8 completed, 2 unknown, 1 recruiting. 11 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 8, Unknown 2, Recruiting 1 |
| Phase 2 | 2 | Completed 2 |
Follow Prehypertension: new trials by email Literature Review of Prehypertension trials Research Report on Prehypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity Orforglipron, Placebo - Overweight, Prediabetic State | Phase 3 | Recruiting | Eli Lilly and Company | 2001 | 2026-08-26 | 2026-11-05 |
| Technology for Innovative Monitoring of Cardiovascular Prevention: a RCT TELEM, TELEMEV, TELEM-TELEMEV - Blood Pressure, High, Prehypertension | Phase 3 | Unknown | Hospital de Clinicas de Porto Alegre | 231 | 2017-01-01 | 2018-04-26 |
| Center of Research Translation (CORT) Project 2 Allopurinol, Placebo - Pre-hypertension, JNC 7 Stage I Hypertension | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 99 | 2014-07-01 | 2021-01-11 |
| Impact of Periodontal Intervention on Vascular Dysfunction One-Stage Full-Mouth Disinfection, Periodontal care - Chronic Periodontitis, Prehypertension | Phase 3 | Completed | First Affiliated Hospital, Sun Yat-Sen University | 123 | 2012-12-01 | 2015-04-17 |
| Effects and Safety of Taurine Granule on Blood Pressure in Prehypertensive Taurine granule, Placebo - Prehypertension | Phase 3 | Completed | Zhiming Zhu | 120 | 2012-12-01 | 2015-11-24 |
| Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients Menthol, Placebo - Hypertension, Prehypertension | Phase 2 / Phase 3 | Completed | Zhiming Zhu | 36 | 2012-08-01 | 2020-03-11 |
| The Effects of Polyphenol-rich Berry Juice on Blood Pressure in Hypertensive Subjects Placebo, Mana-juice, Optijuice - Pre-hypertension, Hypertension | Phase 3 | Completed | University of Oslo | 153 | 2011-12-01 | 2012-07-03 |
| Blood Pressure Lowering Effect of Supplementation With Korea Red Ginseng Associated With Reductions in Circulating Lp-PLA2 Activity and Lysophospatidylcholines and an Increase in Dihydrobiopterin in Prehypertensive Subjects KRG, Placebo - Prehypertension | Phase 3 | Completed | Yonsei University | 62 | 2011-11-01 | 2014-12-29 |
| Effect of Ginseol Kg1 on Blood Pressure Lowering Ginseol Kg1 (low dose), Ginseol Kg1(high dose), Placebo - Prehypertension, Hypertension, Stage I | Phase 3 | Unknown | Seoul National University Hospital | 90 | 2011-09-01 | 2011-12-02 |
| Hypertension Prevention in Pre-Hypertensive Individuals Chlorthalidone plus amiloride, placebo - Pre-hypertension, Hypertension | Phase 3 | Completed | Hospital de Clinicas de Porto Alegre | 730 | 2010-07-01 | 2015-02-12 |
| Salt Reduction on Blood Pressure and Cardiovascular Organ Damage Reduce salt intake - Hypertension | Phase 3 | Completed | St George's, University of London | 210 | 2004-04-01 | 2015-06-09 |
Hypertension (7) · Cardiovascular Diseases (1) · Chronic Periodontitis (1) · Obesity, Abdominal (1) · Overweight (1) · Periodontitis (1) · Prediabetic State (1)
Vascular Diseases (11) · Cardiovascular Diseases (10) · Pathological Conditions, Signs and Symptoms (2) · Body Weight (1) · Chronic Disease (1) · Diabetes Mellitus (1) · Disease Attributes (1) · Endocrine System Diseases (1) · Glucose Metabolism Disorders (1) · Metabolic Diseases (1) · Mouth Diseases (1) · Nutrition Disorders (1) · Nutritional and Metabolic Diseases (1) · Obesity (1) · Overnutrition (1)
Allopurinol (1) · Amiloride (1) · Chlorthalidone (1) · Diuretics (1) · Menthol (1) · orforglipron (1)
Hospital de Clinicas de Porto Alegre (2) · Zhiming Zhu (2) · Eli Lilly and Company (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Seoul National University Hospital (1) · St George's, University of London (1) · University of Alabama at Birmingham (1) · University of Oslo (1) · Yonsei University (1)
China (4) · Brazil (2) · South Korea (2) · United States (2) · Argentina (1) · Czechia (1) · Germany (1) · India (1) · Japan (1) · Mexico (1) · Norway (1) · Puerto Rico (1) · Spain (1) · Taiwan (1) · United Kingdom (1)
Graham A MacGregor, MD (1) · Jun Tao, M.D.,phD. (1) · Jun Ying Yang, Master (1) · Kwang-il Kim, MD, PhD (1) · Rune Blomhoff, PhD (1) · Sandra C Fuchs (1) · Sandra C Fuchs, MD, PhD (1)
PMID 24637663, PMID 24871654, PMID 26843120, PMID 27965209, PMID 28452620, PMID 29227377, PMID 30087093, PMID 31079530, PMID 32475312, PMID 33779064, PMID 34493347, PMID 37107903
P50AR060772 (1)