20 completed, 3 withdrawn, 1 not yet recruiting, 1 recruiting. 26 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 26 | Completed 20, Withdrawn 3, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 2, Not yet recruiting 1, Recruiting 1 |
Follow Opportunistic Infections: new trials by email Literature Review of Opportunistic Infections trials Research Report on Opportunistic Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Immune Checkpoint Inhibitors for Refractory Opportunistic Infections in AIDS Sintilimab - HIV, AIDS | Phase 1 / Phase 2 | Not yet recruiting | Shanghai Public Health Clinical Center | 50 | 2026-05-01 | 2026-05-12 |
| A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia Recombinant human interleukin (IL) 7-hyFc - Idiopathic CD4 Lymphopenia | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 60 | 2024-11-06 | 2026-10-19 |
| Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells CMV-specific T-cells - CMV Infection, Cytomegalovirus Infections | Phase 1 | Terminated | University of Wisconsin, Madison | 3 | 2020-02-06 | 2024-10-31 |
| Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation CD45RA-depleted peripheral blood mononuclear cells - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute | Phase 1 / Phase 2 | Completed | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 30 | 2014-08-01 | 2016-04-22 |
| The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis Lobradimil, Amphotericin B - Meningitis, Cryptococcal, HIV Infections | Phase 1 | Completed | Alkermes, Inc. | 2005-06-24 | ||
| Effectiveness of Anti-HIV Therapy (HAART) in HIV-Infected Patients With Tuberculosis Nelfinavir mesylate, Ethambutol hydrochloride, Isoniazid - HIV Infections, Tuberculosis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 44 | 2008-09-11 | |
| A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS Itraconazole - HIV Infections, Histoplasmosis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2021-11-01 | |
| Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency Syndrome Foscarnet sodium - Cytomegalovirus Retinitis, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 53 | 2021-11-03 | |
| A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy Ganciclovir - Cytomegalovirus Retinitis, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 38 | 2021-10-27 | |
| A Randomized, Phase I/II Trial to Assess the Safety and Antiviral Effects of Escalating Doses of A Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Viremia and/or Viruria Sevirumab - Cytomegalovirus Infections, HIV Infections | Phase 1 | Completed | Sandoz | 2005-06-24 | ||
| Placebo-Controlled Trial of Safety and Efficacy of Thalidomide in Patients With Infections Due to Mycobacterium and/or HIV Thalidomide - Mycobacterium Avium-Intracellulare Infection, HIV Infections | Phase 1 | Completed | Aaron Diamond AIDS Research Center | 2005-06-24 | ||
| A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir Ganciclovir - Cytomegalovirus Retinitis, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2021-11-03 | |
| A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With Ganciclovir Foscarnet sodium, Ganciclovir - Cytomegalovirus Retinitis, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2021-11-04 | |
| The Safety and Effectiveness of Clarithromycin Plus Zidovudine or Dideoxyinosine in the Treatment of Mycobacterium Avium Complex (MAC) Infections in Children With AIDS Clarithromycin, Zidovudine, Didanosine - Mycobacterium Avium-intracellulare Infection, HIV Infections | Phase 1 | Completed | Abbott | 24 | 2008-08-04 | |
| A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin Isoniazid, Pyridoxine hydrochloride, Levofloxacin - HIV Infections, Tuberculosis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 44 | 2008-08-08 | |
| A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 50 | 2021-11-04 | |
| A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease Cidofovir, Probenecid - Cytomegalovirus Infections, Cytomegalovirus Retinitis | Phase 1 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-10-29 | ||
| Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites Clarithromycin, Rifabutin, Sulfamethoxazole-Trimethoprim - Bacterial Infections, Mycoses | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2021-10-29 | |
| The Safety and Effectiveness of a Two-Drug Combination in the Treatment of Patients With Hepatitis C Plus Advanced HIV Infections Interferon alfa-2b, Zidovudine, Zalcitabine - HIV Infections, Hepatitis C | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 10 | 2012-04-30 | |
| The Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients Cidofovir - HIV Infections, Condyloma Acuminata | Phase 1 | Completed | Gilead Sciences | 40 | 2005-06-24 |
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AIDS-Related Opportunistic Infections (22) · HIV Infections (22) · Acquired Immunodeficiency Syndrome (18) · Cytomegalovirus Infections (8) · Cytomegalovirus Retinitis (5) · AIDS-Related Complex (4) · Multiple Acyl Coenzyme A Dehydrogenase Deficiency (4) · Retinitis (4) · Tuberculosis (3) · Cryptosporidiosis (2) · Meningitis (2) · Meningitis, Cryptococcal (2) · Mycobacterium avium-intracellulare Infection (2) · Pneumonia, Pneumocystis (2)
Infections (26) · Immune System Diseases (25) · Immunologic Deficiency Syndromes (24) · Virus Diseases (24) · Blood-Borne Infections (23) · Communicable Diseases (23) · Genital Diseases (23) · Lentivirus Infections (23) · RNA Virus Infections (23) · Retroviridae Infections (23) · Sexually Transmitted Diseases (23) · Sexually Transmitted Diseases, Viral (23) · Urogenital Diseases (23) · Slow Virus Diseases (18)
Ganciclovir (4) · Foscarnet (3) · Zidovudine (3) · Cidofovir (2) · Clarithromycin (2) · Didanosine (2) · Isoniazid (2) · Rifabutin (2) · Amphotericin B (1) · Dapsone (1) · Ethambutol (1) · Fluconazole (1) · Interferon alpha-2 (1) · Itraconazole (1) · Lamivudine (1)
National Institute of Allergy and Infectious Diseases (NIAID) (17) · Aaron Diamond AIDS Research Center (1) · Abbott (1) · Alkermes, Inc. (1) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · Gilead Sciences (1) · Rhone-Poulenc Rorer (1) · Sandoz (1) · Shanghai Public Health Clinical Center (1) · University of Wisconsin, Madison (1)
United States (20) · China (1) · Russia (1) · South Africa (1) · Thailand (1)
Andrea Lisco, M.D. (1) · B Montgomery (1) · Bryson Y (1) · Christain Capitini, MD (1) · Clifford D (1) · Cohn J (1) · Constance Benson (1) · Dankner W (1) · Diane Havlir (1) · ER Stiehm (1) · Egorin M (1) · Eyster ME (1) · Gershon A (1) · Gill JC (1) · Hafner R (1)