11 completed, 9 recruiting, 7 unknown, 6 not yet recruiting. 19 Not applicable, 3 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Recruiting 6, Completed 5, Not yet recruiting 5, Unknown 2, Active not recruiting 1 |
| Phase 4 | 3 | Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Multivessel Coronary Artery Disease: new trials by email Literature Review of Multivessel Coronary Artery Disease trials Research Report on Multivessel Coronary Artery Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE Renal denervation - Multivessel Coronary Artery Disease, Hypertension Resistant to Conventional Therapy | Not applicable | Not yet recruiting | Ceric Sàrl | 1000 | 2026-11-01 | 2026-05-22 |
| Brazilian Prospective Registry of the Inspiron EVO Drug-Eluting Stent in Complex Coronary Lesions Inspiron EVO Drug-Eluting Stent - Coronary Artery Disease (CAD), Stenosis Coronary | Recruiting | Scitech Produtos Medicos SA | 2000 | 2026-10-30 | 2026-10-02 | |
| The CORE - μFR Clinical Trial Angiography-guided PCI, μFR based-PCI - Acute Coronary Syndromes (ACS), NSTEMI - Non-ST-Segment Elevation Myocardial Infarction | Not applicable | Not yet recruiting | University of Roma La Sapienza | 350 | 2026-05-18 | 2026-05-22 |
| Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL) CABG, PCI - Coronary Artery Disease, Coronary Artery Disease (CAD) | Not applicable | Recruiting | University Medical Center Groningen | 358 | 2026-05-01 | 2026-05-12 |
| For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation. IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR) - Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease | Not yet recruiting | Beijing Anzhen Hospital | 200 | 2025-12-02 | 2025-12-04 | |
| Insights From the FAST-TRACK CABG Trial: a Clinical Outcome Study in Patient With Previous Surgical Revascularization for Complex Three-vessel or Left Main Coronary Artery Disease Based on Coronary Computed Tomography Angiogram, and Fractional Flow Reserve Derived by Computed Tomography Multivessel Coronary Artery Disease | Recruiting | Centro Cardiologico Monzino | 100 | 2025-09-01 | 2026-09-17 | |
| Revascularization Strategies in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) and Severe Coronary Artery Disease PCI, CABG - Multivessel Coronary Artery Disease, Acute Coronary Syndrome | Not applicable | Recruiting | American Heart of Poland | 1000 | 2025-08-25 | 2026-07-08 |
| Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques. Sirolimus drug eluting ballooon therapy, Optimal guidelines-directed medical therapies (GDMT) - Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques | Not applicable | Not yet recruiting | Cardiocentro Ticino | 24 | 2025-04-01 | 2025-04-15 |
| Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina Percutaneous coronary intervention (PCI), Symptom assessment during experimentally induced ischaemia - Stable Angina, Multivessel Coronary Artery Disease | Not applicable | Recruiting | Imperial College London | 50 | 2024-06-13 | 2026-10-28 |
| Robotically-assisted Minimally-invasive Direct Coronary Artery Bypass With Stenting, Randomized Against Coronary Artery Bypass Graft Surgery Coronary Artery Bypass Graft, Robotically-assisted minimally-invasive direct coronary artery bypass, Percutaneous Coronary Intervention - Coronary Artery Disease, Multivessel Coronary Artery Disease | Not applicable | Not yet recruiting | Cardiology Research UBC | 80 | 2024-05-01 | 2024-04-23 |
| STICH3C Cardiac Magnetic Resonance Observational Study Cardiac Magnetic Resonance Imaging - Ischemic Left Ventricle Systolic Dysfunction, Multivessel Coronary Artery Disease | Recruiting | Weill Medical College of Cornell University | 230 | 2024-03-01 | 2026-09-21 | |
| Safety and Effectiveness of GENOSS® DES in Patients With Multivessel Coronary Artery Disease GENOSS® DES Sirolimus Eluting Coronary Stent System - Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease | Enrolling by invitation | Genoss Co., Ltd. | 1000 | 2023-11-15 | 2025-10-06 | |
| Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI Culprit-lesion revascularization, Non-culprit-lesion revascularization - Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease | Not applicable | Recruiting | Leipzig Heart Science gGmbH | 3390 | 2023-10-27 | 2025-01-16 |
