193 completed, 60 unknown, 43 recruiting, 18 terminated. 171 Not applicable, 26 Phase 2, 20 Phase 1, 19 Phase 3, 17 Phase 4.
Follow Peripheral Artery Disease: new trials by email Literature Review of Peripheral Artery Disease trials Research Report on Peripheral Artery Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| FRAME, External Support for Lower Limb Autologous Grafts FRAME - Peripheral Arterial Disease, Peripheral Artery Disease | Not applicable | Suspended | Vascular Graft Solutions Ltd. | 30 | 2026-12-31 | 2025-02-04 |
| PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease | Not yet recruiting | Medical College of Wisconsin | 60 | 2026-12-01 | 2025-10-14 | |
| IV-X Medical First-in-Human Peripheral Intravascular Lithotripsy Study for PAD IV-X Medical IVL System - Peripheral Artery Disease | Not applicable | Active not recruiting | IVX Medical | 25 | 2026-09-15 | 2026-10-21 |
| Rotational Atherectomy and Drug-Coated Balloon Angioplasty With Embolic Protection for Superficial Femoral Artery Occlusions Rotational Atherectomy With Distal Embolic Protection and Drug-Coated Balloon Angioplasty - Peripheral Artery Disease, Atherectomy in Diseased Lower Extremity Arteries | Not applicable | Not yet recruiting | Sakarya University | 60 | 2026-09-01 | 2026-09-04 |
| Home-based Exercise Therapy in Patients With Moderate to Severe Peripheral Artery Disease Home-Based Exercise Therapy Using Portable Pedal Exerciser - Peripheral Artery Disease | Not applicable | Recruiting | Laval University | 12 | 2026-06-23 | 2026-06-26 |
| Revascularization With Modification Using Definitive IVL and Serration Remodeling for Optimal Lumen Serranator Sonic Intravascular Lithotripsy (IVL) System - Peripheral Artery Disease | Not applicable | Not yet recruiting | Cagent Vascular LLC | 30 | 2026-05-01 | 2026-05-08 |
| an Observational Study Evaluting the Effectiveness and Safety of DKutting LL Noval Scoring Balloon Angioplasty for Vessel Preparation Facilitated by IVUS on the Lower Limb Ischemia Patients With Calcified Lesions DKutting LL scoring balloon angioplasty - Femoral Artery Stenosis, Angioplasty | Enrolling by invitation | The First Affiliated Hospital of Dalian Medical University | 58 | 2026-03-17 | 2026-04-03 | |
| The Value of Super-resolution Ultrasound Imaging for Peripheral Artery Disease Peripheral Artery Disease | Recruiting | Peking University First Hospital | 300 | 2026-02-08 | 2026-05-18 | |
| Prevalence of Obstructive Sleep Apnea in Patients With Peripheral Arterial Occlusive Disease Peripheral Artery Disease | Recruiting | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | 295 | 2025-11-05 | 2026-07-07 | |
| Truway Diagnostic Tools in Primary Care Truway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent - Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight | Early Phase 1 | Enrolling by invitation | Truway Health, Inc. | 200 | 2025-10-01 | 2025-10-24 |
| Improving Mobility After Revascularization in Peripheral Artery Disease Home Based Exercise, Nitrate Rich Beetroot Juice, Attention Control - Peripheral Artery Disease, Intermittent Claudication | Phase 3 | Recruiting | Northwestern University | 386 | 2025-08-04 | 2026-10-05 |
| Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee Temsirolimus, Saline placebo - Peripheral Artery Disease, Critical Limb Ischemia | Phase 3 | Recruiting | Mercator MedSystems, Inc. | 250 | 2025-07-30 | 2025-08-05 |
| Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave No intervention - Coronary Disease, Myocardial Infarction | Completed | Universitätsklinikum Hamburg-Eppendorf | 176 | 2025-06-11 | 2026-05-29 | |
| Improving Walking Performance in Patients With Peripheral Artery Disease Through Wearable Activity Trackers supervised exercise therapy (SET), Wearable activities monitor (WAM), enhanced HBET - Peripheral Artery Disease | Not applicable | Recruiting | Chinese University of Hong Kong | 70 | 2025-06-01 | 2025-06-10 |
