283 completed, 80 unknown, 46 terminated, 36 recruiting. 507 Phase 3, 112 Phase 2.
Follow Pregnancy Complications: new trials by email Literature Review of Pregnancy Complications trials Research Report on Pregnancy Complications
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus Semaglutide (Wegovy) weekly injection - Gestational Diabetes Mellitus (GDM), Metabolic Syndrome | Phase 2 / Phase 3 | Not yet recruiting | University of Massachusetts, Worcester | 226 | 2027-09-01 | 2026-09-28 |
| Optimal Time Interval Between Mifepristone and Misoprostol Administration for Early Pregnancy Loss 200mg mifepristone and 800mg misoprostol - Early Pregnancy Loss | Phase 3 | Not yet recruiting | University of Pennsylvania | 1000 | 2027-07-01 | 2026-10-09 |
| Periodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based Trial A package of oral health interventions, including a daily antiseptic oral rinse (alcohol-free cetylpyridinium chloride (0.075%)) - Preterm Birth, Low Birth Weight | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 2280 | 2026-12-31 | 2026-10-30 |
| Efficacy of Progesterone and Low Molecular Weight Heparin in Recurrent Pregnancy Loss Vaginal Micronized Progesterone (Progesterone Besins), Enoxaparin (Clexane) - Pregnancy Loss, Pregnancy Loss, Early | Phase 3 | Not yet recruiting | General University Hospital, Prague | 268 | 2026-12-01 | 2026-10-28 |
| AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm Birth Vaginal flora abnormalities screening and quantification using molecular biology technique, Azithromycin, Ceftriaxone - Bacterial Vaginosis, Vaginal Dysbiosis | Phase 3 | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 1794 | 2026-10-01 | 2026-08-27 |
| Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg - Hypertension in Pregnancy, Obstetrical Complications | Phase 3 | Not yet recruiting | The George Washington University Biostatistics Center | 4120 | 2026-09-30 | 2026-09-18 |
| A Combination of Antibiotics to Decrease Neonatal Morbidity and Mortality for Previable Threatened Labor Combination of antibiotics, Emergency cerclage, Vaginal progesterone - Previable Labour With Intact Membranes | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 350 | 2026-09-01 | 2026-05-01 |
| Brexanolone Lifting Outcomes Of Moms LPCN 1154A, Placebo - Depression, Postpartum, Postpartum Depression (PPD) | Phase 3 | Recruiting | Lipocine Inc. | 120 | 2026-09-01 | 2026-09-16 |
| Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants Nicotinamide Riboside (NR), Placebo - Preterm Birth, Inadequate Milk Production | Phase 2 / Phase 3 | Recruiting | University of California, Davis | 40 | 2026-08-19 | 2026-09-14 |
| A Study of MI078 for Postpartum Depression MI078 capsule, Placebo of MI078 capsules - Postpartum Depression (PPD) | Phase 3 | Recruiting | Nanjing Minova Pharmaceutical Co., Ltd. | 200 | 2026-07-10 | 2026-07-23 |
| Optimizing the Use of Aspirin for the Prevention of Preeclampsia Discontinuation of Acetylsalicilic acid 150 mg/day at 24-28 weeks of gestation - Preeclampsia | Phase 3 | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 15160 | 2026-07-01 | 2026-06-24 |
| Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation Dexmedetomidine (IV) 0.5 mcg/kg, Placebo - Abortion, Stillbirth | Phase 2 / Phase 3 | Withdrawn | Stanford University | 2026-07-01 | 2026-07-17 | |
| The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity Aspirin, Low-molecular-weight heparin - Venous Thromboembolism, Postpartum Period | Phase 3 | Recruiting | University of Calgary | 8805 | 2026-06-04 | 2026-07-27 |
| Antenatal Magnesium Sulphate in High-Risk Preterm Patients Magnesium sulfate, Placebo - Cerebral Palsy, Magnesium Sulfate Overdose | Phase 3 | Recruiting | Cairo University | 138 | 2026-05-01 | 2026-04-13 |
| Investigating the Efficacy of Tranexamic Acid as a Prophylactic Agent in Reducing Postpartum Hemorrhage Among Patients Undergoing Cesarean Section in SQUH tranexamic acid (1 g diluted in 100 mL of 0.9% saline, Normal (0.9%) saline - Post Partum Haemorrhage | Phase 3 | Not yet recruiting | Sultan Qaboos University | 88 | 2026-05-01 | 2026-04-01 |
| Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Xylitol Chewing gum, Sorbitol chewing gum - Preterm Birth, Low Birthweight Neonate | Phase 2 / Phase 3 | Recruiting | University of Washington | 6000 | 2026-03-26 | 2026-09-10 |
| Tranexamic Acid vs Vasopressin in Placenta Previa Trial Group A: Tranexamic acid, Group B: Vasopressin - Placenta Previa | Phase 3 | Not yet recruiting | Allama Iqbal Medical College | 58 | 2026-03-01 | 2026-02-20 |
| Dexamethasone Regimens for BPD Prevention in Preterm Infants Dexamethasone. Dart, Dexametasone. Medium - Infant, Premature, Bronchopulmonary Dysplasia (BPD) | Phase 3 | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 970 | 2026-02-01 | 2025-11-24 |
| EVE TRIAL , ALMA SYSTAM Alma System - Postpartum Haemorrhage (PPH), PPH | Phase 3 | Recruiting | ResQ Medical Ltd | 50 | 2026-01-11 | 2026-03-30 |
| Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure Levetiracetam, magnesium sulfate - Severe Preeclampsia, Eclampsia Preeclampsia | Phase 3 | Not yet recruiting | Nebraska Methodist Health System | 1240 | 2026-01-01 | 2025-10-24 |
Showing 20 of 507. Sign in to see all of them.
