97 completed, 15 terminated, 14 unknown, 12 recruiting. 34 Phase 2, 30 Phase 3, 28 Not applicable, 25 Phase 4, 17 Phase 1.
Follow Niacin: new trials by email Literature Review of Niacin trials Research Report on Niacin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain Psilocybin 10 mg, Psilocybin 25 mg, Niacin 100 mg - Chronic Low Back Pain (CLBP), Physical Therapy | Phase 2 | Not yet recruiting | Yale University | 48 | 2026-12-01 | 2026-10-26 |
| Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS) Psilocybin 25 mg, Psychotherapy Treatment Session, Niacin 100 mg - IBS - Irritable Bowel Syndrome | Early Phase 1 | Not yet recruiting | NYU Langone Health | 10 | 2026-08-01 | 2026-03-05 |
| Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver. Niacin (250mg), Placebo Oral Tablet - Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH | Not applicable | Recruiting | Université de Sherbrooke | 36 | 2026-06-22 | 2026-07-02 |
| Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin. Psilocybin (Usona Institute), Niacin 100 mg - Healthy Adults | Early Phase 1 | Recruiting | Pontifícia Universidade Católica do Rio de Janeiro | 100 | 2026-04-01 | 2026-07-28 |
| Clinical Trial on the Protective Role of Vitamin B3 in Enhancing Immunotherapy for Bladder Cancer Patients Tislelizumab, Cisplatin, Gemcitabine and Vitamin B3 - Bladder (Urothelial, Transitional Cell) Cancer | Phase 1 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 12 | 2025-08-01 | 2026-06-30 |
| Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide - Glaucoma | Phase 2 | Recruiting | Christopher Kai Shun Leung | 138 | 2025-05-19 | 2025-06-26 |
| Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia Atorvastatin, Simvastatin, Rozuvastatin - Atherosclerotic Cardiovascular Disease | Recruiting | Novartis Pharmaceuticals | 2382 | 2025-04-15 | 2025-08-03 | |
| Psilocybin-assisted Therapy for Alcohol Use Disorder Psilocybin, Niacin - Alcohol Use Disorder, Alcohol Dependence | Phase 2 | Unknown | University of Sydney | 90 | 2024-09-01 | 2024-06-10 |
| The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD. MDMA, Niacin - Post Traumatic Stress Disorder | Phase 1 | Withdrawn | Yale University | 2024-05-01 | 2026-05-19 | |
| Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy Psilocybin, Niacin - Depression, Anxiety, Psilocybin-Assisted Psychotherapy | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 48 | 2024-04-16 | 2026-11-03 |
| Study the Effect of Niacin on Lipoprotein (a) Concentration and Hyperphosphatemia in Hemodialysis Patients Niacin tablets 500 mg - End-stage Renal Disease | Phase 2 / Phase 3 | Unknown | Al-Azhar University | 50 | 2024-03-15 | 2025-01-31 |
| A Study of Niacin Regulation Niacin - Excessive Weight Gain | Early Phase 1 | Recruiting | Mayo Clinic | 32 | 2024-01-01 | 2026-04-13 |
| Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery Bariatric surgery, Nicotinic Acid - Diabetes Mellitus Type 2 | Not applicable | Recruiting | Université de Sherbrooke | 40 | 2023-11-01 | 2026-02-10 |
| 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder Psilocybin, Niacin - Tobacco Use Disorder | Phase 2 | Recruiting | Johns Hopkins University | 66 | 2023-11-01 | 2026-06-29 |
| MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder Prolonged exposure therapy, MDMA, Niacin - PTSD, Alcohol Use Disorder | Phase 2 | Unknown | University of Sydney | 120 | 2023-09-19 | 2023-11-07 |
| Psilocybin Therapy in Advanced Cancer Psilocybin 25 mgs, Niacin 100mg, Psychotherapy - Advanced Cancer | Phase 2 / Phase 3 | Recruiting | NYU Langone Health | 200 | 2023-05-24 | 2026-10-14 |
| Pilot Trial of Supplemental Vitamin A and Nicotinamide Vitamin A, Nicotinamide, Other: Placebo - Skin Cancer, Kidney Transplant Recipients | Early Phase 1 | Recruiting | Rhode Island Hospital | 30 | 2023-04-01 | 2026-03-20 |
| Effect of Nicotinic Acid as Add on Therapy in Patients Receiving β Blocker for Prophylaxis of Moderate to Severe Migraine Nicotinic Acid 500 MG Extended Release Oral Tablet, Nicotinic Acid 1000 MG Extended Release Oral Tablet, Placebo - Migraine Prophylaxis | Phase 2 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 58 | 2022-11-25 | 2025-11-18 |
| Glycogen and Appetite Exercise plus carbohydrate, Exercise plus niacin, Placebo - Energy Intake | Not applicable | Completed | University of Bath | 15 | 2022-10-10 | 2025-03-27 |
| Facial Skin Clinical and Microbial Profiling From Oral Probiotic Supplementation Probiotic with niacin and berry extract, Probiotic without niacin and berry extract, Placebo - Healthy, Skin Manifestations | Not applicable | Completed | Oriflame Cosmetics AB | 109 | 2022-09-26 | 2023-05-01 |
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Merck Sharp & Dohme LLC (19) · University of Pennsylvania (7) · National Heart, Lung, and Blood Institute (NHLBI) (6) · University of Washington (6) · Université de Sherbrooke (5) · Sanofi (4) · Abbott (3) · NYU Langone Health (3) · Yale University (3) · Albert Einstein College of Medicine (2) · Baylor College of Medicine (2) · Cedars-Sinai Medical Center (2) · Johns Hopkins University (2) · Ludwig-Maximilians - University of Munich (2) · Mayo Clinic (2)
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Benjamin Kelmendi, MD (2) · Chandramohan Wakade, MBBS (2) · Kirsten C Morley, PhD (2) · Meredith Hawkins, M.D., M.S. (2) · Michael Gaynon, MD (2) · Richard L Dunbar, MD (2) · Roopal Thakkar, MD (2) · Stephen Ross, MD (2) · Xue-Qiao Zhao, MD (2) · Aaron I Vinik, MD, PhD (1) · Alexandra Calmy, MD (1) · Andreas Birkenfeld, MD, PhD (1)
PMID 21401833, PMID 22500948, PMID 26708287, PMID 34134520, PMID 25084698, PMID 25216871, PMID 25245415, PMID 29301785, PMID 17392721, PMID 17643572, PMID 18765395, PMID 19301936, PMID 19331435, PMID 19557844, PMID 19576324, PMID 19833861, PMID 19874992, PMID 20216298, PMID 20518948, PMID 20819978, PMID 20888102, PMID 21120461, PMID 21227624, PMID 21231862, PMID 21291704, PMID 21291812, PMID 21493792, PMID 21565796, PMID 21920335, PMID 22085343, PMID 22338103, PMID 22400810, PMID 22406532, PMID 22658147, PMID 22892157, PMID 23168285, PMID 23174368, PMID 23299761, PMID 23460815, PMID 23497455, PMID 23522788, PMID 23640486, PMID 23881958, PMID 23884778, PMID 23916935, PMID 23926117, PMID 23973688, PMID 24166281, PMID 24206527, PMID 24267254
2015 (2), 2017 (2), K23HL091130 (2), 2004 (1), 2005 (1), K23MH122777 (1), P01HL023619 (1), P01HL030086 (1), P30CA023074 (1), R01AG021570 (1), R01DK037948 (1), R01DK040484 (1), R01DK045343 (1), R01DK061486 (1), R01DK069861 (1)