11 completed, 1 active not recruiting, 1 recruiting, 1 unknown. 7 Phase 3, 2 Not applicable, 2 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 5, Recruiting 1, Unknown 1 |
| Not applicable | 2 | Active not recruiting 1, Completed 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
| Early Phase 1 | 1 | Completed 1 |
Follow Clodronic Acid: new trials by email Literature Review of Clodronic Acid trials Research Report on Clodronic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible modified PENTOCLO (mPENTOCLO), sham mPENTOCLO - Osteoradionecrosis, Osteoradionecrosis of Jaw | Phase 3 | Recruiting | Sunnybrook Health Sciences Centre | 24 | 2025-01-16 | 2025-09-12 |
| Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients Clodronate, Placebo - Osteoarthritis of Knee | Phase 2 / Phase 3 | Unknown | SPA Società Prodotti Antibiotici S.p.A. | 296 | 2023-10-12 | 2024-02-16 |
| Effect of Different Irrigation Protocols on Postoperative Endodontic Pain and Inflammation EDTA, Etidronate, clodronate - Irrigation Solution, Postoperative Pain | Not applicable | Active not recruiting | Suez Canal University | 75 | 2023-08-20 | 2025-08-11 |
| Combined Drug Therapy in Lateral Fragility Fractures of the Femur Clodronic Acid - Femur Fracture | Completed | Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari | 50 | 2019-05-01 | 2022-02-04 | |
| Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal Osteoporosis disodium clodronate 200 mg/4 ml with 1% lidocaine, Disodium clodronate 100 mg/3,3 ml with 1% lidocaine - Postmenopausal Osteoporosis | Phase 3 | Completed | Chiesi Farmaceutici S.p.A. | 260 | 2011-10-01 | 2017-03-30 |
| Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy Pentoxifylline placebo, Pentoxifylline, Tocopherol acetate - Radiation Induced Brachial Plexopathy | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 59 | 2011-03-01 | 2017-12-08 |
| Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment Clodronate (Bonefos, BAY94-8393) - Breast Neoplasms, Prostatic Neoplasms | Completed | Bayer | 147 | 2009-01-01 | 2012-09-07 | |
| S0307A, Long-Term Bone Quality in Women With Breast Cancer Enrolled on Clinical Trial SWOG-S0307 clodronate disodium, demeclocycline hydrochloride, ibandronate sodium - Breast Cancer | Withdrawn | SWOG Cancer Research Network | 2008-10-01 | 2013-04-10 | ||
| Bisphosphonates and Impaction Grafting in Hip Revision Clodronate, Placebo - Aseptic Loosening of the Hip Prosthesis | Phase 2 | Completed | Region Skane | 32 | 2008-03-01 | 2017-08-15 |
| Bonefos and the Consumption of Analgesics Bonefos (Clodronate, BAY94-8393) - Bone Neoplasms | Completed | Bayer | 149 | 2007-04-01 | 2012-04-06 | |
| S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer. clodronate disodium, ibandronate sodium, zoledronic acid - Breast Cancer | Phase 3 | Completed | SWOG Cancer Research Network | 6097 | 2005-07-01 | 2021-07-02 |
| Locally Administered Clodronate in the Prevention of Aseptic Implant Loosening Clodronate, Saline - Hip Arthrosis | Early Phase 1 | Completed | University of Oulu | 19 | 2004-03-26 | 2019-01-18 |
| Clodronate With or Without Chemotherapy and/or Hormonal Therapy in Treating Women With Stage I or Stage II Breast Cancer clodronate, placebo - Breast Cancer | Phase 3 | Completed | NSABP Foundation Inc | 3323 | 2001-01-01 | 2017-12-13 |
| Combination Chemotherapy in Treating Pain in Hormone Refractory Metastatic Prostate Cancer clodronate disodium, mitoxantrone hydrochloride, prednisone - Pain, Prostate Cancer | Phase 3 | Completed | NCIC Clinical Trials Group | 227 | 1997-11-24 | 2020-04-03 |
| Effects of Continuous Combined Hormone Replacement Therapy and Clodronate on Bone Mineral Density (BMD) in Osteoporotic Women Klodronate and Kliogest, Placebo+ Kliogest, Bonefos - Osteoporosis | Not applicable | Completed | Kuopio University Hospital | 167 | 1996-07-01 | 2009-04-07 |
Breast Neoplasms (5) · Prostatic Neoplasms (3) · Multiple Myeloma (2) · Bone Neoplasms (1) · Femoral Fractures (1) · Head and Neck Neoplasms (1) · Inflammation (1) · Osteoarthritis (1) · Osteoarthritis, Hip (1) · Osteoarthritis, Knee (1) · Osteolysis (1) · Osteoporosis (1) · Osteoporosis, Postmenopausal (1) · Osteoradionecrosis (1) · Pain (1)
Bayer (2) · SWOG Cancer Research Network (2) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari (1) · Chiesi Farmaceutici S.p.A. (1) · Kuopio University Hospital (1) · NCIC Clinical Trials Group (1) · NSABP Foundation Inc (1) · Region Skane (1) · SPA Società Prodotti Antibiotici S.p.A. (1) · Suez Canal University (1) · Sunnybrook Health Sciences Centre (1) · University of Oulu (1)
Italy (3) · Canada (2) · Czechia (2) · United States (2) · Egypt (1) · France (1) · Sweden (1)
Alexander H Paterson, MD, FRCP (1) · Ben Safa, MD (1) · Carla I. Falkson, MD (1) · Dalia Abdallah (1) · Dalia Fayyad (1) · Dawn Hershman, MD (1) · Donald S. Ernst, MD, FRCPC (1) · Elizabeth C. Dees, MD (1) · James N. Ingle, MD (1) · Julie R. Gralow, MD (1) · Magnus Tagil, MD, PhD (1) · Marjo T Tuppurainen, MD, PhD (1) · Mark J. Clemons, MD (1) · Norman Wolmark, MD (1)
PMID 38979716, PMID 12149294, PMID 12814333, PMID 12947070, PMID 20547017, PMID 22704583, PMID 22742890, PMID 32929540, PMID 33270906
U10CA032102 (1)