30 completed, 16 recruiting, 15 unknown, 5 not yet recruiting. 34 Not applicable, 6 Phase 4, 4 Phase 1, 3 Early Phase 1, 2 Phase 3.
Follow Pituitary Adenoma: new trials by email Literature Review of Pituitary Adenoma trials Research Report on Pituitary Adenoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| AI in Endoscopic Transsphenoidal Surgery Live intra-op AI analysis of endoscopic video feed, with output displayed on supplementary monitor - Pituitary Adenoma | Early Phase 1 | Not yet recruiting | University College, London | 30 | 2026-06-01 | 2026-05-05 |
| Standardized Patient Education in Pituitary Surgery Standardized Pituitary Training - Pituitary Adenoma | Not applicable | Not yet recruiting | Uludag University | 102 | 2026-06-01 | 2026-06-01 |
| FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET - Cushing Disease, Pituitary Adenoma | Early Phase 1 | Recruiting | Mayo Clinic | 50 | 2026-04-27 | 2026-10-30 |
| DDAVP for Pituitary Adenoma Desmopressin acetate - Cushing's Disease, Pituitary Adenoma | Not applicable | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 22 | 2026-03-09 | 2026-04-09 |
| Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery Anti-fog suction device-a 4 Fr multi-channel silicone catheter - Pituitary Adenoma, Craniopharyngioma | Not applicable | Recruiting | West China Hospital | 20 | 2026-03-01 | 2026-06-30 |
| Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas FET-PET/MRI - Pituitary Adenoma | Phase 1 | Recruiting | Mayo Clinic | 5 | 2026-01-08 | 2026-03-09 |
| Prediction Model for Postoperative Headache After Transsphenoidal Pituitary Surgery Transsphenoidal Pituitary Surgery - Headache, Pituitary Adenoma | Active not recruiting | Beijing Tiantan Hospital | 500 | 2026-01-01 | 2026-03-03 | |
| Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region. Standard-of-care PET/CT, NeuroEXPLORER - Dementia, Movement Disorders | Not applicable | Enrolling by invitation | prof. dr. Koen Van Laere | 1600 | 2025-09-30 | 2026-05-19 |
| Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors Proton Beam Therapy, Photon Radiotherapy - Primary Brain Tumors, Diffuse Glioma | Not applicable | Recruiting | Tata Memorial Centre | 156 | 2025-07-01 | 2025-09-16 |
| The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction Endoscopic endonasal skull base surgery - Meningioma, Pituitary Disease | Recruiting | Universitaire Ziekenhuizen KU Leuven | 154 | 2025-03-18 | 2025-04-23 | |
| A Twenty-years' Experience in Pituitary Disease. Frequency of disease recurrence - Pituitary Adenoma, Pituitary Cancer | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 1600 | 2025-03-10 | 2025-05-15 | |
| Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors Hormone replacement therapy, Placebo - Pituitary Adenoma, Pituitary Neuroendocrine Tumor | Phase 4 | Recruiting | Beijing Tiantan Hospital | 882 | 2024-12-04 | 2025-01-14 |
| Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection 11C-Methionine PET/CT - Cushing's Disease, Hypercortisolism | Not yet recruiting | Imperial College London | 15 | 2024-12-03 | 2024-12-03 | |
| Effect of Foot Bath on Anxiety and Physiological Parameters Warm water foot bath - Pituitary Adenoma, Surgery | Not applicable | Completed | Trakya University | 100 | 2024-09-25 | 2026-04-21 |
| Molecular Pituitary Imaging Using 18F-FET PET 18F-Fluoro-ethyl-tyrosine (FET) PET - Pituitary Adenoma | Not applicable | Recruiting | University of Cambridge | 20 | 2024-09-03 | 2026-01-06 |
| Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models Endocrine Disorders, Adiposity | Not yet recruiting | IRCCS San Raffaele | 200 | 2024-07-01 | 2024-06-11 | |
| Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors Contrast enhanced pituitary magnetic resonance imaging (MRI), Contrast enhanced ultrasound, Non-Contrast Ultrasound - Pituitary Adenoma, Cushing Disease | Recruiting | Mayo Clinic | 110 | 2024-06-19 | 2026-01-13 | |
| Cabergoline in the Management of Nonfunctioning Pituitary Adenoma Cabergoline 0.5 MG - Pituitary Adenoma, MRI | Phase 4 | Enrolling by invitation | National Taiwan University Hospital | 30 | 2024-05-20 | 2025-06-24 |
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Pituitary Neoplasms (75) · Meningioma (7) · Pituitary Diseases (7) · Brain Neoplasms (6) · Pituitary ACTH Hypersecretion (5) · Cushing Syndrome (4) · Acromegaly (3) · Adenoma (2) · Craniopharyngioma (2) · Medulloblastoma (2) · Neuroblastoma (2) · Neuroendocrine Tumors (2) · Paraganglioma (2) · Prolactinoma (2) · ACTH-Secreting Pituitary Adenoma (1)
Brain Diseases (75) · Central Nervous System Diseases (75) · Endocrine Gland Neoplasms (75) · Hypothalamic Diseases (75) · Hypothalamic Neoplasms (75) · Neoplasms by Site (75) · Nervous System Diseases (75) · Nervous System Neoplasms (75) · Supratentorial Neoplasms (75) · Central Nervous System Neoplasms (74) · Endocrine System Diseases (74) · Neoplasms (74) · Brain Neoplasms (69) · Pituitary Diseases (68) · Neoplasms by Histologic Type (16)
Cabergoline (3) · Hydrocortisone (2) · Propofol (2) · Proton Therapy (2) · Sevoflurane (2) · Surgical Procedures, Operative (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Aminolevulinic Acid (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Blood Specimen Collection (1) · Cefdinir (1) · Continuous Glucose Monitoring (1) · Critical Pathways (1) · Deamino Arginine Vasopressin (1) · Desflurane (1)
Peking Union Medical College Hospital (4) · St. Joseph's Hospital and Medical Center, Phoenix (4) · Beijing Tiantan Hospital (3) · Federico II University (3) · Huashan Hospital (3) · Mayo Clinic (3) · University College, London (3) · University Hospital, Basel, Switzerland (3) · Seoul National University Hospital (2) · Universitaire Ziekenhuizen KU Leuven (2) · Affiliated Hospital of Nantong University (1) · British Columbia Cancer Agency (1) · Cardiff University (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Universitaire de Nice (1)
United States (17) · China (14) · Italy (6) · Switzerland (4) · United Kingdom (4) · Belgium (3) · Canada (3) · France (3) · Germany (3) · Netherlands (3) · South Korea (3) · Turkey (Türkiye) (3) · Czechia (2) · Taiwan (2) · Austria (1)
Bing Xing, MD (3) · Gilda Cennamo (3) · Wei Lian, MD (3) · Andrew Little, MD (2) · Ahmad M. Al-Arman (1) · Aled Rees, MB BCh, PhD (1) · Andrej Pala, MD (1) · Andrew S Little, MD (1) · Andrew S. Little, MD (1) · Carlo Serra, MD (1) · Chul-Kee Park, MD PhD (1) · David M Kleinberg, MD (1) · Deborah P Merke, M.D. (1) · Derek Johnson, MD (1)
PMID 16509142, PMID 1738293, PMID 17695407, PMID 17862444, PMID 18780796, PMID 19240574, PMID 19970261, PMID 21748460, PMID 22154461, PMID 22863387, PMID 23662829, PMID 25418156, PMID 25839931, PMID 25884256, PMID 25923040, PMID 26473774, PMID 27150495, PMID 27864853, PMID 28820308, PMID 28952907, PMID 29297053, PMID 30144606, PMID 30215565, PMID 30540568, PMID 30649445, PMID 30901746, PMID 31079156, PMID 31377966, PMID 31731279, PMID 31832214, PMID 31857533, PMID 32893266, PMID 33068429, PMID 34620658, PMID 35275019, PMID 35661809, PMID 35954244, PMID 36383383, PMID 38274233, PMID 38498406, PMID 38553990, PMID 38918132, PMID 38963694, PMID 39202235, PMID 39390132, PMID 39852769, PMID 40760415, PMID 41689093
2018 (1), R01NS070600 (1)