| Study on PAD and CAS Based on Omics and Imaging Peripheral Artery Disease, Carotid Artery Stenosis | Not yet recruiting | Yijie Ning | 100 | 2025-04-01 | 2025-04-08 | |
| Response to Exercise and Nitric Oxide in PAD Supervised Treadmill Exercise, Attention Control, Nitrate-Rich Beetroot Juice + supervised exercise therapy - Peripheral Artery Disease, Exercise | Phase 2 | Recruiting | Northwestern University | 200 | 2025-01-23 | 2026-07-27 |
| Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease Vumerity, Placebo - Peripheral Artery Disease, Peripheral Vascular Diseases | Early Phase 1 | Recruiting | University of Nebraska | 20 | 2024-11-14 | 2026-06-24 |
| Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization Coronary computed topography (CT) angiography with FFR-CT - Peripheral Artery Disease, Coronary Artery Disease | Not applicable | Withdrawn | VA Office of Research and Development | 2024-11-01 | 2025-09-26 | |
| The THOR IDE Study Thor laser atherectomy - Peripheral Artery Disease, Peripheral Artery Stenosis | Not applicable | Recruiting | Philips Clinical & Medical Affairs Global | 155 | 2024-10-29 | 2026-06-11 |
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Peripheral Arterial Disease (353) · Intermittent Claudication (55) · Peripheral Vascular Diseases (39) · Chronic Limb-Threatening Ischemia (32) · Atherosclerosis (27) · Coronary Artery Disease (19) · Diabetes Mellitus (18) · Cardiovascular Diseases (17) · Motor Activity (15) · Vascular Diseases (14) · Arterial Occlusive Diseases (10) · Diabetes Mellitus, Type 2 (9) · Peripheral Arterial Occlusive Disease 1 (9) · Hypertension (8) · Heart Failure (7)
Arteriosclerosis (348) · Arterial Occlusive Diseases (343) · Vascular Diseases (339) · Cardiovascular Diseases (336) · Atherosclerosis (326) · Peripheral Vascular Diseases (314) · Pathological Conditions, Signs and Symptoms (112) · Signs and Symptoms (64) · Pathologic Processes (53) · Disease Attributes (39) · Chronic Disease (38) · Ischemia (38) · Nutritional and Metabolic Diseases (32) · Endocrine System Diseases (31) · Metabolic Diseases (30)
Aspirin (8) · Angioplasty (7) · Clopidogrel (7) · Exercise (7) · Rivaroxaban (6) · Ticagrelor (5) · Atherectomy (4) · Cilostazol (4) · Standard of Care (4) · Surveys and Questionnaires (3) · Transcutaneous Electric Nerve Stimulation (3) · cholesterol-binding protein (3) · Angioplasty, Balloon (2) · Ankle Brachial Index (2) · Atherectomy, Coronary (2)
Northwestern University (18) · C. R. Bard (11) · University Hospital, Angers (11) · Abbott Medical Devices (8) · VA Office of Research and Development (8) · University of Oklahoma (7) · Acotec Scientific Co., Ltd (6) · Biotronik AG (6) · University of Nebraska (6) · University of Minnesota (5) · University of Pennsylvania (5) · Universitätsklinikum Hamburg-Eppendorf (5) · Concept Medical Inc. (4) · NYU Langone Health (4) · Philips Clinical & Medical Affairs Global (4)
United States (151) · Germany (53) · France (32) · China (25) · Austria (23) · Italy (22) · Belgium (20) · South Korea (14) · United Kingdom (14) · Spain (12) · Canada (11) · Singapore (10) · Switzerland (9) · Greece (8) · Netherlands (8)
Mary McDermott, MD (10) · Dierk Scheinert, MD (5) · Thomas Zeller, MD (5) · Alexander Fanaroff, MD, MHS (2) · Andrea Flex, MD, PhD (2) · Cory L. Christiansen, PhD (2) · Doo-Yeoun Cho, MD (2) · Edward Choke (2) · Karl Kuusik, MD (2) · Kenneth Rosenfield, MD (2) · Marianne Brodmann, MD (2) · Mary M McDermott, MD (2) · Michael Lichtenberg, MD (2) · Michael S Conte, MD (2)
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1IK2RX003546-01A2 (1), 2009 (1), 2014 (1), I21RX003877 (1), K01HL115534 (1), K01HL148639 (1), K23HL143178 (1), R01AG016685 (1), R01AG057693 (1), R01AG068458 (1), R01AG070086 (1), R01AG071778 (1), R01AG073257 (1), R01AG073634 (1), R01HL075721 (1)