16 completed. 16 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 16 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow Muscle Weakness: new trials by email Literature Review of Muscle Weakness trials Research Report on Muscle Weakness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection AXA1125, Placebo - Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection | Phase 2 | Completed | Axcella Health, Inc | 41 | 2021-12-15 | 2022-10-20 |
| Electrical Stimulation for Critically Ill Post-Covid-19 Patients Electrical Stimulation, Electrical Stimulation - Sham - COVID-19, Muscle Atrophy | Phase 2 | Completed | Baylor College of Medicine | 19 | 2021-08-18 | 2023-03-07 |
| Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN) Hesperidin, Placebo - Covid19, Anosmia | Phase 2 | Completed | Montreal Heart Institute | 216 | 2021-02-18 | 2022-04-08 |
| An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency doxecitine and doxribtimine - Thymidine Kinase 2 Deficiency | Phase 2 | Completed | UCB BIOSCIENCES, Inc. | 47 | 2019-07-05 | 2026-09-08 |
| Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome Nicotinamide Riboside (NR) - Cancer, Skin Fibroblasts | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2019-03-25 | 2020-12-08 |
| Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD) GSK2881078, Matching Placebo - Cachexia | Phase 2 | Completed | GlaxoSmithKline | 97 | 2018-02-28 | 2020-07-15 |
| A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT) BIO101, Placebo - Sarcopenia, Gait Disorders in Old Age | Phase 2 | Completed | Biophytis | 233 | 2017-02-07 | 2024-10-01 |
| Effect of PROGRESSive Training and Teststerone in Older Frail Men testosterone, Progressive muscle training - Muscle Weakness | Phase 2 / Phase 3 | Completed | University Hospital, Gentofte, Copenhagen | 192 | 2016-11-01 | 2024-05-29 |
| Once-Daily Oral Dose of BeneFlax to Healthy Older Adults secoisolariciresinol diglucoside, vitamin D - Oxidative Stress, Inflammation | Phase 1 / Phase 2 | Completed | University of Saskatchewan | 32 | 2013-04-01 | 2018-06-14 |
| A Study in Older Participants Who Have Fallen and Have Muscle Weakness LY2495655, Placebo - Muscle Weakness | Phase 2 | Completed | Eli Lilly and Company | 201 | 2012-05-01 | 2018-04-25 |
| Oxidative Stress and Nutritional Supplementation Intervention Study secoisolariciresinol diglucoside - Oxidative Stress, Inflammation | Phase 2 | Completed | University of Saskatchewan | 21 | 2010-10-01 | 2018-10-25 |
| Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms Coenzyme Q10, Placebo - Pain, Weakness | Phase 2 / Phase 3 | Completed | Catherine Buettner | 68 | 2009-12-01 | 2017-01-23 |
| Testosterone Therapy After Hip Fracture in Elderly Women Testosterone gel - Hip Fracture, Testosterone Deficiency | Phase 2 | Completed | Washington University School of Medicine | 15 | 2004-08-01 | 2009-02-04 |
| HORMA: Hormonal Regulators of Muscle and Metabolism in Aging Topical testosterone, Recombinant human growth hormone - Sarcopenia, Muscle Weakness | Phase 2 | Completed | National Institute on Aging (NIA) | 108 | 2002-09-01 | 2009-06-02 |
| The Effect of Exercise on Muscle, Function and Cost in VA Nursing Home Residents participation in low intensity exercise, participation in art and music activities - Muscle Weakness | Phase 2 | Completed | US Department of Veterans Affairs | 120 | 2002-07-01 | 2015-04-07 |
| Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis Infliximab - Dermatomyositis, Polymyositis | Phase 2 | Completed | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 14 | 2002-04-10 | 2019-12-03 |
Pain (4) · Inflammation (3) · COVID-19 (2) · Mitochondrial Diseases (2) · Muscular Atrophy (2) · Myalgia (2) · Sarcopenia (2) · Abdominal Pain (1) · Anosmia (1) · Arthralgia (1) · Asthenia (1) · Cachexia (1) · Chest Pain (1) · Confusion (1)
Muscular Diseases (16) · Musculoskeletal Diseases (16) · Nervous System Diseases (16) · Neurologic Manifestations (16) · Neuromuscular Manifestations (16) · Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (16) · Atrophy (4) · Lung Diseases (4) · Pathological Conditions, Anatomical (4) · Respiratory Tract Diseases (4) · Coronaviridae Infections (3) · Coronavirus Infections (3) · Neuromuscular Diseases (3)
Testosterone (2) · secoisolariciresinol diglucoside (2) · Autogenic Training (1) · Deoxycytidine (1) · Ecdysterone (1) · Electric Stimulation (1) · GSK2881078 (1) · Growth Hormone (1) · Hesperidin (1) · Infliximab (1) · Reproductive Techniques, Assisted (1) · Thymidine (1) · Vitamin D (1) · coenzyme Q10 (1) · landogrozumab (1)
University of Saskatchewan (2) · Axcella Health, Inc (1) · Baylor College of Medicine (1) · Biophytis (1) · Catherine Buettner (1) · Eli Lilly and Company (1) · GlaxoSmithKline (1) · Montreal Heart Institute (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (1) · National Institute on Aging (NIA) (1) · UCB BIOSCIENCES, Inc. (1) · US Department of Veterans Affairs (1) · University Hospital, Gentofte, Copenhagen (1) · Washington University School of Medicine (1)
United States (11) · Canada (3) · Germany (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Belgium (1) · Denmark (1) · France (1) · Israel (1) · Spain (1) · Sweden (1)
Adam I Schiffenbauer, M.D. (1) · Betty Raman, MBBS DPhil FRACP (1) · Catherine Buettner, MD, MPH (1) · Ellen F. Binder, MD (1) · Fred R. Sattler, MD (1) · Jane Alcorn, DVD, PhD (1) · Jennifer Jones, MD, FRCPC (1) · Jocelyn Dupuis, MD (1) · Karsten Overgaard, M.D. (1) · Kerry Mansell, BSP, PharmD (1) · Lilian Thorpe, MD, PhD (1) · Mary M. Grant, BSN MA (1) · Paul M Hwang, M.D. (1)
PMID 28159728, PMID 21543538, PMID 26516121, PMID 28922068, PMID 29174792, PMID 29500160, PMID 33246973, PMID 36283827, PMID 36905161, PMID 37223439, PMID 38641716, PMID 39289825
2017 (1), 2018 (1), 2023 (1), K23AR055664 (1), R01AG018169 (1)