41 completed, 12 unknown, 7 not yet recruiting, 5 recruiting. 40 Not applicable, 8 Phase 2, 7 Phase 4, 6 Phase 1, 5 Phase 3.
Follow Osteoarthritis of Knee: new trials by email Literature Review of Osteoarthritis of Knee trials Research Report on Osteoarthritis of Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Geisinger Clinic | 75 | 2026-12-01 | 2026-09-03 |
| The Effect of Different Exercise Training Programs on Muscle Oxygenation in Individuals With Knee Osteoarthritis Recumbent-Cycle Aerobic Exercise, Lower-Limb Strengthening Exercise, Home Flexibility Exercise Program - Osteoarthritis of Knee | Not applicable | Recruiting | Bahçeşehir University | 60 | 2026-10-20 | 2026-10-29 |
| Robot-Aided Off-Axis Neuromuscular Training for Knee OA Robot-Aided Off-Axis Neuromuscular Training, Traditional elliptical regular stepping - Osteoarthritis of Knee | Not applicable | Not yet recruiting | University of Maryland, Baltimore | 36 | 2026-09-01 | 2026-07-28 |
| Evaluation of Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis No intervention - Osteoarthritis of Knee, Healthy Participants | Completed | Bahçeşehir University | 34 | 2026-03-01 | 2026-06-15 | |
| Cannabinoids for Osteoarthritis Pain Effectiveness Trial CBD, THC, Placebo - Osteoarthritis of Knee, Osteoarthritis Hip | Not applicable | Recruiting | University Health Network, Toronto | 100 | 2026-01-29 | 2026-07-16 |
| A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis SYN321, Placebo - Osteoarthritis of Knee | Phase 1 / Phase 2 | Completed | Synartro AB | 35 | 2025-08-19 | 2026-03-06 |
| Preoperative Rehabilitation Training and Total Knee Arthroplasty Outcomes Preoperative Rehabilitation Training - Osteoarthritis of Knee | Not applicable | Not yet recruiting | Fuzhou University Affiliated Provincial Hospital | 500 | 2025-08-01 | 2025-05-21 |
| The Effect of Balneotherapy on Knee Osteoarthritis Balneotherapy, home exercise program - Osteoarthritis of Knee | Not applicable | Not yet recruiting | Ahi Evran University Education and Research Hospital | 50 | 2025-07-01 | 2025-06-06 |
| Proprioceptive Fatigue Adaptation in Osteoarthritis Fatigue Protocol + Joint Position Sense Testing - Osteoarthritis of Knee, Proprioception | Not applicable | Not yet recruiting | Kocaeli Sağlık ve Teknoloji Üniversitesi | 20 | 2025-06-01 | 2025-05-14 |
| A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoarthritis of the Knee Cryopreserved Devitalized Adipose Tissue Allograft, Normal Saline (Placebo) - Osteoarthritis of Knee | Phase 1 / Phase 2 | Completed | Britecyte | 46 | 2025-05-05 | 2026-09-08 |
| A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms AMZ001 Diclofenac gel, Placebo gel - Osteoarthritis of Knee, Osteoarthritis, Knee | Phase 3 | Completed | Amzell | 549 | 2025-02-18 | 2026-07-15 |
| Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques Kinematic aligned total knee replacement - Arthritis, Arthritis (Knee) | Not applicable | Not yet recruiting | Université de Sherbrooke | 200 | 2025-02-01 | 2024-11-29 |
| Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? laparoscopic sleeve gastrectomy, total knee arthroplasty - Osteoarthritis of Knee, Arthroplasties, Knee Replacement | Not applicable | Not yet recruiting | Memorial University of Newfoundland | 142 | 2025-02-01 | 2025-01-30 |
| Knee Injections for Obese Patients With Knee Arthritis Triamcinolone Acetonide Low Dose, Triamcinolone Acetonide Standard Dose - Osteoarthritis of Knee | Phase 4 | Recruiting | Mayo Clinic | 40 | 2025-01-24 | 2026-03-10 |
