17 completed, 11 unknown, 6 not yet recruiting, 4 recruiting. 23 Not applicable, 8 Phase 2, 2 Phase 3, 2 Phase 4, 1 Phase 1.
Follow Orofacial Pain: new trials by email Literature Review of Orofacial Pain trials Research Report on Orofacial Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Skills Training and Relief for Orofacial Pain Empowered Relief - Chronic Orofacial Pain, Orofacial Pain | Not applicable | Not yet recruiting | University of Kentucky | 200 | 2026-10-01 | 2026-10-05 |
| Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women Full-Spectrum Cannabis Extract 5:1 (CBD:THC) - Chronic Pain, Fibromyalgia | Phase 2 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 80 | 2026-09-01 | 2026-08-26 |
| Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur Orchestras Questionaire - Orofacial Pain, Sleep Bruxism | Recruiting | University Medical Center Goettingen | 400 | 2026-09-01 | 2026-09-04 | |
| Musicians' Health Education in D-A-CH Education, Medicine | Completed | University Medical Center Goettingen | 26 | 2026-05-09 | 2026-09-11 | |
| An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders Nerivio treatment - Temporomandibular Disorder, Orofacial Pain | Not applicable | Recruiting | Theranica | 100 | 2026-05-04 | 2026-10-14 |
| Identification of Possible Trigeminal Neuralgia Completion of the IDTN Questionnaire - Trigeminal Neuralgia (TN), Orofacial Pain | Not yet recruiting | University College, London | 250 | 2026-04-01 | 2026-03-23 | |
| Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders Individual physiotherapy, Group physiotherapy, Online physiotherapy - Temporomandibular Disorders (TMD), Orofacial Pain | Not applicable | Recruiting | Semmelweis University | 90 | 2026-03-01 | 2026-03-16 |
| Burning Mouth Syndrome: Effects of Occlusal Splint Therapy Essix splint - Burning Mouth Syndrome, Orofacial Pain | Not applicable | Not yet recruiting | Malmö University | 12 | 2026-01-15 | 2026-01-15 |
| Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain Lidocaine Intravenous Infusion, Ketamine intravenous infusion, Combined lidocaine and ketamine intravenous infusion - Orofacial Pain | Phase 2 | Not yet recruiting | Assiut University | 105 | 2026-01-01 | 2025-11-26 |
| Evaluation of the Efficacy of Neuromodulation in the Control of Chronic Orofacial Pain Active Neuromodulation (tDCS or TMS), Sham Neuromodulation (tDCS or TMS) - Orofacial Pain | Not applicable | Enrolling by invitation | Egas Moniz - Cooperativa de Ensino Superior, CRL | 50 | 2025-11-01 | 2026-02-20 |
| Feasibility Testing of the "Face-Forward-Web" Program for Chronic Orofacial Pain Face-Forward-Web - Orofacial Pain, Facial Pain | Not applicable | Completed | Massachusetts General Hospital | 20 | 2025-09-15 | 2026-10-07 |
| Validation and Evaluation of the Mastication Function in Adults: The Functional Six-minute Mastication Test (F-6MMT). Functional 6-minute mastication test - Mastication Disorder, Fatigue | Not yet recruiting | Fundació Universitària del Bages | 514 | 2025-09-01 | 2025-05-15 | |
| Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain Chlorzoxazone, Orphenadrine Citrate - Orofacial Pain, Bruxism | Phase 4 | Recruiting | University of Baghdad | 60 | 2025-07-22 | 2025-08-07 |
| The Effectiveness of CBD and CBN in the Treatment of Facial Pain and Headache of Muscular Origin An aqueous solution containing CBD and CBN, The aqueous solution of placebo - Myalgia, Muscle Pain | Phase 2 / Phase 3 | Enrolling by invitation | Wroclaw Medical University | 42 | 2025-04-01 | 2026-03-06 |
| Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin Blood CB1, CB2, TRPV-1 concentration measurement - Myalgia, Muscle Pain | Enrolling by invitation | Wroclaw Medical University | 102 | 2025-04-01 | 2026-03-06 | |
| Telemonitoring for TMD-Related Pain Structured Telemonitoring, Conservative Management - Temporomandibular Disorders (TMD), Orofacial Pain | Not applicable | Completed | University Magna Graecia | 60 | 2025-01-01 | 2026-08-21 |
| Orofacial Pain in Woodwind and Cello Musicians in German Orchestras online questionnaire - Orofacial Pain, Sleep Problems | Completed | University Medical Center Goettingen | 245 | 2024-11-04 | 2025-02-11 | |
| Effects of Manual Therapy and Home Exercise in Bruxism Manual Therapy, Home Exercise - Bruxism, Manual Theapy | Not applicable | Completed | Ankara University | 30 | 2024-05-01 | 2024-09-24 |
| Photobiomodulation Dosimetry s in Patients With Orofacial Pain Photobiomodulation - Orofacial Pain, Tension-Type Headache | Not applicable | Unknown | University of Nove de Julho | 240 | 2023-10-10 | 2023-10-04 |
| CBD (Cannabidiol) Intraoral Application and TMD (Temporomandibular Disorders) 5% polymer gel with CBD application, 10% polymer gel with CBD application, Placebo intervention - Temporomandibular Disorder, Myofascial Pain | Phase 2 / Phase 3 | Unknown | Medical University of Silesia | 30 | 2023-07-18 | 2023-07-21 |
Showing 20 of 45. Sign in to see all of them.
