25 completed, 2 unknown, 2 withdrawn, 1 active not recruiting. 7 Phase 1, 6 Not applicable, 6 Phase 3, 5 Phase 2, 5 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 6, Withdrawn 1 |
| Not applicable | 6 | Completed 5, Unknown 1 |
| Phase 3 | 6 | Completed 6 |
| Phase 2 | 5 | Completed 3, Unknown 1, Withdrawn 1 |
| Phase 4 | 5 | Completed 5 |
Follow Foscarnet: new trials by email Literature Review of Foscarnet trials Research Report on Foscarnet
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects Pritelivir, Investigator's choice - HSV Infection | Phase 3 | Completed | AiCuris Anti-infective Cures AG | 158 | 2017-05-08 | 2026-06-12 |
| Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment With Ganciclovir, Valganciclovir, Foscarnet, or Cidofovir Maribavir, Ganciclovir, Valganciclovir - Cytomegalovirus (CMV) | Phase 3 | Completed | Shire | 352 | 2016-12-22 | 2021-11-03 |
| CMV-CTL for the Treatment of CMV Infection After HSCT donor derived cytomegalovirus specific T lymphocytes, Foscarnet, Ganciclovir - Cytomegalovirus Infections, Hematological Disease | Phase 4 | Completed | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 5 | 2016-11-01 | 2023-04-25 |
| Efficacy and Safety of Foscarnet Sodium and Sodium Chloride Injection in Patients With Herpes Zoster Foscarnet Sodium, Acyclovir - Herpes Zoster | Phase 4 | Completed | Cttq | 94 | 2014-05-01 | 2021-06-28 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| T-Lymphocyte Infusion or Standard Therapy in Treating Patients at Risk of Cytomegalovirus Infection After a Donor Stem Cell Transplant adoptive immunotherapy, alemtuzumab, in vitro-treated peripheral blood lymphocyte therapy - Graft Versus Host Disease, Nonneoplastic Condition | Phase 2 | Unknown | University Hospital Birmingham | 78 | 2009-09-01 | 2013-08-26 |
| Determining a Viral Load Threshold for Treating Cytomegalovirus (CMV) ganciclovir (start when CMV PCR >200copies / ml x2), Monitor (Treatment starts when CMV PCR >3,000 copies / ml), Stop treatment when 2 levels CMV PCR <3,000 copies / ml - Viraemia | Phase 4 | Completed | University College, London | 165 | 2003-02-01 | 2017-10-27 |
| Studies of the Ocular Complications of AIDS (SOCA)--Cytomegalovirus Retinitis Retreatment Trial (CRRT) Ganciclovir, Foscarnet - HIV Infections, Acquired Immunodeficiency Syndrome | Phase 3 | Completed | Johns Hopkins Bloomberg School of Public Health | 279 | 1992-12-01 | 2015-09-14 |
| Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT) Foscarnet, Ganciclovir - HIV Infections, Cytomegalovirus Retinitis | Phase 3 | Completed | Johns Hopkins Bloomberg School of Public Health | 234 | 1990-03-01 | 2015-10-22 |
| The Effect of Stomach Acid on Foscarnet Ranitidine hydrochloride, Foscarnet sodium - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 6 | 2021-10-29 | |
| An Open Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired Immunodeficiency Syndrome and Other Immunodeficiencies Foscarnet sodium - Herpes Simplex, HIV Infections | Not applicable | Completed | Astra USA | 2005-06-24 | ||
| A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use Ganciclovir Foscarnet sodium - Cytomegalovirus Retinitis, HIV Infections | Phase 2 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-11-04 | ||
| The Pilot Study of Foscarnet Cream in the Treatment of Mucocutaneous Herpes Simplex Virus Infections in Immunocompromised Patients Unresponsive to Acyclovir Treatment Foscarnet sodium - Herpes Simplex, HIV Infections | Phase 1 | Completed | Astra USA | 12 | 2005-06-24 | |
| Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot Study Magnesium sulfate, Foscarnet sodium - Cytomegalovirus Infections, HIV Infections | Phase 4 | Completed | Astra USA | 12 | 2005-06-24 | |
| Phase III Multicenter, Open-Label, Randomized Trial of Induction Versus Induction Plus Maintenance Foscarnet ( Foscavir ) Therapy for Gastrointestinal CMV Disease Foscarnet sodium - HIV Infections, Gastrointestinal Diseases | Phase 3 | Completed | Astra USA | 145 | 2005-06-24 | |
| A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure Foscarnet sodium - Cytomegalovirus Retinitis, HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 156 | 2021-11-03 | |
| A Multicenter Study of Oral Versus Intravenous Hydration in AIDS Patients With CMV Retinitis Treated With Foscavir (Foscarnet Sodium) Foscarnet sodium - Cytomegalovirus Retinitis, HIV Infections | Phase 4 | Completed | Astra USA | 112 | 2005-06-24 | |
| Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency Syndrome Foscarnet sodium - Cytomegalovirus Retinitis, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 53 | 2021-11-03 | |
| Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With Acyclovir Vidarabine, Acyclovir, Foscarnet sodium - Herpes Simplex, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 26 | 2021-11-04 | |
| A Multicenter Study To Determine Foscarnet Dose Response in HIV Infected Patients With PGL and/or Constitutional Disease Foscarnet sodium - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 10 | 2021-11-03 |
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HIV Infections (23) · Acquired Immunodeficiency Syndrome (21) · Cytomegalovirus Infections (16) · Cytomegalovirus Retinitis (13) · AIDS-Related Opportunistic Infections (12) · Retinitis (10) · Multiple Acyl Coenzyme A Dehydrogenase Deficiency (8) · Herpes Simplex (5) · AIDS-Related Complex (2) · Anemia, Aplastic (1) · Blast Crisis (1) · Brain Diseases (1) · Burkitt Lymphoma (1) · Congenital Abnormalities (1) · Encephalitis (1)
National Institute of Allergy and Infectious Diseases (NIAID) (12) · Astra USA (9) · Johns Hopkins Bloomberg School of Public Health (2) · AiCuris Anti-infective Cures AG (1) · City of Hope Medical Center (1) · Cttq (1) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (1) · Shire (1) · University College, London (1) · University Hospital Birmingham (1)
United States (22) · United Kingdom (4) · Australia (2) · Belgium (2) · Canada (2) · China (2) · France (2) · Germany (2) · Italy (2) · Switzerland (2) · Argentina (1) · Austria (1) · Croatia (1) · Denmark (1) · Georgia (1)
Jacobson MA (2) · MA Jacobson (2) · Borucki M (1) · C Crumpacker (1) · CS Crumpacker (1) · Clifford D (1) · Collier AC (1) · Curtis Meinert, PhD (1) · DM Kornhauser (1) · Frederick Chen, MD (1) · Gnann J (1) · Hardy WD (1) · Hirsch MS (1) · Jacobson M (1) · Liping Wan, M.D.，Ph.D. (1)
PMID 15498605, PMID 1646585, PMID 33811823, PMID 34864943, PMID 37506264, PMID 38071422, PMID 38700045, PMID 39613120, PMID 39807668, PMID 40478680, PMID 41384277, PMID 9868672
U10EY008057 (2), 2015 (1), U01AI027668 (1)