16 completed, 7 unknown, 5 recruiting, 3 terminated. 16 Not applicable, 5 Phase 2, 3 Phase 3, 3 Phase 4, 2 Phase 1.
Follow Chorioamnionitis: new trials by email Literature Review of Chorioamnionitis trials Research Report on Chorioamnionitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers Intrauterine Pressure Catheter, Standard obstetric care at discretion of delivery provider - Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion | Not applicable | Recruiting | Medical College of Wisconsin | 80 | 2026-10-15 | 2026-10-26 |
| Planned Early Induction of Labor vs Expectant Management for PROM Induction of labor with PGE2, Expectant management - Premature Rupture of Membranes (PROM) | Not applicable | Enrolling by invitation | Pakistan Institute of Medical Sciences | 734 | 2026-05-01 | 2026-09-03 |
| IL-6 and Lactates in Cord Blood and Neonatal Outcomes blood sampling - Fetal Infection, Fetal Inflammatory Response Syndrome | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 160 | 2025-10-01 | 2026-09-03 | |
| Preterm Rupture of Membranes Optimising Antibiotics Trial Erythromycin 250mg + placebo, Azithromycin 500mg + placebo, Erythromycin 250mg and Amoxicillin 500mg - PPROM, Preterm | Not applicable | Not yet recruiting | University of Melbourne | 3900 | 2025-09-01 | 2025-04-02 |
| Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT) Acetaminophen, dipyrone - Intrapartum Fever, Chorioamnionitis | Phase 4 | Not yet recruiting | Wolfson Medical Center | 140 | 2025-08-01 | 2025-07-03 |
| Comparing Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Treated With Prophylactic Antibiotics Zinacef vs. Placebo zinacef tretment, Placebo - Meconium-stained Amniotic Fluid, Chorioamnionitis | Not applicable | Recruiting | Western Galilee Hospital-Nahariya | 182 | 2025-02-18 | 2026-09-15 |
| Amniotic Fluid & the Preterm Gut Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn | Recruiting | Maxima Medical Center | 275 | 2024-10-14 | 2025-09-03 | |
| Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT) Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg - Preterm Premature Rupture of Membrane, Pregnancy, High Risk | Phase 4 | Recruiting | Ohio State University | 56 | 2024-07-18 | 2026-01-27 |
| Intrapartum Ultrasound in Labor: Sonography Only, Few Internal Examinations Sonography in labour - Labor Complication | Not applicable | Recruiting | Larry Hinkson | 356 | 2024-02-27 | 2024-02-16 |
| Predictive Value of Maternal Serum Pentraxin 3 (PTX 3) and Heparin-binding Protein (HBP) for Chorioamnionitis in Preterm Premature Rupture of Membranes The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid. - Preterm Premature Rupture of Membrane | Unknown | Second Affiliated Hospital of Wenzhou Medical University | 180 | 2022-02-10 | 2022-01-26 | |
| Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term Cervical examination to assess labor - Chorioamnionitis, Intrauterine Infection | Not applicable | Terminated | Eastern Virginia Medical School | 163 | 2021-09-02 | 2023-08-25 |
| A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator EOS Calculator - Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal | Completed | Pediatrix | 236 | 2020-09-30 | 2022-11-22 | |
| Management of Prelabor Rupture of the Membranes at Term Oxytocin - Fetal Infection, Chorioamnionitis | Not applicable | Unknown | Rambam Health Care Campus | 524 | 2020-05-01 | 2024-04-12 |
| Assessment of Labour Progress by Intrapartum Ultrasound Transperineal Ultrasound - Pregnancy Related, Fever | Not applicable | Completed | Kaplan Medical Center | 180 | 2019-08-27 | 2020-12-03 |
| Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation Sepsis, Necrotizing Enterocolitis | Terminated | Per Torp Sangild | 50 | 2017-09-01 | 2022-03-23 | |
