6 completed, 2 recruiting, 1 terminated, 1 unknown. 10 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 6, Recruiting 2, Terminated 1, Unknown 1 |
| Phase 2 | 4 | Completed 2, Recruiting 1, Terminated 1 |
Follow Muscle Weakness: new trials by email Literature Review of Muscle Weakness trials Research Report on Muscle Weakness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy AAV9-Follistatin gene therapy, VEGF Plasmid - Age-related Muscle Decline | Phase 1 / Phase 2 | Recruiting | Unlimited Biotechnology LLC | 12 | 2026-06-01 | 2026-07-13 |
| Study of Anitocabtagene Autoleucel in Participants With Non-Oncology Plasma Cell-Related Diseases anito-cel, Cyclophosphamide, Fludarabine - Muscular Diseases, Neuromuscular Manifestations | Phase 1 | Recruiting | Kite, A Gilead Company | 30 | 2025-04-30 | 2026-10-22 |
| Open-label Study to Evaluate the Safety of Various Dosing Regimens of MuSK-CAART for MuSK Myasthenia Gravis MuSK-CAART - MuSK Myasthenia Gravis | Phase 1 | Completed | Cabaletta Bio | 7 | 2022-11-23 | 2025-11-10 |
| Leg Heat Therapy in Elderly Individuals Sham device, Leg heat therapy device - Aging, Muscle Weakness | Phase 1 | Completed | Purdue University | 24 | 2022-09-05 | 2024-07-10 |
| Electrical Stimulation for Critically Ill Covid-19 Patients Electrical Stimulation, Electrical Stimulation - Sham - Covid19, Muscle Atrophy | Phase 1 | Completed | Baylor College of Medicine | 19 | 2020-12-22 | 2023-02-16 |
| Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome Nicotinamide Riboside (NR) - Cancer, Skin Fibroblasts | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2019-03-25 | 2020-12-08 |
| Evaluating Muscle Weakness Improvement With Lorcaserin in ICU Lorcaserin, Placebo - Muscle Weakness, Sepsis | Phase 1 / Phase 2 | Terminated | Johns Hopkins University | 5 | 2015-12-01 | 2020-01-13 |
| Energetics and Function in Older Humans Cysteine (as n-acetylcysteine) and Glycine - Aging, Erythrocyte Glutathione Deficiency | Phase 1 | Completed | Baylor College of Medicine | 16 | 2014-11-01 | 2022-02-11 |
| Once-Daily Oral Dose of BeneFlax to Healthy Older Adults secoisolariciresinol diglucoside, vitamin D - Oxidative Stress, Inflammation | Phase 1 / Phase 2 | Completed | University of Saskatchewan | 32 | 2013-04-01 | 2018-06-14 |
| Improving Ambulatory Community Access After Paralysis IRS-8 (8 channel implanted receiver stimulator) - Stroke, Partial Paralysis | Phase 1 | Unknown | Louis Stokes VA Medical Center | 6 | 2012-04-01 | 2018-03-14 |
Autoimmune Diseases (2) · Muscular Atrophy (2) · Myasthenia Gravis (2) · Autoimmune Diseases of the Nervous System (1) · COVID-19 (1) · Frailty (1) · Hyperthermia (1) · Immune System Diseases (1) · Inflammation (1) · Muscular Diseases (1) · Musculoskeletal Diseases (1) · Neoplasms (1) · Neuromuscular Diseases (1) · Neuromuscular Manifestations (1)
Nervous System Diseases (10) · Neurologic Manifestations (10) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Muscular Diseases (9) · Musculoskeletal Diseases (9) · Neuromuscular Manifestations (9) · Atrophy (2) · Infections (2) · Neoplasms (2) · Neoplasms by Site (2) · Nervous System Neoplasms (2) · Neurodegenerative Diseases (2) · Neuromuscular Junction Diseases (2)
Cyclophosphamide (1) · Cysteine (1) · Electric Stimulation (1) · Glycine (1) · Vitamin D (1) · fludarabine (1) · lorcaserin (1) · nicotinamide-beta-riboside (1) · secoisolariciresinol diglucoside (1)
Baylor College of Medicine (2) · Cabaletta Bio (1) · Johns Hopkins University (1) · Kite, A Gilead Company (1) · Louis Stokes VA Medical Center (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Purdue University (1) · University of Saskatchewan (1) · Unlimited Biotechnology LLC (1)
United States (8) · Canada (1) · Honduras (1)
Dale M Needham, MD, PhD (1) · Jane Alcorn, DVD, PhD (1) · Jennifer Jones, MD, FRCPC (1) · Kerry Mansell, BSP, PharmD (1) · Lilian Thorpe, MD, PhD (1) · Paul M Hwang, M.D. (1) · R V Sekhar, M.D. (1) · Rudi Kobetic, MSBE (1) · Sharyle Fowler, MD (1) · Susan Whiting, PhD (1) · Thomas Hadjistavropoulos, PhD, RD (1)
PMID 28159728, PMID 28899825, PMID 36561714
I01RX000528 (1), UL1TR001079 (1)