7 completed, 1 recruiting. 5 Phase 4, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 3 | Completed 3 |
Follow Chlorzoxazone: new trials by email Literature Review of Chlorzoxazone trials Research Report on Chlorzoxazone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain Chlorzoxazone, Orphenadrine Citrate - Orofacial Pain, Bruxism | Phase 4 | Recruiting | University of Baghdad | 60 | 2025-07-22 | 2025-08-07 |
| Pharmacokinetic and Bioequivalence Comparison of Baclofen and Chlorzoxazone Administered Individually or Concurrently Baclofen 20 mg Tablet, Chlorzoxazone 500 mg Tablet, Baclofen 20mg tablet and Chlorzoxazone 500 mg tablet - Pharmacokinetics | Phase 1 | Completed | University of Texas Southwestern Medical Center | 19 | 2022-04-27 | 2023-03-31 |
| A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers Nitisinone in Arm A, Tolbutamide, Metoprolol - Drug Drug Interaction | Phase 1 | Completed | Swedish Orphan Biovitrum | 36 | 2017-03-28 | 2017-08-10 |
| Chlorzoxazone in Hip and Knee Arthroplasty chlorzoxazone, Placebo, THA - Osteoarthritis of Hip, Osteoarthritis, Knee | Phase 4 | Completed | Northern Orthopaedic Division, Denmark | 400 | 2015-09-01 | 2019-09-09 |
| Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects CRCHUM-MT cocktail - Type 2 Diabetes | Phase 4 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 73 | 2015-04-01 | 2019-07-23 |
| The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery Placebo, Chlorzoxazone, Morphine - Chlorzoxazone, Postoperative Pain | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 110 | 2013-08-01 | 2015-09-17 |
| Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake Parafon Forte - Alcohol Abuse | Phase 4 | Completed | University of California, San Francisco | 48 | 2011-04-01 | 2020-11-20 |
| Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam - Cytochrome, Pharmacokinetics | Phase 1 | Completed | University Hospital, Basel, Switzerland | 16 | 2010-07-01 | 2015-04-17 |
Alcoholism (1) · Bruxism (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Facial Pain (1) · Osteoarthritis (1) · Osteoarthritis, Hip (1) · Osteoarthritis, Knee (1) · Pain, Postoperative (1)
Centre hospitalier de l'Université de Montréal (CHUM) (1) · Copenhagen University Hospital, Rigshospitalet (1) · Northern Orthopaedic Division, Denmark (1) · Swedish Orphan Biovitrum (1) · University Hospital, Basel, Switzerland (1) · University of Baghdad (1) · University of California, San Francisco (1) · University of Texas Southwestern Medical Center (1)
Denmark (2) · United States (2) · Canada (1) · Germany (1) · Iraq (1) · Switzerland (1)
Howard Fields, PhD (1) · Jean-Louis Chiasson, MD (1) · Manuel Haschke, MD (1) · Mogens Laursen, MD, PhD (1) · Rikke Soennichsen, MD (1) · Veronique Michaud, BPharm, PhD (1) · Vikram Shakkottai, MD, PhD (1)
PMID 19492540, PMID 29439084, PMID 31099895, PMID 33061557, PMID 39064299
2016 (1)