13 completed, 3 terminated, 3 unknown, 2 not yet recruiting. 11 Phase 4, 4 Not applicable, 3 Phase 2, 2 Phase 1, 2 Phase 3.
Follow Hydroxyzine: new trials by email Literature Review of Hydroxyzine trials Research Report on Hydroxyzine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigating Pre-Procedural Anxiety and Effect of Analgesia on Intrauterine Device Placement and Endometrial Biopsy Paracervical block- Lidocaine without epinephrine, Benzocaine Gel applied to the cervix, Hydroxyzine Hydrochloride - Anxiety, Pain | Phase 2 | Not yet recruiting | The University of Texas Health Science Center, Houston | 152 | 2025-07-01 | 2025-06-22 |
| Efficacy of Hydroxyzine for Patients With Panic Disorder Hydroxyzine, Escitalopram Oxalate - Panic Disorder | Phase 4 | Not yet recruiting | Sultan Qaboos University | 80 | 2023-12-30 | 2023-02-21 |
| Comparison Between Oral Melatonin and Hydroxyzine in Pediatric Patients Undergoing Adenotonsillectomy Melatonin 3 MG, Hydroxyzine Pill, Placebo - Effect of Drug, Anxiety | Phase 1 | Unknown | Minia University | 78 | 2023-02-01 | 2023-12-27 |
| Melatonin Versus Hydroxizin for Pre Operative Anxiety in Elderly Patients With Hip Fracture Melatonin 5 MG Sublingual Tablet, Hydroxyzine - Preoperative Anxiety | Not applicable | Unknown | Mongi Slim Hospital | 50 | 2022-03-01 | 2022-02-04 |
| Sedation and Nursing Management in EEG Recording in Children Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine - Electroencephalography, Melatonin | Not applicable | Completed | Suleyman Demirel University | 180 | 2021-01-01 | 2022-08-09 |
| Preoperative Use of Alprazolam and Hydroxyzine in Anxiety Hydroxyzine Hydrochloride, Alprazolam tablet, Placebo - Agitation on Recovery From Sedation | Phase 4 | Unknown | Istanbul Medeniyet University | 90 | 2019-12-01 | 2019-12-06 |
| Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years Meperidine, Hydroxyzine, Midazolam - Dental Caries in Children, Pediatric Dental Sedation | Phase 4 | Completed | University of Washington | 37 | 2019-06-25 | 2024-01-24 |
| Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment Varenicline Pill, Hydroxyzine Pill - Smoking Cessation, Stress | Phase 4 | Completed | Rose Research Center, LLC | 26 | 2019-06-17 | 2023-03-03 |
| Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms Aprepitant 80 mg, Hydroxyzine 25mg, Placebo of Hydroxyzine - Myeloproliferative Disorder, Aquagenic Pruritus | Phase 3 | Completed | University Hospital, Brest | 63 | 2019-04-16 | 2025-12-03 |
| Hydroxyzine Dihydrochloride Premedication is a Necessity for Strabismus Surgery Midazolam, Hydroxyzine Dihydrochloride - Strabismus, Reflex, Oculocardiac | Completed | Yeditepe University | 45 | 2018-10-01 | 2019-10-22 | |
| Presurgery Anxiolysis in Children Treated With Hydroxyzine Versus Non-pharmacological Intervention (Distractoria Technique Clown) Hydroxyzine, Clowns intervention - Anxiety | Phase 4 | Terminated | Hospital San Carlos, Madrid | 170 | 2017-11-01 | 2020-08-11 |