Premature Birth (180) · Pre-Eclampsia (61) · Postpartum Hemorrhage (52) · Diabetes, Gestational (31) · Fetal Growth Retardation (25) · Bronchopulmonary Dysplasia (21) · Depression, Postpartum (21) · Obstetric Labor, Premature (19) · Respiratory Distress Syndrome (18) · Abortion, Spontaneous (17) · Hypertension, Pregnancy-Induced (16) · Abortion, Habitual (14) · HIV Infections (11) · Perinatal Death (10)
Female Urogenital Diseases and Pregnancy Complications (507) · Urogenital Diseases (507) · Obstetric Labor Complications (268) · Obstetric Labor, Premature (170) · Pathological Conditions, Signs and Symptoms (166) · Pathologic Processes (122) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (89) · Puerperal Disorders (76) · Hypertension, Pregnancy-Induced (53) · Uterine Hemorrhage (52) · Hemorrhage (51) · Nutritional and Metabolic Diseases (50) · Signs and Symptoms (50) · Respiratory Tract Diseases (46)
Misoprostol (26) · Metformin (21) · Tranexamic Acid (21) · Sodium Chloride (20) · Aspirin (17) · Oxytocin (17) · Progesterone (16) · Saline Solution (13) · Nifedipine (12) · Insulin (10) · Methotrexate (10) · Utrogestan (8) · Sildenafil Citrate (7) · carbetocin (7) · 17 alpha-Hydroxyprogesterone Caproate (6)
Ain Shams University (20) · NICHD Neonatal Research Network (19) · The George Washington University Biostatistics Center (11) · Assiut University (9) · Assistance Publique - Hôpitaux de Paris (8) · Cairo University (8) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Federico II University (6) · Benha University (5) · Saint Thomas Hospital, Panama (5) · Stanford University (5) · University of Pennsylvania (5) · GlaxoSmithKline (4) · Gynuity Health Projects (4) · Hadassah Medical Organization (4)
United States (155) · Egypt (48) · France (36) · Canada (34) · Italy (27) · Spain (26) · China (20) · Israel (20) · United Kingdom (20) · Germany (13) · Belgium (12) · Netherlands (12) · Brazil (11) · India (10) · Denmark (8)
Seetha Shankaran, MD (16) · Barbara J. Stoll, MD (11) · Richard A. Ehrenkranz, MD (11) · Edward F. Donovan, MD (10) · Sheldon B. Korones, MD (10) · Avroy A. Fanaroff, MD (9) · David K. Stevenson, MD (8) · Jon E. Tyson, MD MPH (8) · Charles R. Bauer, MD (7) · James A. Lemons, MD (7) · Lu-Ann Papile, MD (7) · Waldemar A. Carlo, MD (7) · William Oh, MD (7) · Abbot R. Laptook, MD (5) · Abhik Das, PhD (5)
PMID 35947046, PMID 36996264, PMID 33006765, PMID 33232518, PMID 39162220, PMID 20008425, PMID 29282009, PMID 30177236, PMID 33181049, PMID 33779986, PMID 10400143, PMID 10485720, PMID 10545589, PMID 10625862, PMID 10654946, PMID 10802492, PMID 11150359, PMID 11207490, PMID 11416871, PMID 11430325, PMID 11509999, PMID 11581447, PMID 11600822, PMID 12114906, PMID 12219057, PMID 12439209, PMID 12502678, PMID 12600870, PMID 12622582, PMID 13678973, PMID 14510322, PMID 14722443, PMID 14993550, PMID 15121931, PMID 15213559, PMID 15242535, PMID 15507947, PMID 15520109, PMID 15713717, PMID 15733401, PMID 16000352, PMID 16123677, PMID 16220994, PMID 16227794, PMID 16284468, PMID 16356432, PMID 16511414, PMID 16522393, PMID 16615955, PMID 16647401
U10HD021385 (17), U10HD027853 (15), U10HD027880 (15), U10HD021373 (14), U10HD027851 (14), U10HD027856 (14), U10HD027904 (14), U10HD021364 (13), U10HD027871 (12), U10HD021397 (11), U10HD034216 (11), M01RR000070 (10), M01RR000750 (10), M01RR008084 (10), U10HD021415 (10)