176 completed, 10 unknown, 8 recruiting, 8 terminated. 89 Not applicable, 33 Phase 2, 26 Phase 1, 26 Phase 3, 8 Phase 4.
Follow Opportunistic Infections: new trials by email Literature Review of Opportunistic Infections trials Research Report on Opportunistic Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metagenomic Sequencing Across the Infectious Disease Risk and Care Continuum Infectious Diseases, Immunocompromised Host | Not yet recruiting | Karius, Inc. | 10000 | 2026-10-01 | 2026-09-17 | |
| Liposomal Amphotericin B for Invasive Fungal Disease in Solid Organ Transplant Recipients Liposomal Amphotericin B, Alternative Systemic Antifungal Therapy - Invasive Fungal Infection, Solid Organ Transplantation | Not yet recruiting | Sichuan Provincial People's Hospital | 120 | 2026-07-01 | 2026-06-24 | |
| Efficacy and Safety of Immune Checkpoint Inhibitors for Refractory Opportunistic Infections in AIDS Sintilimab - HIV, AIDS | Phase 1 / Phase 2 | Not yet recruiting | Shanghai Public Health Clinical Center | 50 | 2026-05-01 | 2026-05-12 |
| Real-world Cohort Study of Antiretroviral Therapy in HIV Patients With Opportunistic Infections Opportunistic Infections, HIV Related | Not yet recruiting | Shanghai Public Health Clinical Center | 8000 | 2026-05-01 | 2026-04-13 | |
| Enhanced Treatment Strategy for Disseminated MAC Infection in HIV Patients: A Randomized Controlled Trial Standard Triple Therapy, Experimental: Standard Triple Therapy Plus Fluoroquinolone - Opportunistic Infections, HIV Related, Disseminated Mycobacterium Avium Complex Infection | Not applicable | Not yet recruiting | Shanghai Public Health Clinical Center | 124 | 2026-04-30 | 2026-05-13 |
| A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia Recombinant human interleukin (IL) 7-hyFc - Idiopathic CD4 Lymphopenia | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 60 | 2024-11-06 | 2026-10-19 |
| Brain Abscesses in Transplant Recipients: a Multicentre Retrospective Study (BAT-STUDY) Retrospective follow-up - Brain Abscess | Unknown | Assistance Publique - Hôpitaux de Paris | 200 | 2024-02-01 | 2024-02-05 | |
| Re-engagement at Discharge 2 Community Health Worker Post-Discharge Intervention - HIV/AIDS, Hospitalization | Not applicable | Completed | University of Maryland, Baltimore | 97 | 2023-08-18 | 2025-08-07 |
| Early Versus Conventional Cessation of Hydrocortisone in Septic Shock normal saline solution, Hydrocortisone and normal saline solution - Septic Shock, Adverse Event | Phase 2 | Unknown | Mahidol University | 160 | 2023-07-05 | 2024-04-05 |
| Management and Short Term Outcome of Traumatic Wounds in the Emergency Department Wound Heal | Completed | University of Monastir | 3000 | 2022-08-08 | 2026-07-15 | |
| Evaluation of Reporting of Antibody-Drug Conjugate Associated Sepsis-related Toxicities Antibody-Drug Conjugate, Antineoplastic and immunomodulating agents other than Antibody-Drug Conjugate - Sepsis (SMQ), Opportunistic Infections | Completed | Central South University | 24618 | 2022-04-22 | 2022-06-22 | |
| The Diagnosis of Superinfections in Mechanically Ventilated Covid-19 Patients Bronchoalveolar lavage fluid diagnostics - COVID-19 Pneumonia, Superinfection | Unknown | Brno University Hospital | 150 | 2021-12-11 | 2021-12-27 | |
| Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi Enhanced package for AHD care - Opportunistic Infections, HIV-Related, Cryptococcal Infections | Not applicable | Completed | Elizabeth Glaser Pediatric AIDS Foundation | 700 | 2021-06-01 | 2026-09-10 |
| Making an Early Diagnosis of Talaromycosis Using a Novel Antigen Test AIDS/HIV - RelatedDisease Associated With AIDS | Completed | Duke University | 1411 | 2021-02-22 | 2025-02-07 | |
| Inflammation and Co-Infections in D²EFT NRTIs, Darunavir, Ritonavir - HIV-infection/Aids, Human Herpesvirus 4 Infections | Phase 4 | Withdrawn | Kirby Institute | 2021-02-01 | 2020-11-10 | |