| Selective Use of Antibiotics in Neonates Born to Mothers With Suspected Chorioamnionitis Retrospective Chart Review - Chorioamnionitis | Completed | Pediatrix | 768 | 2017-06-26 | 2025-06-03 | |
| Intrapartum Fever: Antibiotics Versus no Treatment Standard Antibiotic Treatment, No Antibiotic Treatment - Chorioamnionitis, Intrapartum Fever | Phase 4 | Withdrawn | University of Utah | 2017-06-08 | 2018-10-23 | |
| Chorioamnionitis: Observation of at Risk Infants vs Standard Care Clinical observation, Standard management - Chorioamnionitis, Early Onset Neonatal Sepsis | Not applicable | Withdrawn | IRCCS Burlo Garofolo | 2016-10-01 | 2019-07-12 | |
| Effect of Chorioamnionitis on Platelet Activation and Placental Vessel Among Preterm Infants by Wnt-Flt1 Signal Pathway chorioamnionitis - Chorioamnionitis, Placenta Diseases | Completed | Guangdong Women and Children Hospital | 64 | 2016-06-01 | 2018-08-17 | |
| Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes single arm - Preterm Premature Rupture of Membranes, Fetal Inflammatory Response Syndrome | Completed | Martin-Luther-Universität Halle-Wittenberg | 57 | 2016-01-07 | 2018-11-14 |
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Fetal Membranes, Premature Rupture (6) · Neonatal Sepsis (6) · Preterm Premature Rupture of the Membranes (6) · Premature Birth (5) · Endometritis (3) · Fever (2) · Obstetric Labor Complications (2) · Vaginosis, Bacterial (2) · fetal inflammatory response syndrome (2) · Birth Weight (1) · Brain Injuries (1) · Cerebral Palsy (1) · Disease (1) · Enterocolitis, Necrotizing (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (38) · Female Urogenital Diseases and Pregnancy Complications (38) · Fetal Diseases (38) · Pregnancy Complications (38) · Urogenital Diseases (38) · Placenta Diseases (37) · Obstetric Labor Complications (36) · Fetal Membranes, Premature Rupture (32) · Pathological Conditions, Signs and Symptoms (13) · Infections (12) · Pathologic Processes (10) · Inflammation (7) · Systemic Inflammatory Response Syndrome (7) · Genital Diseases (6) · Infant, Newborn, Diseases (6)
Ampicillin (3) · Erythromycin (3) · Gentamicins (3) · Acetylcysteine (2) · Amoxicillin (2) · Azithromycin (2) · Blood Specimen Collection (2) · Metronidazole (2) · Oxytocin (2) · Sodium Chloride (2) · Watchful Waiting (2) · Acetaminophen (1) · Amniocentesis (1) · Cefoxitin (1) · Ceftriaxone (1)
Hospital de Santa Maria, Portugal (2) · Medical University of South Carolina (2) · Ohio State University (2) · Pediatrix (2) · Stanford University (2) · Catholic University of the Sacred Heart (1) · Centers for Disease Control and Prevention (1) · Centre Hospitalier Universitaire Dijon (1) · Eastern Virginia Medical School (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Guangdong Women and Children Hospital (1) · Hadassah Medical Organization (1) · IRCCS Burlo Garofolo (1) · Kaplan Medical Center (1) · Larry Hinkson (1)
United States (15) · Israel (6) · Canada (2) · Germany (2) · Italy (2) · Pakistan (2) · Portugal (2) · China (1) · France (1) · Netherlands (1)
Robert Goldenberg, MD (2) · Boaz Weisz, M.D. (1) · Catalin S Buhimschi, MD, MBA (1) · Clare Whitehead, MBChB, PhD (1) · David Mankuta, MD (1) · Donna Johnson (1) · Dorothea D. Jenkins, MD (1) · Ellen M Giesbrecht, MD (1) · Elvira Di Pasquo (1) · Eugene Chang, MD (1) · Everett F Magann, MD (1) · Filipa Faria Vaz Passos, Dr (1) · Frank Bernhard Kraus, PD; PhD (1) · Gal Bachar, MD (1) · Gregor Seliger, Dr. med (1)
PMID 11181139, PMID 15295368, PMID 16227794, PMID 16522393, PMID 16875654, PMID 17267841, PMID 17978109, PMID 19664210, PMID 20093909, PMID 21251190, PMID 22617572, PMID 23090521, PMID 25064164, PMID 26545726, PMID 26909227, PMID 27658190, PMID 27974410, PMID 28454555, PMID 28742677, PMID 32334543, PMID 35359891, PMID 36396038, PMID 36400420, PMID 36965695, PMID 41602874
R01NS052448 (1), U01HD040607 (1)