10 completed, 4 terminated, 2 unknown, 1 withdrawn. 17 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 10, Terminated 4, Unknown 2, Withdrawn 1 |
| Phase 1 | 5 | Completed 2, Unknown 2, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
Follow Prehypertension: new trials by email Literature Review of Prehypertension trials Research Report on Prehypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Early Hypertension Among Persons Living With HIV in Haiti Amlodipine 5mg - HIV/AIDS, Pre Hypertension | Phase 2 | Completed | Weill Medical College of Cornell University | 250 | 2021-02-26 | 2024-04-09 |
| Safety and Feasibility of Remote Ischemic Conditioning on Prehypertension and Early-stage Hypertension remote ischemic conditioning - Prehypertension, Remote Ischemic Conditioning | Phase 1 / Phase 2 | Unknown | Capital Medical University | 20 | 2019-06-30 | 2020-02-05 |
| Race, Natriuretic Peptides and Physiological Perturbations Exercise capacity VO2 max determination, Standardized meals, Exercise challenge - Healthy, Pre Hypertension | Phase 2 | Completed | University of Alabama at Birmingham | 80 | 2017-04-30 | 2025-03-12 |
| A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure B244, Vehicle - Prehypertension, Hypertension, Stage I | Phase 2 | Completed | AOBiome LLC | 132 | 2016-11-01 | 2022-09-15 |
| A Study to Investigate the Effect of a Nitric Oxide Supplementation on Pre- and Mildly Hypertensive Adults Neo40 Daily®, Placebo - Pre-hypertension | Phase 2 | Terminated | KGK Science Inc. | 67 | 2016-02-03 | 2018-04-12 |
| Center of Research Translation (CORT) Project 2 Allopurinol, Placebo - Pre-hypertension, JNC 7 Stage I Hypertension | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 99 | 2014-07-01 | 2021-01-11 |
| Effect and Safety of Marealis RPC (Refined Peptide Concentrate) in Mild or Moderate Hypertensive Subjects Marealis refined peptide concentrate, Placebo - Prehypertension | Phase 2 | Completed | KGK Science Inc. | 144 | 2013-11-01 | 2015-12-24 |
| Vascular Dysfunction in Human Obesity Hypertension Clonidine, Hydrochlorothiazide, Placebo - Obesity, Prehypertension | Phase 2 | Terminated | Gary L. Pierce | 33 | 2013-10-01 | 2023-04-14 |
| Study of the Effects of an Oral Nitric Oxide Supplement on Blood Pressure in Prehypertensive Adults Nitric Oxide supplement, Placebo - Prehypertension | Phase 1 / Phase 2 | Unknown | Neogenis Laboratories | 30 | 2013-01-01 | 2013-09-10 |
| Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients Menthol, Placebo - Hypertension, Prehypertension | Phase 2 / Phase 3 | Completed | Zhiming Zhu | 36 | 2012-08-01 | 2020-03-11 |
| Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients Potassium, Magnesium, Citrate, Potassium Chloride - Pre-hypertension, Hypertension | Phase 1 / Phase 2 | Withdrawn | University of Texas Southwestern Medical Center | 2009-09-01 | 2019-02-11 | |
| Primary Prevention of Hypertension in Obese Adolescents Allopurinol, Probenecid, Placebo - Obesity, Pre-Hypertension | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 60 | 2008-09-01 | 2017-09-14 |
| Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease carvedilol phosphate, lisinopril, carvedilol phosphate and lisinopril - Pre-hypertension | Phase 1 / Phase 2 | Completed | University of Minnesota | 101 | 2007-11-01 | 2018-04-24 |
| Losartan Versus Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects losartan, hydrochlorothiazide - Pre-hypertension, Pre-diabetes | Phase 2 | Terminated | Sir Mortimer B. Davis - Jewish General Hospital | 1 | 2007-03-01 | 2015-05-19 |
| Telephone-Based Lifestyle Intervention to Reduce Blood Pressure in Prehypertensive Patients Telephone-based lifestyle counseling - High Blood Pressure | Phase 2 | Terminated | NYU Langone Health | 125 | 2007-01-01 | 2013-11-19 |
| Effects of Angeliq and Prempro on Blood Pressure and Sodium Sensitivity in Postmenopausal Women With Prehypertension Drospirenone/17ß-estradiol (Angeliq, BAY86-4891), SH K 00641 C - Medroxyprogesterone acetate / conjugated equine (Prempro TM) - Postmenopause, Hypertension | Phase 2 | Completed | Bayer | 92 | 2007-01-01 | 2015-06-02 |
| The Effect of Hibiscus Sabdariffa L. Tea on Blood Pressure herbal therapy/botanical therapy (Hibiscus sabdariffa) - Hypertension | Phase 1 / Phase 2 | Completed | Tufts University | 66 | 2009-12-03 |
Hypertension (10) · Obesity (2) · Acquired Immunodeficiency Syndrome (1) · Glucose Intolerance (1) · Hyperuricemia (1)
Cardiovascular Diseases (17) · Vascular Diseases (17) · Nutritional and Metabolic Diseases (3) · Body Weight (2) · Nutrition Disorders (2) · Overnutrition (2) · Overweight (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Blood-Borne Infections (1) · Communicable Diseases (1) · Genital Diseases (1) · Glucose Metabolism Disorders (1) · HIV Infections (1) · Hyperglycemia (1)
Allopurinol (2) · Amlodipine (1) · Carvedilol (1) · Clonidine (1) · Hydrochlorothiazide (1) · Lisinopril (1) · Losartan (1) · Menthol (1) · Metoprolol (1) · Phytotherapy (1) · Potassium Chloride (1) · Probenecid (1) · estradiol-drospirenone combination (1) · hydrochlorothiazide, losartan drug combination (1) · potassium-magnesium citrate (1)
KGK Science Inc. (2) · University of Alabama at Birmingham (2) · AOBiome LLC (1) · Bayer (1) · Capital Medical University (1) · Gary L. Pierce (1) · NYU Langone Health (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Neogenis Laboratories (1) · Sir Mortimer B. Davis - Jewish General Hospital (1) · Tufts University (1) · University of Minnesota (1) · University of Texas Southwestern Medical Center (1) · Weill Medical College of Cornell University (1) · Zhiming Zhu (1)
United States (12) · Canada (3) · China (2) · Czechia (1) · Germany (1) · Haiti (1)
Dale Wilson, MD (1) · Daniel I Feig, MD, PhD (1) · Ernesto L. Schiffrin, MD, PhD (1) · Ernst Schwarz, MD, PhD (1) · Gary L Pierce, PhD (1) · Jay N Cohn, MD (1) · Jean Pape (1) · Jeffrey B Blumberg, Ph.D. (1) · Larry Weiss, MD (1) · Margaret McNairy, MD (1) · Matthew M Burg (1) · Pankaj Arora, MD (1) · Tanya M Goyal, PhD (1) · Tetyana Pelipyagina, MD (1)
PMID 11581560, PMID 16476851, PMID 20018807, PMID 21849262, PMID 23006736, PMID 24637663, PMID 31467699, PMID 33779064, PMID 34351939, PMID 34493347, PMID 39761592, PMID 39948072, PMID 9134374, PMID 9357812
K23HL146887 (1), P50AR060772 (1), R21DK071223 (1), R21TW011693 (1)