50 completed, 21 recruiting, 21 unknown, 9 terminated. 44 Not applicable, 31 Phase 2, 9 Phase 1, 5 Phase 3, 4 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of ChatGPT in Vestibular Schwannoma Management Use of chatGPT for 1 week - Vestibular Schwannoma | Not applicable | Withdrawn | University of Southern California | 2027-01-01 | 2026-01-13 | |
| Selumetinib for NF2-Related Schwannomatosis Selumetinib - Neurofibromatosis Type 2, NF2 | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 20 | 2026-12-01 | 2026-10-28 |
| Luvometinib in Combination With Serplulimab for NF2-Related Tumors Luvometinib, Serplulimab - NF2-related Schwannomatosis, NF2 | Phase 1 / Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 30 | 2026-07-31 | 2026-07-16 |
| Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2) Selumetinib 25mg/m2, Luvometinib, Serplulimab - Neurofibromatosis Type 2, Vestibular Schwannoma | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 200 | 2026-07-18 | 2026-07-20 |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| Study to Determine Optimal Dose, Evaluate the Efficacy and Safety of PRG-N-01 in Patients With Neurofibromatosis Type II Trineumin - Neurofibromatosis Type II, NF2 | Phase 1 / Phase 2 | Not yet recruiting | PRG Science & Technology Co., Ltd. | 25 | 2026-07-01 | 2026-01-23 |
| Measuring Vestibular Organ Function With Weak Alternating Current Stimulation Active transcranial electrical vestibular stimulation (Active EVS), Sham transcranial electrical vestibular stimulation (Sham EVS), Control measurement - Vestibular Disorder, Vestibular Schwannoma | Not applicable | Enrolling by invitation | Aalto University | 30 | 2026-06-08 | 2026-07-01 |
| Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery Oliceridine, Sufentanil - PONV, Cerebellopontine Angle Tumor | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 174 | 2026-03-25 | 2026-05-22 |
| Long Term Follow-up Study of AAVAnc80-antiVEGF Gene Therapy Vestibular Schwannoma | Enrolling by invitation | Akouos, Inc. | 100 | 2026-03-02 | 2026-07-16 | |
| Assessment of Patient Experience With Auto-Captioning Glasses in NF2-Related-Schwannomatosis Auto-captioning Glasses - NF2-related Schwannomatosis | Not applicable | Completed | Massachusetts General Hospital | 18 | 2026-02-19 | 2026-08-25 |
| Steroids for Facial Nerve Function Protection in Post-surgical Vestibular Schwannoma Patients Steroids therapy, Placebo - Vestibular Schwannoma, Facial Nerve Paralysis | Phase 3 | Recruiting | Beijing Tiantan Hospital | 364 | 2025-10-09 | 2026-10-26 |
| 3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features Vestibular Schwannoma | Recruiting | Shengjing Hospital | 30 | 2025-09-25 | 2026-10-16 | |
| Vestibular Rehabilitation Protocol in Unilateral Vestibular Schwannoma No Intervention: Observational Cohort, Structured home-based vestibular telerehabilitation program, CE-marked clinical rotatory chair - Vestibular Schwannoma, Vestibular Schwannomas | Not applicable | Recruiting | Albert Torrents Torrero | 75 | 2025-09-01 | 2026-01-23 |
| Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma vestibular schwannoma resection - Vestibular Schwannoma, Unilateral Vestibular Deficit | Not applicable | Recruiting | Marketa Bonaventurova | 40 | 2025-06-01 | 2026-10-22 |
| Early Rehabilitation Using Head Impulse Test for Acute Vestibular Deficit Experimental treatment: Head movements, Sham treatment: only eye movements - Vestibular Schwannoma, Unilateral Vestibular Deficit | Not applicable | Recruiting | Hospices Civils de Lyon | 26 | 2025-05-13 | 2025-05-16 |
| Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma AAVAnc80-antiVEGF via Akouos Delivery Device - Vestibular Schwannoma | Phase 1 / Phase 2 | Recruiting | Akouos, Inc. | 27 | 2025-01-17 | 2026-04-06 |
