46 completed, 18 recruiting, 13 unknown, 7 active not recruiting. 79 Not applicable, 4 Phase 2, 3 Phase 3, 2 Phase 4.
Follow Perinatal Depression: new trials by email Literature Review of Perinatal Depression trials Research Report on Perinatal Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Perinatal Mental Health Through a Collaborative, Community Health Worker and Social Worker Intervention Patient Navigation (PN), Problem Solving Therapy (PST) - Perinatal Anxiety, Perinatal Depression | Not applicable | Not yet recruiting | American University | 45 | 2027-01-01 | 2026-10-19 |
| Transcranial Magnetic Therapy (TMS) for Treatment of Perinatal Depression Transcranial Magnetic Stimulation (TMS) - Perinatal Depression | Not applicable | Active not recruiting | Rana Jawish | 100 | 2026-09-23 | 2026-11-10 |
| Group CBT for Paternal Perinatal Depression Cognitive Behavioral Therapy for Paternal Perinatal Depression - Perinatal Depression, Fathers | Not applicable | Not yet recruiting | McMaster University | 112 | 2026-09-15 | 2026-08-13 |
| Deconstructing Maternal Burdens: Doulas and the Community Unite for Health Doula, Standard (non-enhanced) Medicaid doula support - Pregnancy, Post Partum | Not applicable | Recruiting | University of Florida | 516 | 2026-09-15 | 2026-09-28 |
| Midwife-led Cognitive Behavioral Intervention for Perinatal Depression. Multisite RCT Midwife-led Cognitive Behaviroal Intervention - Perinatal Depression, Social Support | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 192 | 2026-09-15 | 2026-09-09 |
| Early Detection of Perinatal Depression With Wearable Technology Oura Ring (Photoplethysmography-based wearable ring), EmbracePlus Watch (Electrodermal activity wristband sensor) - Perinatal Depression | Not applicable | Not yet recruiting | Women's College Hospital | 10 | 2026-09-01 | 2026-08-25 |
| Reaching Calm: A Digital Intervention to Prevent Perinatal Anxiety Disorders Digital mental health intervention - Perinatal Anxiety, Anxiety Sensitivity | Not applicable | Recruiting | University of Massachusetts, Worcester | 60 | 2026-08-15 | 2026-09-17 |
| Parents and Babies Pilot Parents and Babies Virtual Group Intervention, Parents and Babies Hybrid Group Intervention - Perinatal Depression, Postpartum Depression (PPD) | Not applicable | Recruiting | Northwestern University | 16 | 2026-08-03 | 2026-08-06 |
| Effectiveness and Implementation of a Personalized mHealth Intervention for the Universal Prevention of Maternal Perinatal Mental Disorders The e-Perinatal intervention is a personalized mobile health (mHealth) program, Standard routine maternal care - Perinatal Depression, Perinatal Anxiety | Not applicable | Recruiting | University of Seville | 3000 | 2026-07-15 | 2026-07-16 |
| Feasibility and Implementation of Early Referral in Perinatal Mental Health The e-Perinatal intervention is a personalized mobile health (mHealth) program, Standard routine maternal care - Perinatal Depression, Perinatal Anxiety | Not applicable | Recruiting | University of Seville | 3000 | 2026-07-15 | 2026-07-16 |
| Virtual Forest-Based Mindfulness for Perinatal Mental Health Virtual Reality Forest Mindfulness Intervention, Conventional Mindfulness Intervention - Perinatal Anxiety, Perinatal Depression | Not applicable | Recruiting | National Taiwan University Hospital | 100 | 2026-06-16 | 2026-08-18 |
| Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study Perinatal depression online cognitive-behavioral therapy course, Clinical care (psychotherapy sessions) - Depression, Perinatal Depression | Not applicable | Recruiting | University of California, Los Angeles | 250 | 2026-05-01 | 2026-07-06 |
| Efficacy of Yoga-Based Intervention in Improving Mother-Child Bonding in Maternal Depression Add-on Yoga Intervention, Treatment as Usual(Medication Based) - Perinatal Depression, Postpartum Depression | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 52 | 2026-04-15 | 2026-04-07 |
| Center M Randomized Trial Center M - Perinatal Depression | Not applicable | Recruiting | Oregon Health and Science University | 160 | 2026-01-15 | 2026-11-12 |
| Pathways to Perinatal Mental Health Equity Program in Support of Moms (PRISM), PSI Peer Support - Perinatal Anxiety, Perinatal Depression | Not applicable | Recruiting | University of Massachusetts, Worcester | 1270 | 2025-12-05 | 2026-04-20 |
| Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health Doula Link - Perinatal Depression, Perinatal Anxiety | Not applicable | Recruiting | Beth Israel Deaconess Medical Center | 90 | 2025-10-21 | 2025-10-22 |