| Evaluating the Effectiveness of Using a Home Laser Device to Treat Patients With Knee Osteoarthritis B-Cure laser pro, Sham - Osteoarthritis Of Knee | Not applicable | Recruiting | Barzilai Medical Center | 50 | 2025-01-14 | 2025-01-14 |
| RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK) Laser therapy + physiotherapy/exercise protocol, Sham Laser therapy + physiotherapy/exercise protocol - Osteoarthritis of Knee | Not applicable | Active not recruiting | DJO UK Ltd | 64 | 2024-11-23 | 2025-11-17 |
| Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries unilateral Radiofrequency, bilateral Radiofrequency, Epidural - Osteoarthritis of Knee | Not applicable | Completed | Ain Shams University | 66 | 2024-10-14 | 2026-08-05 |
| Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplantation Operation Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplantation Operation - Cartilage Damage, Osteochondral Lesion | Not applicable | Active not recruiting | Yeditepe University | 34 | 2024-10-09 | 2024-10-16 |
| Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms CAPPA, Health education - Osteoarthritis of Knee, Knee Pain Chronic | Not applicable | Completed | Marquette University | 39 | 2024-08-12 | 2026-04-01 |
| Electrical Dry Needling Versus Iontophoresis in Treating Chronic Unilateral Knee Osteoarthritis conventional physical therapy, Electrical Dry Needling, Glucosamine sulfate iontophoresis - Osteoarthritis of Knee | Not applicable | Completed | Horus University | 60 | 2024-06-01 | 2025-07-15 |
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Osteoarthritis, Knee (67) · Osteoarthritis (10) · Pain (5) · Motor Activity (3) · Obesity (3) · Arthritis (2) · Osteoarthritis, Hip (2) · Pain, Postoperative (2) · Acute Pain (1) · Arthralgia (1) · Bronchiolitis Obliterans Syndrome (1) · COVID-19 (1) · Depression (1) · Diabetes Mellitus, Type 2 (1) · Edema (1)
Musculoskeletal Diseases (67) · Rheumatic Diseases (67) · Joint Diseases (66) · Arthritis (65) · Osteoarthritis (57) · Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (12) · Neurologic Manifestations (9) · Behavior (4) · Pain (4) · Body Weight (3) · Nutrition Disorders (3) · Nutritional and Metabolic Diseases (3) · Overnutrition (3) · Overweight (3)
Exercise (5) · Duloxetine Hydrochloride (2) · Etanercept (2) · Adenosine Monophosphate (1) · Arthroplasty, Replacement, Knee (1) · Arthroscopy (1) · Balneology (1) · Bariatric Surgery (1) · Clodronic Acid (1) · Colchicine (1) · Dronabinol (1) · Educational Status (1) · Exercise Therapy (1) · Glucosamine (1) · Hyaluronic Acid (1)
Mahidol University (4) · Bahçeşehir University (2) · First Affiliated Hospital of Harbin Medical University (2) · Northwestern University (2) · Ottawa Hospital Research Institute (2) · Ahi Evran University Education and Research Hospital (1) · Ain Shams University (1) · Amzell (1) · Ankara City Hospital Bilkent (1) · Barzilai Medical Center (1) · Bioelectric Research Corporation (1) · Britecyte (1) · CDA Research Group, Inc. (1) · Cairo University (1) · China Medical University Hospital (1)
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Keerati Charoencholvanich, MD (3) · Yifang Mei, M.D (2) · Alexandre Sepriano, MD (1) · Alla Danilkovitch (1) · Ana Cristina R Lacerda, PhD (1) · Apiphan Iamchaimongkol, M.D. (1) · Ari Isaacson, MD (1) · Bernard Bonthoux, Physiotherap (1) · Bhibas Dasgupta, MS (1) · Candan Algun, PhD (1) · Cunzhi Liu, M.D (1) · Daniel Pinto, PhD (1) · Dr. Hance Clarke, MD (1)
PMID 22817651, PMID 23450020, PMID 27052991, PMID 27993154, PMID 28263500, PMID 30683147, PMID 31293437, PMID 32022581, PMID 32904642, PMID 33468249, PMID 33839803, PMID 34255959, PMID 40462058, PMID 40601162, PMID 9665594
2019 (1), 2023 (1), R21AR081007 (1), R37AG033906 (1)