24 completed, 10 unknown, 8 not yet recruiting, 6 recruiting. 23 Not applicable, 9 Phase 4, 7 Phase 3, 2 Phase 2.
Follow PONV: new trials by email Literature Review of PONV trials Research Report on PONV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Amisulpride Injection for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery Amisulpride, Ondansetron - PONV | Not applicable | Not yet recruiting | Qianfoshan Hospital | 718 | 2026-11-15 | 2026-10-23 |
| Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection. Opioid Free Anaesthesia, conventential opioid-based anaesthesia (OBA, - PONV | Not applicable | Not yet recruiting | Sohag University | 120 | 2026-09-01 | 2026-09-08 |
| Risk Factors for Postoperative Nausea and Vomiting After Nasal Surgery Under General Anesthesia PONV | Not yet recruiting | Eye & ENT Hospital of Fudan University | 1000 | 2026-08-01 | 2026-08-06 | |
| Aprepitant to Improve Same Day Discharge for TKA Aprepitant Injection, Ondansetron (Zofran), Dexamethasone - PONV | Phase 4 | Not yet recruiting | Endeavor Health | 350 | 2026-07-01 | 2026-06-10 |
| Effect of Lidocaine Through Gastric Tube on PONV Lidocaine, Normal Saline (0.9% NaCl) - PONV | Not applicable | Recruiting | General Hospital of Ningxia Medical University | 100 | 2026-05-20 | 2026-06-11 |
| Amisulpride for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery Tropisetron - PONV | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 526 | 2026-05-10 | 2026-04-28 | |
| Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung Cancer Surgery Prophylactic administration of dolasetron, Electroacupuncture, Sham electroacupuncture - PONV | Not applicable | Recruiting | Shanghai Chest Hospital | 204 | 2026-04-07 | 2026-04-13 |
| Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery Saline (0.9% NaCl), TAP Block, moderate dose Dexamethasone - Postoperative Recovery, PONV | Not applicable | Not yet recruiting | Ankara City Hospital Bilkent | 135 | 2026-03-30 | 2026-03-13 |
| Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery Oliceridine, Sufentanil - PONV, Cerebellopontine Angle Tumor | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 174 | 2026-03-25 | 2026-05-22 |
| Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery Target Controlled Infusion, Total Intravenous Anesthesia(TIVA) - Postoperative Delirium (POD), Postoperative Pain | Not applicable | Completed | Istanbul University - Cerrahpasa | 63 | 2026-01-14 | 2026-09-09 |
| Effectiveness of Unilateral Transversus Abdominis Plane (TAP) Block vs Bilateral TAP Block in Patients Undergoing Laparoscopic Cholecystectomy. Unilateral Transversus abdominis plane (TAP) block with 0.25 % bupivacaine, Bilateral Transversus abdominis plane (TAP) block with 0.25 % bupivacaine - Post Operative Pain Control, PONV | Not applicable | Enrolling by invitation | King Edward Medical University | 82 | 2025-11-04 | 2026-04-06 |
| Effect of BIS-Guided Anesthesia on Postoperative Nausea and Vomiting in Pediatric Patients BIS GROUP, CONTROL GROUP - PONV, BIS | Not applicable | Completed | Engin Çetin | 58 | 2025-09-24 | 2026-02-12 |
| Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline - Obese Patients, Bariatric Surgical Pain | Not applicable | Not yet recruiting | IVO JURISIC | 36 | 2025-07-30 | 2025-07-24 |
| Sugammadex Reduces Antiemetic Effect of Dexamethasone PONV | Not yet recruiting | Augusta University | 100 | 2025-04-01 | 2025-03-30 | |
| A Comparison of the Efficacy of Amisulpride and Placebo in the Prevention of PONV in Patients at Moderate-to-high Risk of PONV. Amisulpride, Amisulpride Placebo - PONV | Phase 3 | Unknown | Qilu Pharmaceutical (Hainan) Co., Ltd. | 516 | 2023-04-29 | 2023-04-21 |