| Superinfection and Hyperinflammatory Phenotype in COVID-19 (Coronavirus Disease 2019) Pneumonia Patients Inflammatory markers sampling - COVID-19 Pneumonia, Superinfection Lung | Unknown | Brno University Hospital | 300 | 2020-12-21 | 2022-06-30 | |
| Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity Busulfan test dose, Fludarabine, Busulfan - Lymphoproliferative Disorders, Autoimmune Lymphoproliferative | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2020-09-22 | 2026-10-19 |
| Point-of Care Ultrasound for Patients With HIV Opportunistic infection Ultrasound (OpUS) screening - HIV/AIDS, Opportunistic Infections, HIV Related | Not applicable | Completed | Erasmus Medical Center | 34 | 2020-07-01 | 2022-12-20 |
| T Cell Therapy of Opportunistic Cytomegalovirus Infection CMV specific adoptive t-cells - Cytomegalovirus Infections, Hematopoietic Stem Cell Transplant | Early Phase 1 | Recruiting | Mari Dallas | 20 | 2020-05-27 | 2025-10-22 |
| Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells CMV-specific T-cells - CMV Infection, Cytomegalovirus Infections | Phase 1 | Terminated | University of Wisconsin, Madison | 3 | 2020-02-06 | 2024-10-31 |
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AIDS-Related Opportunistic Infections (167) · HIV Infections (167) · Acquired Immunodeficiency Syndrome (130) · Pneumonia, Pneumocystis (31) · Cytomegalovirus Infections (28) · Cytomegalovirus Retinitis (26) · Multiple Acyl Coenzyme A Dehydrogenase Deficiency (20) · AIDS-Related Complex (18) · Cryptococcosis (18) · Meningitis, Cryptococcal (18) · Retinitis (17) · Meningitis (16) · Mycobacterium avium-intracellulare Infection (15) · Tuberculosis (15)
Infections (213) · Immune System Diseases (188) · Virus Diseases (185) · Immunologic Deficiency Syndromes (184) · RNA Virus Infections (182) · Blood-Borne Infections (180) · Communicable Diseases (180) · Lentivirus Infections (180) · Retroviridae Infections (180) · Urogenital Diseases (177) · Genital Diseases (176) · Sexually Transmitted Diseases (176) · Sexually Transmitted Diseases, Viral (176) · Slow Virus Diseases (134)
Fluconazole (22) · Zidovudine (19) · Ganciclovir (16) · Pentamidine (16) · Foscarnet (12) · Trimethoprim, Sulfamethoxazole Drug Combination (12) · Amphotericin B (10) · Isoniazid (9) · Leucovorin (8) · Pyridoxine (7) · Azithromycin (6) · Ethambutol (6) · Nelfinavir (6) · Pyrazinamide (6) · Clarithromycin (5)
National Institute of Allergy and Infectious Diseases (NIAID) (86) · Pfizer (13) · Hoffmann-La Roche (8) · National Cancer Institute (NCI) (6) · Astra USA (5) · Fisons (5) · Agouron Pharmaceuticals (3) · Bristol-Myers Squibb (3) · Glaxo Wellcome (3) · Ionis Pharmaceuticals, Inc. (3) · Schering-Plough (3) · Shanghai Public Health Clinical Center (3) · Abbott (2) · Anderson Clinical Research (2) · Brno University Hospital (2)
United States (171) · Puerto Rico (11) · Canada (10) · South Africa (6) · Thailand (6) · China (4) · Tanzania (4) · Belgium (3) · Germany (3) · Spain (3) · Czechia (2) · France (2) · India (2) · Malawi (2) · Netherlands (2)
Dimana Dimitrova, M.D. (3) · Gordin F (3) · Armstrong D (2) · B Montgomery (2) · Benson C (2) · Chaisson R (2) · David Perlman (2) · Diane Havlir (2) · El-Sadr W (2) · Feinberg J (2) · Fischl M (2) · Irini Sereti, M.D. (2) · Jacobson M (2) · Judith Currier (2) · LJ Wheat (2)
PMID 20660788, PMID 22219223, PMID 10218526, PMID 10219064, PMID 11172138, PMID 11188837, PMID 12594647, PMID 15470330, PMID 15498605, PMID 15577626, PMID 16131307, PMID 16371882, PMID 17460489, PMID 17943116, PMID 19440326, PMID 19617848, PMID 20181971, PMID 20467286, PMID 20617176, PMID 20942650, PMID 20961563, PMID 21126955, PMID 21293986, PMID 21716078, PMID 22010915, PMID 22126419, PMID 22153000, PMID 22448211, PMID 22473366, PMID 22487689, PMID 22611389, PMID 22639551, PMID 22701801, PMID 22913682, PMID 22944873, PMID 22966426, PMID 23316226, PMID 23485767, PMID 23755215, PMID 23802091, PMID 23935613, PMID 23997952, PMID 24028937, PMID 24052877, PMID 24069604, PMID 24163804, PMID 24175292, PMID 24275116, PMID 24288689, PMID 24326304
2005 (1), U01AI068636 (1), U01AI125003 (1)