Facial Pain (45) · Temporomandibular Joint Disorders (12) · Bruxism (4) · Chronic Pain (4) · Tension-Type Headache (4) · Neuralgia (3) · Bites and Stings (2) · Burning Mouth Syndrome (2) · Fibromyalgia (2) · Headache (2) · Myalgia (2) · Temporomandibular Joint Dysfunction Syndrome (2) · Trigeminal Nerve Diseases (2) · Trigeminal Neuralgia (2) · COVID-19 (1)
Neurologic Manifestations (45) · Pathological Conditions, Signs and Symptoms (45) · Signs and Symptoms (45) · Pain (44) · Stomatognathic Diseases (23) · Nervous System Diseases (18) · Musculoskeletal Diseases (16) · Muscular Diseases (15) · Craniomandibular Disorders (13) · Jaw Diseases (13) · Joint Diseases (13) · Mandibular Diseases (13) · Mouth Diseases (8) · Neuromuscular Diseases (8) · Tooth Diseases (7)
Occlusal Adjustment (3) · Musculoskeletal Manipulations (2) · Physical Therapy Modalities (2) · Surveys and Questionnaires (2) · Transcranial Direct Current Stimulation (2) · Transcranial Magnetic Stimulation (2) · Cannabinol (1) · Chlorzoxazone (1) · Conservative Treatment (1) · Dental Care (1) · Diclofenac (1) · Low-Level Light Therapy (1) · Mindfulness-Based Stress Reduction (1) · Occlusal Splints (1) · Orphenadrine (1)
University Medical Center Goettingen (3) · Assistance Publique - Hôpitaux de Paris (2) · UConn Health (2) · University of Nove de Julho (2) · Wroclaw Medical University (2) · Al-Azhar University (1) · Ankara University (1) · Assiut University (1) · Associação Pan-Americana Multidisciplinar de Endocanabinologia (1) · Charles University, Czech Republic (1) · Croatian Science Foundation (1) · Egas Moniz - Cooperativa de Ensino Superior, CRL (1) · Federal University of São Paulo (1) · Fundació Universitària del Bages (1) · Heidelberg University (1)
Germany (5) · United States (5) · Brazil (3) · Poland (3) · Spain (3) · France (2) · Italy (2) · Belgium (1) · Canada (1) · China (1) · Croatia (1) · Denmark (1) · Egypt (1) · Hong Kong (1) · Hungary (1)
Alit Stark Inbar, PhD (1) · Dylan Henssen, MD (1) · Felix Marschner, Dr, MSc (1) · Halenur Bilir, DDS (1) · Hanefi Kurt, PhD (1) · Ian Boggero, PhD (1) · Ingrid Peroz, PD Dr. (1) · Iva Z Alajbeg (1) · Jitka Fricova, M.D., Ph.D. (1) · Joanna M Zakrzewska (1) · Jozef Buday, M.D., Ph.D. (1) · Julio Morales, Bachelor (1) · Kathleen E Wakeman, M.S. (1)
PMID 19492540, PMID 30122975, PMID 31415654, PMID 32289676, PMID 32533874, PMID 32620810, PMID 32687637, PMID 33045706, PMID 33061557, PMID 33797785, PMID 34062145, PMID 34393199, PMID 35254961, PMID 36401476, PMID 38589630, PMID 38956966, PMID 39064299, PMID 39405292, PMID 40481603, PMID 40835226, PMID 41517391, PMID 42826822
2025 (1), R21DE033502 (1), U01DE028520 (1)