19 completed, 10 unknown, 3 recruiting, 1 active not recruiting. 19 Not applicable, 5 Phase 2, 5 Phase 4, 4 Phase 3, 1 Early Phase 1.
Follow Hesperidin: new trials by email Literature Review of Hesperidin trials Research Report on Hesperidin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Auricular Indwelling Needles Added to Diosmin/Hesperidin for Grade I-II Internal Hemorrhoids With Heat-Toxin Syndrome Auricular Indwelling Needles, Sham Auricular Indwelling Needles, Micronized Purified Flavonoid Fraction (Diosmin and Hesperidin) - Internal Haemorrhoids | Not applicable | Not yet recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 64 | 2026-11-20 | 2026-10-27 |
| Cognitive Effects of Hesperidin in Overweight/Obese Older Adults Hesperidin - Cognitive Dysfunction, Overweight and Obesity | Not applicable | Recruiting | Min Hou | 105 | 2026-02-01 | 2026-08-06 |
| Hesperidin RCT in MS Hesperidin, Placebo - Multiple Sclerosis | Not applicable | Recruiting | Swansea University | 60 | 2026-01-07 | 2026-03-05 |
| Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease combination of diosmin, hesperidin, bromelain, and Ruscus aculeatus (Vesvein Gambe) - Prodromal to Chronic Venous Disease | Not applicable | Completed | Ekalab S.r.l. | 80 | 2025-05-28 | 2026-05-22 |
| Silymarin vs Hesperidin/Diosmin in Fibromyalgia Silymarin (LEGALON), Diosmin / Hesperidin (Daflon), no intervention (control group) - Fibromyalgia (FM) | Not applicable | Recruiting | Ain Shams University | 90 | 2024-11-16 | 2025-12-19 |
| EFFECT OF DAFLON (DIOSMIN AND HESPERIDIN) ON POST-OPERATIVE SEROMA FORMATION IN BREAST CANCER SURGERY'' Daflon (Diosmin and Hesperidin) - Post-operative Seroma Formation, Breast Cancer Surgery | Phase 4 | Completed | Ittefaq Hospital trust | 190 | 2024-10-01 | 2026-05-15 |
| Dietary Supplementation and Cognitive Functions in the Elderly Dietary supplement with micronised diosmin, hesperidin and herbal extracts - Cognitive Impairment, Old Age; Debility | Not applicable | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 36 | 2024-05-02 | 2025-03-27 |
| Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery Micronized purified flavonoid fraction(Daflon 1000mg), Placebo - Anal Fistula | Phase 4 | Completed | Taipei Medical University Shuang Ho Hospital | 106 | 2023-12-13 | 2025-05-16 |
| Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins "Venarus®" (diosmin and hesperidin), Endovenous laser ablation (EVLA) with miniphlebectomy, Elastic compression - Varicose Veins of Lower Limb, Varix | Not applicable | Active not recruiting | Ryazan State Medical University | 100 | 2023-04-01 | 2025-07-23 |
| Clinical and Histological Evaluation of Hesperidin as a Direct Pulp Capping Material Hesperidin, Mineral Trioxide Aggregate (MTA) - Pulp Exposure, Dental, Dental Pulp Capping | Not applicable | Completed | Cairo University | 32 | 2022-09-01 | 2024-05-07 |
| Influence of Hesperidin and Vitamin C on Uric Acid Concentration Control, Hesperidin, Vitamin C - Higher Uric Acid Concentrations (>5,5 mg/dl), Healthy | Not applicable | Completed | University of Kiel | 40 | 2022-07-15 | 2023-07-03 |
| Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy Loratadine, Diosmin/ Hesperidin - Vinca Alkaloid Adverse Reaction | Phase 3 | Unknown | Ain Shams University | 90 | 2022-03-01 | 2022-02-17 |
| Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product Diosmin/Hesperidin (90/10) 500 mg Test Drug, Diosmin/Hesperidin (90/10) 500 mg Reference Product - Bioequivalence | Phase 1 | Completed | Laboratorios Andromaco S.A. | 12 | 2021-11-04 | 2022-02-14 |
| Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN) Hesperidin, Placebo - Covid19, Anosmia | Phase 2 | Completed | Montreal Heart Institute | 216 | 2021-02-18 | 2022-04-08 |
| Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome Medtronic® Concerto® detachable coil system, sclerosis, Diosmin / Hesperidin - Pelvic Congestive Syndrome, Pelvic Varices | Phase 4 | Unknown | Hospital de Clínicas Dr. Manuel Quintela | 120 | 2020-10-01 | 2020-04-24 |
| Impact of Treatment With VENARUS® on the Level of Monocyte Chemoattractant Protein 1 in Varicose Veins Blood Diosmin / Hesperidin - Varicose Veins | Not applicable | Completed | Pirogov Russian National Research Medical University | 30 | 2020-09-01 | 2022-03-31 |
| Hesperidin and Diosmin for Treatment of COVID-19 Hesperidin and Diosmin mixture - Coronavirus Infection | Early Phase 1 | Unknown | Tanta University | 100 | 2020-07-01 | 2020-06-30 |
| Bioavailability of Hesperidine and Narirutin From Orange Juice to Identify Metabotypes in Hypertension Orange juice rich in hesperidin and narirutin - Blood Pressure, Hypertension | Not applicable | Completed | Technological Centre of Nutrition and Health, Spain | 67 | 2020-02-24 | 2022-02-28 |
| Lipid Peroxidation and Options Antioxidant Therapy for Secondary Lymphedema of the Lower Extremities Micronised purified flavonoid fraction (diosmin+flavonoids expressed as hesperidin), Tocopherol, Elastic compression - Lower Extremity Lymphedema | Phase 4 | Completed | Ryazan State Medical University | 120 | 2019-09-01 | 2022-08-04 |
| Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists 2S-hesperidin, Placebo - Power, Metabolic Disturbance | Not applicable | Completed | Francisco Javier Martínez Noguera | 40 | 2018-09-22 | 2020-10-23 |
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Metabolic Syndrome (4) · Bone Diseases, Metabolic (3) · Obesity (3) · Osteoporosis (3) · Body Weight Changes (2) · Cognitive Dysfunction (2) · Non-alcoholic Fatty Liver Disease (2) · Varicose Veins (2) · Venous Insufficiency (2) · Abdominal Pain (1) · Acid-Base Imbalance (1) · Anosmia (1) · Arthralgia (1) · COVID-19 (1) · Chest Pain (1)
National Nutrition and Food Technology Institute (5) · Ain Shams University (2) · Ryazan State Medical University (2) · Société des Produits Nestlé (SPN) (2) · Cairo University (1) · Ekalab S.r.l. (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Francisco Javier Martínez Noguera (1) · Fundação Educacional Serra dos Órgãos (1) · Hospital de Clínicas Dr. Manuel Quintela (1) · Ittefaq Hospital trust (1) · Laboratorios Andromaco S.A. (1) · Laboratório Teuto Brasileiro S/A (1) · Maastricht University Medical Center (1) · Min Hou (1)
Iran (5) · Italy (3) · Russia (3) · United States (3) · Egypt (2) · Spain (2) · Brazil (1) · Canada (1) · China (1) · France (1) · Germany (1) · India (1) · Malaysia (1) · Netherlands (1) · Pakistan (1)
Ad Masclee, MD (1) · Anja Bosy-Westphal, Prof, PhD, MD (1) · Berdine R Martin, PhD (1) · Calin Giurcaneanu, MD (1) · Connie M Weaver, Ph.D. (1) · Hayley A Young, PHD (1) · Igor Suchkov (1) · Igor Zolotukhin, PhD (1) · Jocelyn Dupuis, MD (1) · Kashif Munir, MD (1) · Marcio Steinbruch, MD (1) · Marie-Noelle Horcajada, PhD (1) · Renato Kaufman, MD (1)
PMID 21346065, PMID 23638291, PMID 26751193, PMID 31844967, PMID 32531538, PMID 33402222, PMID 33512717, PMID 40694049, PMID 41739218, PMID 41776089