| E7 TCR T Cells for Human Papillomavirus-Associated Cancers E7 TCR cells, Aldesleukin, Fludarabine - Papillomavirus Infections, Cervical Intraepithelial Neoplasia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 224 | 2017-01-27 | 2026-03-09 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| Interaction Between Drug and Placebo Effect:Randomized Placebo Controlled Trials May Not be Accurate in Determining Drug Effect Size Hydroxizine, Placebo, hydroxyzine/placebo - Placebo Effect, Placebo Drug Interaction | Not applicable | Completed | King Faisal Specialist Hospital & Research Center | 480 | 2012-11-01 | 2017-03-03 |
| Effects of Levocetirizine and Hydroxyzine on Cognitive and Psychomotor Functioning During Simulated Diving Levocetirizine, Hydroxyzine, Placebo - Healthy Volunteers | Phase 4 | Completed | Utrecht Institute for Pharmaceutical Sciences | 24 | 2012-04-01 | 2013-11-06 |
| Does Hydroxyzine Decrease Anxiety in Underweight Patients Diagnosed With an Eating Disorder Hydroxyzine, hydroxyzine HCL, Placebo - Anxiety in Those Patients With Anorexia Nervosa, Eating Disorder Not Otherwise Specified, BMI (<=18) | Phase 4 | Withdrawn | HealthPartners Institute | 2012-01-01 | 2016-11-15 | |
| Levocetirizine Plus Bed-Time Hydroxyzine in the Management of Corticodependent Chronic Urticaria Versus Levocetirizine Alone in High Doses Levocetirizine, Levocetirizine plus Hydroxyzine - Chronic Urticaria | Phase 4 | Completed | Association Asthma, Bulgaria | 24 | 2011-03-01 | 2013-07-17 |
| Pain and Anxiety Management of Traumatic Emergency in a Pre-hospital Setting Atarax (Hydroxyzine), Placebo - Pain | Phase 4 | Completed | University Hospital, Toulouse | 140 | 2010-05-01 | 2014-07-23 |
| Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal Palonosetron, Hydroxyzine, Placebo - Substance-Related Disorders | Not applicable | Completed | Stanford University | 10 | 2008-04-01 | 2017-06-05 |
| Hydroxyzine for the Prevention of Pruritus From Spinal Morphine in Transabdominal Hysterectomy Patients hydroxyzine - Pruritus, Nausea | Phase 4 | Completed | Mahidol University | 80 | 2007-08-01 | 2010-03-29 |
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Anxiety Disorders (6) · Nausea (2) · Pain (2) · Acute Pain (1) · Carcinoma in Situ (1) · Chronic Urticaria (1) · Dementia (1) · Depression (1) · Hip Fractures (1) · Myeloproliferative Disorders (1) · Panic Disorder (1) · Papillomavirus Infections (1) · Parasomnias (1) · Pruritus (1) · Psychophysiologic Disorders (1)
Association Asthma, Bulgaria (1) · Hannover Medical School (1) · HealthPartners Institute (1) · Hospital San Carlos, Madrid (1) · Istanbul Medeniyet University (1) · J. Uriach and Company (1) · King Faisal Specialist Hospital & Research Center (1) · Mahidol University (1) · Minia University (1) · Mongi Slim Hospital (1) · National Cancer Institute (NCI) (1) · Poitiers University Hospital (1) · Rose Research Center, LLC (1) · Stanford University (1) · Suleyman Demirel University (1)
United States (6) · France (3) · Netherlands (2) · Turkey (Türkiye) (2) · Bulgaria (1) · Egypt (1) · Germany (1) · Saudi Arabia (1) · Spain (1) · Thailand (1)
Dr Larry Fu-nien Chu (1) · Dr. Phuriphong Songarj, MD (1) · Erik Vuurman, PhD (1) · Esther Aleo Lujan, MD (1) · Ferda F Kartufan, Assist.Prof (1) · Helge Frieling, Prof., MD (1) · Joris Verster, PhD (1) · Marcus Westerman, MD, PhD (1) · Pamela Berens, MD (1) · Sarah Omar (1) · Scott M Norberg, D.O. (1) · Todor A Popov, MD, PhD (1)
PMID 27712113, PMID 27899067, PMID 31898511, PMID 33558725, PMID 34805403, PMID 34923994, PMID 36189149
2009 (1), 2018 (1)