44 completed, 10 withdrawn, 7 terminated, 7 unknown. 24 Phase 3, 20 Phase 2, 15 Not applicable, 11 Phase 1, 7 Phase 4.
Follow Pyridoxine: new trials by email Literature Review of Pyridoxine trials Research Report on Pyridoxine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM Rifampicin, Azithromycin, Isoniazid - Severe Acute Malnutrition, HIV | Phase 3 | Completed | Queen Mary University of London | 674 | 2024-07-15 | 2026-08-25 |
| Pharmacokinetics and Bioequivalence of Doxylamine+Pyridoxine and Diclectin Under Fed Conditions in Healthy Volunteers Doxylamine + Pyridoxine, Diclectin - Nausea | Phase 1 | Completed | Valenta Pharm JSC | 28 | 2024-02-27 | 2025-07-11 |
| The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics Metoclopramide and Vitamin B6, Vitamin B6, Ondansetron - Vomiting | Phase 2 / Phase 3 | Completed | University of Baghdad | 250 | 2024-01-30 | 2024-04-30 |
| Nitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of Labor isosorbide mononitrate, Placebos - Induction of Labor Affected Fetus / Newborn | Phase 4 | Completed | ahmed nagy shaker ramadan | 160 | 2023-12-01 | 2024-08-22 |
| Short Course Low Dose Oral Colchicine After ST Elevation Myocardial Infarction(STEMI) Oral Colchicine 0.6 mg, Oral Pyridoxine 10 mg - STEMI | Phase 4 | Unknown | National University of Malaysia | 64 | 2023-07-28 | 2023-08-31 |
| Effect of Pyridoxine as Add-on Therapy in OCD Patients Pyridoxine, Placebo - OCD | Not applicable | Unknown | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 76 | 2023-06-03 | 2024-02-06 |
| Safety of Administering Isoniazid to SLE Patients to Prevent TB Isoniazid/Pyridoxine, Saccharum Lactis - Tuberculosis, Systemic Lupus Erythematosus | Phase 2 / Phase 3 | Unknown | Universitas Padjadjaran | 60 | 2022-08-15 | 2024-10-01 |
| Role of Neutrophils and Electro-bioluminescence in the Rehabilitation sodium nucleinate - Nonsmall-cell Lung Cancer | Phase 1 | Completed | MIPO Clinic | 34 | 2022-05-01 | 2024-01-17 |
| Lactation Inhibition, the Efficiency of Vitamin B6 Versus Cabergoline Cabergoline, Pyridoxine - Lactation Suppressed | Not applicable | Completed | HaEmek Medical Center, Israel | 89 | 2021-12-31 | 2022-11-14 |
| Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals Dolutegravir (DTG), Isoniazid (INH), Rifapentine (RPT) - HIV Infection, LTBI | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 37 | 2021-02-27 | 2024-09-19 |
| Effect of Pyridoxine on Behavioral Adverse Events of Levetiracetam Pyridoxine, Placebo - Epilepsy, Pyridoxine | Phase 4 | Completed | Nasim Tabrizi | 30 | 2020-10-01 | 2022-03-29 |
| Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics Pyridoxine, Cobalamin, Placebo Oral Tablet - Schizophrenia, Drug Induced Movement Disorder, Unspecified | Phase 2 / Phase 3 | Unknown | Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara | 45 | 2019-09-03 | 2019-12-18 |
| Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals Isoniazid/Rifapentine daily (4 weeks) plus pyridoxine (vitamin B6), Isoniazid/Rifapentine 12-weekly plus pyridoxine (vitamin B6) - HIV-infected Participants With Latent TB Infection in High TB Burden Country | Phase 3 | Active not recruiting | The HIV Netherlands Australia Thailand Research Collaboration | 2500 | 2019-08-15 | 2026-09-16 |
| Video Based Directly Observed Therapy for Latent TB Rifapentine 600 mg orally, Isoniazid 900 mg orally, Pyridoxine 50 mg orally - Latent Tuberculosis | Withdrawn | St. Louis University | 2019-06-30 | 2019-07-01 | ||
| Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients Delamanid (DLM), Isoniazid (INH), Pyridoxine (vitamin B6) - Tuberculosis, MDR | Phase 3 | Active not recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 5832 | 2019-06-03 | 2025-06-15 |
