12 completed, 7 not yet recruiting, 3 recruiting, 2 unknown. 22 Not applicable, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 11, Not yet recruiting 6, Recruiting 3, Unknown 2 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Interactions Between Placebo Effects and Mindful Awareness State tDCS stimulation (sham), tDCS stimulation (real), Mindful state induction - Placebo Effect, Mindfulness | Not applicable | Not yet recruiting | Trustees of Dartmouth College | 120 | 2027-06-01 | 2026-10-07 |
| Placebo Effect on Cycling Performance: Laboratory Crossover Study Caffeine (6mg/kg), Placebo (Starch capsule) - Physical Performance, Placebo Effect | Not applicable | Not yet recruiting | Poznan University of Physical Education | 80 | 2027-01-01 | 2026-09-18 |
| Context Interventions: Social Modeling and Initial Treatment Experience Observed Success, Observed Failure, Experienced Success - Placebo Effect, Pain | Not applicable | Not yet recruiting | Trustees of Dartmouth College | 120 | 2026-12-01 | 2026-01-16 |
| Placebo Effect in Field-Based Physical Performance Caffeine (6mg/kg), Placebo (Starch capsule), Sham (No Treatment) - Physical Performance, Placebo Effect | Not applicable | Not yet recruiting | Poznan University of Physical Education | 120 | 2026-09-01 | 2026-08-03 |
| The Role of the Opioid System in Placebo Effects on Pain and Social Rejection Placebo Cream with Naloxone, Control Cream with Naloxone, Placebo Cream with Saline - Pain, Rejection | Early Phase 1 | Not yet recruiting | Trustees of Dartmouth College | 60 | 2026-09-01 | 2025-12-09 |
| Efficacy of Attention Bias Modification vs. Placebo for Social Anxiety Disorder Dot-Probe Attention Bias Modification (ABM), Placebo Training - Social Anxiety Disorder (SAD), Attention Bias Modification Treatment (ABMT) | Not applicable | Recruiting | Tel Aviv University | 90 | 2026-06-15 | 2026-06-24 |
| Effects of Conditioning Activities in Female Athletes post-activation performance enhancement (PAPE) protocol - Placebo Effect, Physical Performance | Not applicable | Not yet recruiting | Universidade Federal do Triangulo Mineiro | 20 | 2026-05-10 | 2026-04-23 |
| Neural Mechanisms of Interpersonal Expectations on Negative Affect Session A: Positive Placebo + Active tTIS, Session B: Positive Placebo + Sham tTIS, Session C: Negative Placebo + Active tTIS - Negative Affectivity, Non-invasive Brain Stimulation | Not applicable | Recruiting | Trustees of Dartmouth College | 196 | 2025-09-01 | 2026-06-11 |
| Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper Positive Expectation, Negative Expectation, Control - Placebo Effect, Nocebo Effect | Not applicable | Not yet recruiting | Canterbury Christ Church University | 56 | 2025-03-01 | 2025-02-19 |
| A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication. Virtual Statin Management (VSM) - Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia | Not applicable | Completed | University of Utah | 898 | 2024-10-24 | 2026-05-29 |
| The Role of Attention in Modulating the Placebo Effect Placebo - Placebo Effect, Attention | Not applicable | Recruiting | Catholic University of the Sacred Heart | 128 | 2024-03-07 | 2025-02-14 |
| Clinical Predictive Effects of Mulligan Treatment in Patients With Chronic Neck Pain Mobilization With Movement Technique - Orthopedic Disorder of Spine, Placebo Effect | Not applicable | Completed | Universidad Europea de Madrid | 42 | 2021-08-02 | 2022-04-01 |
| Attention and Pain in Children With and Without Attention Deficit and/or Hyperactivity Disorder Placebo and nocebo effect - Attention Deficit Disorder With Hyperactivity, Placebo Effect | Not applicable | Unknown | Université de Sherbrooke | 44 | 2021-02-17 | 2022-07-28 |
