiting | Peter MacCallum Cancer Centre, Australia | 30 | 2025-09-04 | 2025-08-24 |
| Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients Photobiomodulation (PBM) Therapy, Sham PBM - Radiation Lymphedema, Radiation Fibrosis | Not applicable | Recruiting | NYU Langone Health | 60 | 2025-02-13 | 2026-03-30 |
| Losartan in Prevention of Radiation-Induced Heart Failure Losartan, Radiation Therapy - Breast Cancer, Myocardial Fibrosis | Early Phase 1 | Completed | Massachusetts General Hospital | 5 | 2023-09-13 | 2026-04-06 |
| Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients Losartan 25 milligram capsule, Placebo - Radiation Induced Fibrosis | Phase 2 | Active not recruiting | Shaw Cancer Center | 43 | 2023-08-17 | 2026-06-18 |
| Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort Radiation therapy protocol for Breast cancer, Spirography and assessment of pulmonary diffusion capacity, Cardiopulmonary stress test - Breast Neoplasms, Radiation Pneumonia | Recruiting | Meshalkin Research Institute of Pathology of Circulation | 200 | 2023-07-18 | 2025-02-11 | |
| Autologous Fat Grafting in Radiated Soft Tissue Reconstruction Breast Cancer, Radiation Fibrosis | Completed | University of Chicago | 10 | 2023-03-01 | 2026-04-23 | |
| Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients Fat grafting - Breast Reconstruction, Radiation Dermatitis | Not applicable | Enrolling by invitation | Mayo Clinic | 15 | 2021-03-01 | 2026-06-01 |
| Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury [68Ga]CBP8 - Lung Cancer, Radiation Fibrosis | Phase 2 | Recruiting | Massachusetts General Hospital | 72 | 2020-07-19 | 2026-02-27 |
| PhysioTouch for Treatment of Radiation Fibrosis Standard OT, PhysioTouch - Radiation Fibrosis | Not applicable | Withdrawn | University of Michigan | 2018-12-01 | 2019-03-06 | |
| Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients Inhaled budesonide - Radiation Pneumonitis | Phase 2 | Recruiting | Instituto Nacional de Cancerologia de Mexico | 72 | 2018-09-01 | 2026-04-08 |
| Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis Endostar, standard SRILI treatment - Radiation Pneumonitis, Endostatin | Phase 2 | Completed | Xinqiao Hospital of Chongqing | 126 | 2018-09-01 | 2024-02-23 |
| Physiotherapy for Radiation-induced Trismus Therabite, Hyperboloid - Trismus, Radiation-induced Fibrosis | Not applicable | Completed | Federal University of Health Science of Porto Alegre | 90 | 2013-06-01 | 2019-01-04 |
| Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology Esophagectomy - Esophageal Cancer, Radiation Pneumonitis | Completed | St. James's Hospital, Ireland | 384 | 2010-01-01 | 2018-03-12 | |
| Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer Losartan - Dyspnea, Lung Cancer | Not applicable | Withdrawn | University of South Florida | 2009-03-01 | 2017-05-02 | |
| Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg Chemotherapy, Radiation therapy, Surgery - Lymphedema, Musculoskeletal Complications | Phase 2 | Completed | Radiation Therapy Oncology Group | 98 | 2008-03-01 | 2019-06-12 |
| Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer hyperbaric oxygen - Breast Cancer, Lymphedema | Phase 2 | Unknown | Institute of Cancer Research, United Kingdom | 63 | 2004-04-01 | 2013-12-18 |
| Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy captopril - Lung Cancer, Pulmonary Complications | Phase 2 | Terminated | Radiation Therapy Oncology Group | 81 | 2003-06-01 | 2018-03-08 |
| IH636 Grape Seed Extract in Treating Hardening of Breast Tissue in Women Who Have Undergone Radiation Therapy for Early Breast Cancer IH636 grape seed proanthocyanidin extract - Breast Cancer, Radiation Fibrosis | Phase 2 | Unknown | Royal Marsden NHS Foundation Trust | 2002-09-01 | 2013-11-06 | |
| Pirfenidone in Treating Patients With Fibrosis Caused by Radiation Therapy for Cancer pirfenidone - Radiation Fibrosis | Not applicable | Completed | National Cancer Institute (NCI) | 2001-10-01 | 2013-06-19 |
Breast Neoplasms (6) · Radiation Pneumonitis (4) · Carcinoma, Non-Small-Cell Lung (3) · Head and Neck Neoplasms (3) · Lung Neoplasms (3) · Lymphedema (3) · Fibrosis (2) · Radiation Injuries (2) · Adenocarcinoma (1) · Camurati-Engelmann Syndrome (1) · Carcinoma, Squamous Cell (1) · Chondrosarcoma, Extraskeletal Myxoid (1) · Dyspnea (1) · Esophageal Neoplasms (1)
Pathologic Processes (19) · Pathological Conditions, Signs and Symptoms (19) · Wounds and Injuries (19) · Fibrosis (17) · Radiation Injuries (17) · Neoplasms (15) · Neoplasms by Site (14) · Respiratory Tract Diseases (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Breast Diseases (6) · Lung Diseases (6) · Lung Diseases, Interstitial (4) · Bronchial Neoplasms (3) · Carcinoma, Bronchogenic (3)
Losartan (3) · Radiotherapy (2) · Captopril (1) · Drug Therapy (1) · Esophagectomy (1) · Exercise Test (1) · Grape Seed Proanthocyanidins (1) · Hyperbaric Oxygenation (1) · Low-Level Light Therapy (1) · Surgical Procedures, Operative (1) · Therapeutics (1) · endostar protein (1) · pirfenidone (1)
Massachusetts General Hospital (2) · Radiation Therapy Oncology Group (2) · Federal University of Health Science of Porto Alegre (1) · Institute of Cancer Research, United Kingdom (1) · Instituto Nacional de Cancerologia de Mexico (1) · Mayo Clinic (1) · Meshalkin Research Institute of Pathology of Circulation (1) · NYU Langone Health (1) · National Cancer Institute (NCI) (1) · Peter MacCallum Cancer Centre, Australia (1) · Royal Marsden NHS Foundation Trust (1) · Shaw Cancer Center (1) · St. James's Hospital, Ireland (1) · University of Chicago (1) · University of Michigan (1)
United States (9) · United Kingdom (2) · Australia (1) · Brazil (1) · Canada (1) · China (1) · Ireland (1) · Mexico (1) · Russia (1)
John R. Yarnold, MD, FRCR (2) · Burton L. Eisenberg, MD (1) · Christin A. Harless, M.D. (1) · David G. Kirsch, MD, PhD (1) · Dian Wang, MD, PhD (1) · Geraldo P. Jotz, Ph.D (1) · John M. Kane, MD (1) · Katie Rogers, MSOTR-CLT (1) · Kenneth Hu (1) · Kevin Camphausen, MD (1) · Marisa Couluris, DO (1) · Michael Lanuti, MD (1) · Oksana Kamenskaya, PhD, MD (1) · Oscar Arrieta, MD MSc (1) · Patricia H Hardenbergh, MD (1)
PMID 17050868, PMID 19962042, PMID 20583979, PMID 23909719, PMID 24459776, PMID 25276362, PMID 25667281, PMID 25808113, PMID 26830686, PMID 28477633, PMID 28596060, PMID 28865520, PMID 36995690, PMID 37808864, PMID 41014160
K08CA259626 (1), R44CA250771 (1)