| A Study to Investigate Differences in the Extent and Rate of Absorption of Doxylamine/Pyridoxine From 2 Different Products Under Fasting Conditions doxylamine succinate 10 mg/pyridoxine hydrochloride 10 mg combination, Diclegis (Registered Trademark) - Bioavailability | Phase 1 | Withdrawn | Grünenthal GmbH | 2019-06-01 | 2019-07-11 | |
| Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults Adenosine Triphosphate, Acetylcholine, Sodium Nitroprusside - Receptor Blockade | Early Phase 1 | Completed | Colorado State University | 9 | 2019-02-07 | 2021-07-27 |
| Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes isosorbide mononitrate, Placebo - Induction of Labor Affected Fetus / Newborn, Rupture of Membranes Prior to Onset of Labor | Phase 3 | Completed | ahmed nagy shaker ramadan | 140 | 2018-08-01 | 2020-06-23 |
| Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA) Tenofovir alafenamide, Rifapentine, Isoniazid (INH) - Healthy Volunteers | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 51 | 2018-06-12 | 2024-08-13 |
| Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients Injection Mecobalamin, Tablet Pyridoxine hydrochlorid, Normal saline - Vincristine Induced Neurotoxicity, Acute Lymphoblastic Leukaemia | Phase 2 / Phase 3 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 40 | 2018-03-29 | 2020-07-08 |
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Tuberculosis (15) · HIV Infections (10) · Acquired Immunodeficiency Syndrome (9) · AIDS-Related Opportunistic Infections (7) · Hand-Foot Syndrome (4) · Lymphoma (4) · Schizophrenia (4) · Tuberculosis, Pulmonary (4) · Breast Neoplasms (3) · Colorectal Neoplasms (3) · Stroke (3) · AIDS-Related Complex (2) · Breast Neoplasms, Male (2) · Drug-Related Side Effects and Adverse Reactions (2) · Epilepsy (2)
National Institute of Allergy and Infectious Diseases (NIAID) (11) · M.D. Anderson Cancer Center (5) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (2) · Beersheva Mental Health Center (2) · Centers for Disease Control and Prevention (2) · National Institutes of Health Clinical Center (CC) (2) · ahmed nagy shaker ramadan (2) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (1) · Alliance for Clinical Trials in Oncology (1) · Asan Medical Center (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Casa de Saúde santa Marcelina (1) · Case Comprehensive Cancer Center (1) · Colorado State University (1) · Cook County Health (1)
United States (27) · Haiti (5) · Kenya (5) · South Africa (5) · Thailand (5) · Zimbabwe (5) · Brazil (4) · Uganda (4) · Botswana (3) · India (3) · Israel (3) · Malawi (3) · Peru (3) · Bangladesh (2) · Egypt (2)
Yago Nieto, MD, PHD (4) · Gordin F (2) · Joseph A Kovacs, M.D. (2) · Susan Swindells, MBBS (2) · Ahmed N Shaker, MD (1) · Alice P Chen, M.D. (1) · Amita Gupta, MD, MHS (1) · Anchalee Avihingsanon, MD, PhD (1) · Anneke Hesseling, MD, PhD (1) · Anthony Podany, PharmD (1) · Arai Tolemisova, PhD (1) · Benson C (1) · Brody Holohan, PhD (1) · Brown LS (1) · Chaisson R (1)
PMID 10069782, PMID 10367822, PMID 10529901, PMID 10946791, PMID 11339434, PMID 12324494, PMID 12507972, PMID 14616423, PMID 14699020, PMID 15321804, PMID 15910853, PMID 16543037, PMID 16613998, PMID 16960155, PMID 17645592, PMID 18070815, PMID 18419884, PMID 18510727, PMID 18620104, PMID 18714059, PMID 19125808, PMID 19270033, PMID 19318599, PMID 19416039, PMID 19549699, PMID 19656705, PMID 20484456, PMID 20494665, PMID 20564068, PMID 20625131, PMID 20843504, PMID 21046171, PMID 21060036, PMID 21310866, PMID 21864249, PMID 21877144, PMID 22150035, PMID 22650964, PMID 22972538, PMID 23697526, PMID 23734218, PMID 23936148, PMID 24103380, PMID 24438922, PMID 24647388, PMID 24885137, PMID 25052410, PMID 25770690, PMID 25884778, PMID 25904367
2015 (1), P30CA043703 (1), U01AI068636 (1), U10CA032102 (1)