15 completed, 5 unknown, 4 recruiting, 1 active not recruiting. 27 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 27 | Completed 15, Unknown 5, Recruiting 4, Active not recruiting 1, Not yet recruiting 1, Withdrawn 1 |
Follow Preterm Birth: new trials by email Literature Review of Preterm Birth trials Research Report on Preterm Birth
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-POCUS for Maternal and Neonatal Health in Ethiopia AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China) - Pregnancy, Pregnancy Complications | Phase 4 | Not yet recruiting | Tsinghua University | 1059 | 2025-09-30 | 2025-09-12 |
| Effect of Vaginal Progesterone Treatment on Pregnancy and Newborn Outcomes in Women With Preterm Labor Nifedipine 20 Mg, Dexamethasone, Progesterone 200 mg vaginal capsules - Preterm Labor With Intact Membranes, Preterm Birth | Phase 4 | Completed | Medicare Hospital (Pvt) Limited | 60 | 2025-05-06 | 2026-04-13 |
| Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT) Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg - Preterm Premature Rupture of Membrane, Pregnancy, High Risk | Phase 4 | Recruiting | Ohio State University | 56 | 2024-07-18 | 2026-01-27 |
| Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics Malaria High-Sensitivity Rapid Diagnostic Test (HS-RDT), Artemether-lumefantrine (AL) - Malaria,Falciparum, Malaria in Pregnancy | Phase 4 | Active not recruiting | Duke University | 2174 | 2023-11-06 | 2026-10-30 |
| Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) Celestone + placebo, Celestone + Celestone - Preterm Birth, Premature Birth | Phase 4 | Recruiting | McMaster University | 3254 | 2023-07-20 | 2026-01-07 |
| Prolonged Progesterone to Prevent Preterm Birth From IVF - ET Progesterone Sustained-release vaginal gel - Preterm Birth | Phase 4 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 100 | 2023-04-01 | 2026-06-11 |
| Effect of Banana Blossom on Breast Milk Volume in Mothers of Preterm Newborns Banana Blossom, Placebo - Preterm Birth, Postpartum Women | Phase 4 | Completed | Chulalongkorn University | 70 | 2022-07-13 | 2024-02-07 |
| Comparative Study Between Vaginal Progesterone Alone or Combined With Aspirin in Prevention of Recurrent Preterm Birth Aspirin tablet, Placebo - Preterm Birth | Phase 4 | Completed | Menoufia University | 256 | 2022-04-01 | 2024-01-16 |
| Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial Azithromycin 1 gram IV, Cefazolin and indomethacin - Preterm Birth, Obstetric Labor, Premature | Phase 4 | Unknown | Thomas Jefferson University | 50 | 2021-12-20 | 2023-06-26 |
| Prediction and Prevention of Twin Premature Birth 2021 Progesterone - Preterm Birth | Phase 4 | Unknown | Caixia Liu | 300 | 2021-05-01 | 2021-09-29 |
| Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Placebo oral tablet 500 mg - Low Birthweight, Preterm Birth | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2020-03-01 | 2020-08-17 | |
| Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA Antibiotics, oral Azithromycin and oral Amoxicillin - Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature | Phase 4 | Recruiting | Woman's | 34 | 2019-08-28 | 2021-01-11 |
| Antenatal Azithromycin to Prevent Preterm Birth in Pregnant Women With Vaginal Cerclage Azithromycin Tablets - Preterm Birth | Phase 4 | Completed | Ain Shams Maternity Hospital | 50 | 2019-04-15 | 2020-06-16 |
| Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies Aspirin 100mg - Twin Pregnancy, Preeclampsia | Phase 4 | Unknown | Ministry of Science and Technology of the People´s Republic of China | 425 | 2018-11-01 | 2019-10-29 |