| Residual Inflammatory Risk-Guided colcHicine in Elderly Trial colchicine - Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease | Phase 4 | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 800 | 2023-09-01 | 2023-09-06 |
| Complete Revascularization Via Inferior Part-sternotomy Inferior part-sternotomy, Full median sternotomy - Complete Revascularization, Coronary Artery Bypass Grafting | Not applicable | Not yet recruiting | China National Center for Cardiovascular Diseases | 260 | 2023-05-05 | 2023-04-28 |
| Temporary MCS With the iVAC 2L Transaortic Device in High-risk PCI iVAC 2L - Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease | Not applicable | Recruiting | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 100 | 2023-02-17 | 2025-09-08 |
| The FAVOR V AMI Trial FAST Technique, Angiography - ST-Segment Elevation Myocardial Infarction, Multivessel Coronary Artery Disease | Not applicable | Recruiting | China National Center for Cardiovascular Diseases | 5000 | 2023-01-17 | 2026-09-24 |
| Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease | Unknown | Erasmus Medical Center | 111 | 2022-06-22 | 2023-01-26 | |
| Ten-Year Outcomes of Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease coronary stent implantation, bypass grafting - Multivessel Coronary Artery Disease | Completed | Seung-Jung Park | 880 | 2022-05-01 | 2022-08-05 | |
| COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events PCI revascularization strategy based on combined FFR and OCT assessment, PCI revascularization strategy based FFR assessment - Multivessel Coronary Artery Disease, Ischemia | Not applicable | Active not recruiting | Diagram B.V. | 1223 | 2022-03-16 | 2026-06-03 |
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Coronary Artery Disease (7) · ST Elevation Myocardial Infarction (6) · Acute Coronary Syndrome (4) · Angina, Stable (3) · Angina Pectoris (2) · Atherosclerosis (2) · Heart Failure (2) · Myocardial Infarction (2) · Non-ST Elevated Myocardial Infarction (2) · Angina, Unstable (1) · Cardiovascular Diseases (1) · Coronary Stenosis (1) · Death (1) · Dermatopathia pigmentosa reticularis (1) · Heart Diseases (1)
Vascular Diseases (21) · Cardiovascular Diseases (20) · Heart Diseases (20) · Myocardial Ischemia (20) · Pathological Conditions, Signs and Symptoms (16) · Pathologic Processes (12) · Infarction (10) · Ischemia (10) · Necrosis (10) · Arterial Occlusive Diseases (9) · Arteriosclerosis (9) · Myocardial Infarction (8) · Coronary Disease (7) · Chest Pain (4) · Neurologic Manifestations (4)
Percutaneous Coronary Intervention (6) · Coronary Artery Bypass (3) · Angiography (1) · Biomatrix preparation (1) · Colchicine (1) · Coronary Angiography (1) · Stents (1) · Surgical Procedures, Operative (1) · evolocumab (1)
China National Center for Cardiovascular Diseases (2) · ECRI bv (2) · American Heart of Poland (1) · Beijing Anzhen Hospital (1) · Cardiocentro Ticino (1) · Cardiology Research UBC (1) · Catholic University, Italy (1) · Centro Cardiologico Monzino (1) · Ceric Sàrl (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · Diagram B.V. (1) · Erasmus Medical Center (1) · European Hospital (1) · Genoss Co., Ltd. (1) · Hospices Civils de Lyon (1)
China (8) · Italy (7) · Poland (6) · Germany (5) · Netherlands (5) · South Korea (4) · Austria (3) · France (3) · Switzerland (3) · Belgium (2) · Brazil (2) · Canada (2) · Japan (2) · Malaysia (2) · Russia (2)
Alexander Kharlamov, M.D., FESC, FACC, FEACVI (1) · Bo Xu, MBBS (1) · Bon-Kwon Koo, MD (1) · Chang-Wook Nam, Postdoctoral (1) · Dmitry Pevzner, MD (1) · Elmir Omerovic, MD PhD (1) · Elvin Kedhi, Prof.dr. (1) · Erik Lipsic, Dr (1) · Eva Rumiz Gonzalez, MD, PhD (1) · Evgeniy Merkulov, MD (1) · Fabrizio Tomai, MD (1) · Felix Mahfoud, Prof. (1) · Franz-Josef Neumann, MD PhD (1) · Gert Richardt, MD PhD (1) · Hai Gao, MD, PHD (1)
PMID 19924001, PMID 24357403, PMID 25864858, PMID 26347918, PMID 26498666, PMID 27609817, PMID 28304224, PMID 28317428, PMID 28644056, PMID 28862970, PMID 29146670, PMID 29361444, PMID 29449274, PMID 30312411, PMID 30586749, PMID 30813812, PMID 30823897, PMID 31097161, PMID 31268466, PMID 31475795, PMID 31833413, PMID 32914672, PMID 33541105, PMID 33999545, PMID 34736563, PMID 35045732, PMID 36121700, PMID 38743727, PMID 40097279, PMID 40209841, PMID 40368452, PMID 40924133, PMID 41159879, PMID 42276410, PMID 42464287, PMID 42866922
R01HL170566 (1)