| The Influence of Expectations on Post-needling Soreness and Pain Processing After Dry Needling Treatment Dry Needling - Placebo Effect, Pain Intensity | Not applicable | Completed | Universidad Europea de Madrid | 42 | 2020-10-01 | 2022-04-18 |
| The Effect of Tablet Size on Cognitive Performance Caffeine Caffeine Anhydrous with small sucrose pill, Placebo - large sucrose pill, Caffeine Anhydrous with large sucrose pill - Placebo Effect | Phase 4 | Completed | University of Colorado, Denver | 120 | 2018-10-31 | 2019-04-17 |
| Experimental Pain Reporting Accuracy and Placebo Response Placebo - Healthy, Placebo Effect | Not applicable | Unknown | University of Haifa | 100 | 2017-08-13 | 2019-05-15 |
| Non-Specific Effects of Manual Therapy Spinal Manual Therapy - Musculoskeletal Manipulations, Placebo Effect | Not applicable | Completed | Shenandoah University | 24 | 2017-01-01 | 2017-10-09 |
| Effects of Open-label vs Double-blind Treatment in IBS placebo, peppermint oil - Irritable Bowel Syndrome, Placebo Effect | Not applicable | Completed | Beth Israel Deaconess Medical Center | 340 | 2016-06-01 | 2024-01-22 |
| Back to Basics - Effects, Narratives and Routes of Administration of Open-label Placebo open-label placebo, deceptive placebo - Placebo Effect, Pain | Not applicable | Completed | University Hospital, Basel, Switzerland | 160 | 2016-01-01 | 2017-07-26 |
| Smartphone Application, Mood and Stress No expectancy (control), Prospective expectancy, Retrospective expectancy - Smartphone Application, Placebo Effect | Not applicable | Completed | University Hospital, Basel, Switzerland | 132 | 2015-02-01 | 2016-03-31 |
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Pain (9) · Attention Deficit Disorder with Hyperactivity (1) · Cardiovascular Diseases (1) · Hypercholesterolemia (1) · Irritable Bowel Syndrome (1) · Myalgia (1) · Neck Pain (1) · Phobia, Social (1) · Rejection, Psychology (1)
Neurologic Manifestations (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Mental Disorders (2) · Anxiety Disorders (1) · Attention Deficit and Disruptive Behavior Disorders (1) · Behavior (1) · Colonic Diseases (1) · Colonic Diseases, Functional (1) · Digestive System Diseases (1) · Dyslipidemias (1) · Gastrointestinal Diseases (1) · Hyperlipidemias (1) · Intestinal Diseases (1) · Lipid Metabolism Disorders (1)
Caffeine (4) · Starch (2) · salicylhydroxamic acid (2) · Acetaminophen (1) · Cephalexin (1) · Clinical Protocols (1) · Dry Needling (1) · Hydroxyzine (1) · Ibuprofen (1) · Longitudinal Studies (1) · Naloxone (1) · Nocebo Effect (1) · Sodium Chloride (1) · Sugars (1) · peppermint oil (1)
Trustees of Dartmouth College (4) · King Faisal Specialist Hospital & Research Center (3) · University Hospital, Basel, Switzerland (3) · Poznan University of Physical Education (2) · Universidad Europea de Madrid (2) · Beth Israel Deaconess Medical Center (1) · Canterbury Christ Church University (1) · Catholic University of the Sacred Heart (1) · Shenandoah University (1) · Tel Aviv University (1) · Universidade Federal do Triangulo Mineiro (1) · University of Colorado, Denver (1) · University of Haifa (1) · University of Utah (1) · Université de Sherbrooke (1)
United States (8) · Saudi Arabia (3) · Switzerland (3) · Israel (2) · Poland (2) · Spain (2) · Brazil (1) · Canada (1) · Italy (1) · United Kingdom (1)
Jakub Malik, PhD (2) · Jens Gaab, Prof (2) · Tor D Wager, PhD (2) · Daniel Hernandez Altamirano (1) · Francesca NA Grosso, MD (1) · Gunther Meinlschmidt, Prof. Dr. (1) · Gustavo Ribeiro da Mota, PhD (1) · Jordan B King, PharmD, MS (1) · Muhammad M Hammami, MD, PhD (1) · Sheri A Hale, PT, PhD, ATC (1) · Tor Wager, Ph.D. (1) · Yair Bar-Haim, PhD (1)
PMID 19119402, PMID 21092089, PMID 23254550, PMID 23965945, PMID 27899067, PMID 28535819, PMID 28545508, PMID 31736781, PMID 32820135, PMID 33594991, PMID 33605656, PMID 33921101, PMID 34408060, PMID 39853660
R01AT008573 (1), R01HL157439 (1)