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| USPIO Enhanced MR Imaging in CNS Tumours (UMIC) USPIO enhanced MRI - Vestibular Schwannoma, Glioma, Astrocytic | Not applicable | Recruiting | Northern Care Alliance NHS Foundation Trust | 17 | 2024-04-26 | 2024-08-27 |
| Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife Radio-surgery Vestibular exam - Vestibular Schwannoma, Neurinoma, Acoustic | Not applicable | Unknown | Centre Hospitalier Universitaire de Besancon | 20 | 2024-02-20 | 2024-09-19 |
| Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas Microsurgical resection of VS, Stereotactic radiosurgery, PREHAB - Vestibular Schwannoma | Not applicable | Recruiting | Medical College of Wisconsin | 36 | 2024-01-22 | 2026-03-24 |
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Neurofibromatosis 2 (47) · Meningioma (18) · Brain Neoplasms (10) · Ependymoma (10) · Neurilemmoma (8) · Neurofibromatoses (8) · Hearing Loss (7) · Neurofibromatosis 1 (7) · Vestibular Diseases (7) · Glioma (5) · Astrocytoma (4) · Dizziness (4) · Glioblastoma (4) · Neoplasms (4)
Cranial Nerve Diseases (122) · Cranial Nerve Neoplasms (122) · Ear Diseases (122) · Neoplasms by Histologic Type (122) · Neoplasms, Nerve Tissue (122) · Nerve Sheath Neoplasms (122) · Neuroectodermal Tumors (122) · Neuroendocrine Tumors (122) · Otorhinolaryngologic Neoplasms (122) · Neoplasms, Germ Cell and Embryonal (121) · Nervous System Diseases (121) · Neuroma (121) · Retrocochlear Diseases (121) · Otorhinolaryngologic Diseases (120) · Vestibulocochlear Nerve Diseases (120)
Bevacizumab (7) · Radiosurgery (6) · Cochlear Implants (4) · Everolimus (4) · AZD 6244 (3) · Gentamicins (3) · HDAC-42 (2) · Lapatinib (2) · Sirolimus (2) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · 89Zr-bevacizumab (1) · Aspirin (1) · Axitinib (1)
Massachusetts Eye and Ear Infirmary (6) · Massachusetts General Hospital (6) · Beijing Tiantan Hospital (5) · NYU Langone Health (5) · Medical University of Vienna (3) · University Hospital Tuebingen (3) · Akouos, Inc. (2) · Assistance Publique - Hôpitaux de Paris (2) · Assistance Publique Hopitaux De Marseille (2) · Central Hospital, Nancy, France (2) · Christoph Arnoldner (2) · FDA Office of Orphan Products Development (2) · Haukeland University Hospital (2) · Henry Ford Health System (2) · Lund University (2)
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Ana-Maria Vranceanu, PhD (3) · Matthias A Karajannis, MD, MS (3) · Aaron Tward, MD (2) · D. Bradley Welling, MD, PhD (2) · Fu Zhao (2) · Matthew L Carlson, MD (2) · Pinan Liu (2) · Scott Plotkin, MD (2) · Theodore Nicolaides, MD (2) · Anhua Wu, MD (1) · Antonio Omuro (1) · Ashkan Monfared, MD (1) · Brad Welling, MD, PhD (1)
PMID 17917842, PMID 19574236, PMID 19645909, PMID 22027076, PMID 10449559, PMID 11587600, PMID 11710496, PMID 11981398, PMID 12925338, PMID 12943357, PMID 14724495, PMID 15354006, PMID 15519876, PMID 17438254, PMID 17562049, PMID 18607963, PMID 18769654, PMID 19645932, PMID 20592851, PMID 20592852, PMID 20802221, PMID 20851113, PMID 23573135, PMID 24904885, PMID 25745609, PMID 26247776, PMID 26943915, PMID 26976425, PMID 28053986, PMID 28811848, PMID 30355560, PMID 30666464, PMID 31083225, PMID 31511780, PMID 31796939, PMID 32421171, PMID 33737417, PMID 34409538, PMID 34570301, PMID 34667843, PMID 35064449, PMID 35229827, PMID 35925531, PMID 36240730, PMID 36651958, PMID 36809199, PMID 37311055, PMID 37378983, PMID 37440099, PMID 37526718
2017 (1), P30CA006973 (1), P30CA008748 (1), P30CA086862 (1), R01DC003196 (1), R01DC012593 (1), R01DC017425 (1), R44CA261240 (1), U01CA069856 (1)