| Group Cognitive Behavioural Therapy for Paternal Perinatal Depression Cognitive Behavioral Therapy for Paternal Perinatal Depression - Perinatal Depression, Fathers | Not applicable | Active not recruiting | McMaster University | 48 | 2025-09-09 | 2026-01-26 |
| Accelerated TMS for Perinatal Depression Transcranial Magnetic Stimulation - Perinatal Depression, Post Partum Depression | Not applicable | Recruiting | Brigham and Women's Hospital | 24 | 2025-08-05 | 2026-09-18 |
| Clinical and Cost-effectiveness of an Online Self-help Intervention and a Face-to-face Intervention Versus Usual Care in Mothers at Moderate Risk for Perinatal Depression Online self-help, Maternal Mental Health Intervention (MaMHI), Usual Care - Perinatal Depression | Not applicable | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 210 | 2025-06-15 | 2025-06-18 |
| Feasibility Study and Pilot Hybrid Effectiveness-Implementation Trial for the Universal Prevention of Maternal Perinatal Mental Disorders as Normalized Routine Practice (e-Perinatal Pilot) e-Perinatal personalized mHealth intervention integrated into routine maternal care, Standard routine maternal care with general perinatal health information - Perinatal Depression, Perinatal Anxiety | Not applicable | Completed | University of Seville | 96 | 2025-05-02 | 2026-09-23 |
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Depression, Postpartum (26) · Anxiety Disorders (20) · Depression (18) · Depressive Disorder, Major (4) · COVID-19 (3) · Psychological Well-Being (3) · Mood Disorders (2) · Parasomnias (2) · Pregnancy Complications (2) · Stress Disorders, Post-Traumatic (2) · Stress, Psychological (2) · Substance-Related Disorders (2) · Acquired Immunodeficiency Syndrome (1) · Anhedonia (1) · Behavior (1)
Mental Disorders (47) · Behavior (27) · Depressive Disorder (27) · Urogenital Diseases (27) · Female Urogenital Diseases and Pregnancy Complications (26) · Mood Disorders (26) · Puerperal Disorders (25) · Pregnancy Complications (24) · Behavioral Symptoms (19) · Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Infections (4) · RNA Virus Infections (4) · Virus Diseases (4) · Coronaviridae Infections (3)
Therapeutics (4) · Cognitive Behavioral Therapy (3) · Patient Navigation (2) · Pregnancy (2) · Telemedicine (2) · Transcranial Magnetic Stimulation (2) · Abortion, Legal (1) · Blood Specimen Collection (1) · DMAC2L protein, human (1) · Dialectical Behavior Therapy (1) · Docetaxel (1) · Docosahexaenoic Acids (1) · Doulas (1) · Estradiol (1) · Fish Oils (1)
Northwestern University (6) · National Taiwan University Hospital (3) · National University of Singapore (3) · Oregon Health and Science University (3) · University of Massachusetts, Worcester (3) · University of North Carolina, Chapel Hill (3) · University of Seville (3) · University of Washington (3) · Fangbiao Tao (2) · Human Development Research Foundation, Pakistan (2) · Kaiser Permanente (2) · McMaster University (2) · The Hong Kong Polytechnic University (2) · University of California, Los Angeles (2) · University of Iowa (2)
United States (41) · Canada (10) · China (7) · Pakistan (4) · Singapore (3) · Spain (3) · Taiwan (3) · Finland (2) · France (2) · Italy (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Denmark (1) · Ethiopia (1)
Darius Tandon, PhD (4) · Ellen Tilden, PhD, CNM, FACNM (3) · Emma Motrico, PhD (2) · Nancy Byatt, DO, MS, MBA (2) · Shefaly Shorey, PhD (2) · Abigail Lott, PhD (1) · An-Sofie Van Parys (1) · Andrea Temkin-Yu, Psy.D. (1) · Ariel Dalfen, MD, FRCPC (1) · Arne Beck, PhD (1) · Brian Pence, PhD (1) · Briana Woods-Jaeger, PhD (1) · Brittain L Mahaffey, PhD (1) · Chengli Tang (1)
PMID 20443658, PMID 20974776, PMID 23487258, PMID 30459138, PMID 30661630, PMID 31138319, PMID 31990493, PMID 32143644, PMID 32610640, PMID 33247023, PMID 33655429, PMID 33673867, PMID 33757591, PMID 34099007, PMID 34233989, PMID 34792478, PMID 35803896, PMID 36174135, PMID 36174746, PMID 36194458, PMID 3651732, PMID 36570810, PMID 36604685, PMID 36606005, PMID 36630005, PMID 36930182, PMID 36993880, PMID 37146219, PMID 37582274, PMID 37626428, PMID 37921846, PMID 37932648, PMID 38709329, PMID 38740296, PMID 38951777, PMID 39107820, PMID 39171074, PMID 39305680, PMID 39542133, PMID 39649162, PMID 39874578, PMID 39984893, PMID 40033113, PMID 40148939, PMID 40159324, PMID 40200057, PMID 40207735, PMID 40297330, PMID 40336702, PMID 40459806
R21MD011320 (2), 2023 (1), K01MD019724 (1), K01MH133966 (1), K23HD092888 (1), K23MD018092 (1), K23MH137382 (1), P50MH119029 (1), R01HD100395 (1), R01HD105499 (1), R01MH108548 (1), R01NR017620 (1), R01NR021399 (1), R21MD017396 (1), R21MH115806 (1)