| Atosiban Versus Placebo in the Treatment of Late Threatened Pre-term Birth Atosiban - Preterm Birth | Phase 4 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 760 | 2017-12-01 | 2024-07-25 |
| Feasibility of Vaginal Progesterone to Reduce HIV-Associated Preterm Birth Vaginal Progesterone, Placebo - PreTerm Birth | Phase 4 | Completed | University of North Carolina, Chapel Hill | 140 | 2017-07-01 | 2020-02-06 |
| The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β Zinc, Nifedipine, Beta Carotene - PreTerm Birth | Phase 4 | Completed | Universitas Indonesia | 56 | 2017-01-01 | 2017-11-21 |
| Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Cervical cerclage - Preterm Birth | Phase 4 | Unknown | Federico II University | 587 | 2016-04-01 | 2016-04-21 |
| The Value of Oral Micronized Progesterone in the Prevention of Spontaneous Preterm Birth micronized progesterone, Placebo - Preterm Birth | Phase 4 | Unknown | Ghamra Military Hospital | 212 | 2015-07-01 | 2015-10-09 |
| Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor Nifedipine 20 Mg, Ritodrine Oral Tablet - Preterm Birth | Phase 4 | Completed | Cairo University | 200 | 2015-01-01 | 2019-09-24 |
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Premature Birth (27) · Obstetric Labor, Premature (4) · Pregnancy Complications (3) · Fetal Growth Retardation (2) · Preterm Premature Rupture of the Membranes (2) · Stillbirth (2) · Brain Ischemia (1) · Child Behavior (1) · Chlamydia Infections (1) · Chorioamnionitis (1) · Communicable Diseases (1) · Fetal Death (1) · Fetal Membranes, Premature Rupture (1) · Gonorrhea (1) · Intracranial Hemorrhages (1)
Female Urogenital Diseases and Pregnancy Complications (27) · Urogenital Diseases (27) · Obstetric Labor Complications (26) · Pregnancy Complications (24) · Obstetric Labor, Premature (23) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Female Urogenital Diseases (3) · Fetal Diseases (3) · Genital Diseases (3) · Infections (3) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Death (2)
Azithromycin (4) · Nifedipine (3) · Progesterone (3) · Amoxicillin (2) · Aspirin (2) · Dexamethasone (2) · Anti-Bacterial Agents (1) · Arachidonic Acid (1) · Artemether, Lumefantrine Drug Combination (1) · Betamethasone (1) · Cefazolin (1) · Ceftriaxone (1) · Cerclage, Cervical (1) · Cholecalciferol (1) · Clarithromycin (1)
Maternal-Infantil Vall d´Hebron Hospital (2) · Sarah Keim (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ain Shams Maternity Hospital (1) · Brigham and Women's Hospital (1) · Cairo University (1) · Caixia Liu (1) · Christiana Care Health Services (1) · Chulalongkorn University (1) · Duke University (1) · Federico II University (1) · Ghamra Military Hospital (1) · Glasgow Royal Infirmary (1) · McMaster University (1) · Medicare Hospital (Pvt) Limited (1)
United States (5) · Egypt (4) · China (3) · Spain (2) · Canada (1) · Democratic Republic of the Congo (1) · Ethiopia (1) · France (1) · India (1) · Italy (1) · Kenya (1) · Netherlands (1) · Pakistan (1) · Thailand (1) · United Kingdom (1)
Elena Carreras (2) · Sarah Keim, PhD (2) · Ahmed Abdel-Aziz (1) · Ahmed Maged (1) · Hassan A Bayoumy, MD (1) · Helen Mactier, MD (1) · Jacques Benichou, MD-PhD (1) · Jeffrey Stringer, MD (1) · Jenani S Jayakumaran, MD (1) · Kartik K Venkatesh, MD, PhD (1) · Kellie Murphy, MD,MSc,FRCSC (1) · Maria Goya (1) · Maria M Goya (1) · Marissa Berry, MD (1)
PMID 24837863, PMID 26627728, PMID 28729911, PMID 28941976, PMID 29490101, PMID 30357263, PMID 30579584, PMID 30826339, PMID 31538590, PMID 31984781, PMID 32421208, PMID 33202169, PMID 33768637, PMID 35644107, PMID 35947046, PMID 36453699, PMID 36907997, PMID 41135925
R21HD090987 (1), U01AI162463 (1)