11 completed, 2 recruiting, 2 withdrawn, 1 terminated. 8 Not applicable, 3 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 7, Terminated 1 |
| Phase 3 | 3 | Completed 2, Recruiting 1 |
| Phase 4 | 2 | Withdrawn 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Ziltivekimab on Coronary Atherosclerotic Burden in Patients With Acute Myocardial Infarction Ziltivekimab, Placebo - Coronary Artery Disease, Acute Myocardial Infarction (AMI) | Phase 3 | Recruiting | ECRI bv | 332 | 2025-12-19 | 2026-03-23 |
| IVUS CHIP UPP Registry IVUS - Coronary Artery Disease, Coronary Artery Disease Risk High | Recruiting | ECRI bv | 1010 | 2025-09-30 | 2026-09-23 | |
| Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization vFFR guided revascularization, FFR guided revascularization - Coronary Artery Disease | Not applicable | Completed | ECRI bv | 2235 | 2021-11-09 | 2026-06-23 |
| Intravascular Ultrasound Guidance for Complex High-risk Indicated Procedures IVUS, Angio - Complex Coronary Lesions | Not applicable | Completed | ECRI bv | 2020 | 2021-11-02 | 2026-06-23 |
| The OPTIMAL Randomized Controlled Trial IVUS guided Percutaneous Coronary Intervention, Qualitative or quantitative angiography will guide percutaneous coronary intervention - Left Main Coronary Artery Stenosis | Not applicable | Completed | ECRI bv | 806 | 2020-07-08 | 2026-06-23 |
| Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion Evolocumab - Coronary Artery Disease | Phase 4 | Withdrawn | ECRI bv | 2019-08-30 | 2019-12-06 | |
| A Multicentre, Pilot Study to Evaluate the Safety and the Feasibility of Planning and Execution of Surgical Revascularization in Patients With Complex Coronary Artery Disease, Based Solely on MSCT Imaging Utilizing GE Healthcare Revolution CT and HeartFlow FFRCT. Multi-sliced computed tomography (MSCT) - Multivessel Coronary Artery Disease | Phase 4 | Withdrawn | ECRI bv | 2019-06-28 | 2019-12-06 | |
| POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI) BiOSS LIM C - Coronary Stenosis | Not applicable | Terminated | ECRI bv | 130 | 2018-08-10 | 2025-09-15 |
| Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen Aspirin, P2Y12 inhibitor - High Bleeding Risk, Coronary Artery Disease | Not applicable | Completed | ECRI bv | 4579 | 2017-04-04 | 2021-08-20 |
| Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent SUPRAFLEX, XIENCE - Coronary Stenosis | Not applicable | Completed | ECRI bv | 1435 | 2016-10-21 | 2020-12-17 |
| SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease Coronary Angiography, Computed Tomography (CT) scan - Coronary Artery Diseases, Multivessel Coronary Artery Disease | Completed | ECRI bv | 223 | 2016-06-27 | 2019-09-27 | |
| Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) Acetylsalicylic acid, Clopidogrel, Rivaroxaban - Aortic Valve Stenosis, Cardiovascular Diseases | Phase 3 | Completed | ECRI bv | 231 | 2016-05-01 | 2020-01-18 |
| Study Comparing the MiStent SES Versus the XIENCE EES Stent MiStent, XIENCE EES - Coronary Stenosis | Not applicable | Completed | ECRI bv | 1398 | 2015-03-20 | 2023-05-08 |
| Trial Evaluating New Strategy in the Functional Assessment of 3-vessel Disease Using SYNTAXII Score in Patients With PCI Coronary stent, Multi Slice Computed Tomography, instantaneous wave-free ratio - Heart Diseases, Cardiovascular Diseases | Completed | ECRI bv | 454 | 2014-02-06 | 2022-07-21 | |
| ABSORB STEMI: the TROFI II Study Percutaneous Coronary Intervention - Acute ST Segment Elevation Myocardial Infarction | Not applicable | Completed | ECRI bv | 191 | 2014-01-06 | 2018-07-24 |
| GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation Ticagrelor, Acetylsalicylic Acid, Clopidogrel - Coronary Artery Disease (CAD) | Phase 3 | Completed | ECRI bv | 15991 | 2013-07-01 | 2022-03-15 |
Coronary Artery Disease (8) · Cardiovascular Diseases (3) · Coronary Stenosis (3) · Heart Diseases (2) · Aortic Valve Stenosis (1) · Atherosclerosis (1) · Heart Valve Diseases (1) · ST Elevation Myocardial Infarction (1) · Thrombosis (1) · Ventricular Outflow Obstruction (1)
Aspirin (3) · Clopidogrel (2) · Percutaneous Coronary Intervention (1) · Platelet Aggregation Inhibitors (1) · Rivaroxaban (1) · Ticagrelor (1) · Ultrasonography, Interventional (1) · acetylsalicylic acid lysinate (1) · evolocumab (1) · ziltivekimab (1)
Italy (9) · Netherlands (9) · Germany (8) · Spain (8) · France (7) · Switzerland (7) · United Kingdom (7) · Poland (6) · Belgium (5) · Denmark (4) · Bulgaria (3) · Hungary (3) · Australia (2) · Austria (2) · Canada (2)
Ernest Spitzer, MD (6) · Patrick W Serruys, Prof. dr. (2) · A. Zaman, MD. (1) · Adrian Banning, MD (1) · Adrian Banning, Prof (1) · David E Kandzari, MD (1) · E. Spitzer, Dr. (1) · Ernest Spitzer, MD. (1) · Javier Escaned, MD (1) · Joost Daemen, MD, PhD (1) · Luca Testa, Dr. (1) · M. Valgimigli, Prof. (1)
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