| Aromatherapy Treatment With Lavender Essential Oil to Reduce Post-Operative Nausea and Vomiting (PONV) Lavanda Angustifolia essential oil, Usual Care - PONV | Not applicable | Active not recruiting | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria | 128 | 2022-11-15 | 2025-09-16 |
| Dual-chamber Patient-controlled Analgesia for Postoperative Recovery multimodal analgesia via dual-chamber PCA, single regimen (only fentanyl) - Morbid Obesity, PCA | Not applicable | Recruiting | Seoul National University Bundang Hospital | 92 | 2022-10-11 | 2025-07-03 |
| Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting Minimizing blood pressure variability - PONV, Blood Pressure | Not applicable | Unknown | Medical University of Vienna | 272 | 2022-10-01 | 2023-07-11 |
| Comparison of Dexamethasone Alone vs in Combination With Pericardium 6 (P6) Electrical Stimulation or Granisetron in the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Breast Cancer Surgery electric stimulation therapy - Mammary Cancer, PONV | Not applicable | Completed | Fudan University | 198 | 2022-06-10 | 2023-09-26 |
| Acupoint Stimulation Alleviates Postoperative Nausea and Vomiting transcutaneous electrical acupoint stimulation - PONV | Not applicable | Unknown | Zhihong LU | 158 | 2022-05-30 | 2022-05-31 |
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Postoperative Nausea and Vomiting (50) · Pain, Postoperative (6) · Nausea (4) · Pain (4) · Vomiting (4) · Postoperative Complications (2) · Agnosia (1) · Breast Neoplasms (1) · Delayed Emergence from Anesthesia (1) · Emergence Delirium (1) · Fatigue (1) · Gallbladder Diseases (1) · Hemorrhage (1) · Neuroma, Acoustic (1) · Obesity, Morbid (1)
Pathologic Processes (50) · Pathological Conditions, Signs and Symptoms (50) · Signs and Symptoms (50) · Signs and Symptoms, Digestive (50) · Postoperative Complications (48) · Nausea (46) · Vomiting (46) · Neurologic Manifestations (10) · Pain (5) · Nervous System Diseases (4) · Cranial Nerve Diseases (2) · Neoplasms (2) · Neoplasms by Site (2) · Neurobehavioral Manifestations (2) · Biliary Tract Diseases (1)
Dexamethasone (8) · Saline Solution (5) · Amisulpride (4) · Ondansetron (4) · Palonosetron (4) · Dexmedetomidine (3) · Lidocaine (3) · Ketamine (2) · Sodium Chloride (2) · Sufentanil (2) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · Acupuncture Therapy (1) · Aprepitant (1) · Bupivacaine (1) · Calcium Dobesilate (1)
Acacia Pharma Ltd (3) · Umeå University (2) · Yonsei University (2) · Ajou University School of Medicine (1) · Ankara City Hospital Bilkent (1) · Augusta University (1) · Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria (1) · Basak Ceyda MECO (1) · Campus Bio-Medico University (1) · Cathay General Hospital (1) · Coombe Women and Infants University Hospital (1) · Endeavor Health (1) · Engin Çetin (1) · Eye & ENT Hospital of Fudan University (1) · Fudan University (1)
United States (7) · China (5) · South Korea (5) · Turkey (Türkiye) (5) · Sweden (3) · Brazil (2) · Egypt (2) · France (2) · Germany (2) · Italy (2) · Taiwan (2) · Austria (1) · Croatia (1) · Denmark (1) · Ireland (1)
Ali Okuyan, MD (1) · Aneeqah Din Muhammad, MBBS, MSurg (1) · Christian Reiterer, MD (1) · Chuen-shin Jeng, MD, MS (1) · Dae Hee Kim, MD (1) · Dorothy Turitwenka (1) · Eckhard Mauermann, MD, MSc (1) · Fabricio T Mendonca, MD, TSA (1) · Farah Nasuha Mohd Daut (1) · Jakob Wallden, MD PhD (1) · Jeanna Blitz, MD (1) · Jiacheng Sun, M.M. (1) · Jun Zhang, PhD (1)
PMID 21519222, PMID 26032041, PMID 26258655, PMID 31567573, PMID 3354872, PMID 33581727, PMID 34002866, PMID 36404985, PMID 39303649, PMID 42003699, PMID 42690324