3 completed, 3 terminated, 2 active not recruiting, 2 recruiting. 13 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 3, Terminated 3, Active not recruiting 2, Recruiting 2, Unknown 2, Not yet recruiting 1 |
| Phase 2 | 5 | Recruiting 2, Active not recruiting 1, Terminated 1, Unknown 1 |
Follow Mortality: new trials by email Literature Review of Mortality trials Research Report on Mortality
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Minocycline in Stroke Study at Maimonides Minocycline 200mg - Stroke, Ischemia Stroke | Phase 2 / Phase 3 | Recruiting | Joyce Chen | 1164 | 2026-02-02 | 2026-03-19 |
| Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI propranolol, normal saline IV - Traumatic Brain Injury (TBI) Patients, Intracranial Pressure | Phase 3 | Not yet recruiting | Tanta University | 60 | 2025-09-20 | 2025-03-11 |
| Limited Versus Extended Trophic Feeding (LET-FEED) Trial Limited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics) - Sepsis, Length of Stay | Phase 2 / Phase 3 | Recruiting | University of Washington | 350 | 2025-07-03 | 2026-08-17 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia Tablets, Clarithromycin 500mg - Community-acquired Pneumonia, Sepsis | Phase 3 | Completed | Hellenic Institute for the Study of Sepsis | 278 | 2021-01-25 | 2023-12-12 |
| Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali Placebo, Azithromycin - Mortality | Phase 3 | Completed | Tampere University | 149201 | 2020-10-15 | 2025-05-21 |
| Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? Nicotinamide treatment, placebo treatment - Acute Kidney Injury, Septic Shock | Phase 3 | Active not recruiting | Centre Hospitalier Universitaire, Amiens | 310 | 2020-10-01 | 2025-08-24 |
| Human Milk Fortification in Extremely Preterm Infants H2MF, Bovine milk-based fortifier - Necrotizing Enterocolitis, Sepsis | Phase 2 / Phase 3 | Active not recruiting | Thomas Abrahamsson, MD, PhD | 229 | 2019-02-01 | 2024-07-23 |
| Different Surgical Approaches in Patients of Early-stage Cervical Cancer Laparotomic radical hysterectomy, Laparotomic radical trachelectomy, Laparoscopic radical hysterectomy - Uterine Cervical Neoplasm, Laparotomy | Phase 3 | Unknown | Lei Li | 700 | 2018-11-23 | 2018-12-28 |
| Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System Clarithromycin, Water for injection - Sepsis, Pneumonia | Phase 3 | Completed | Hellenic Institute for the Study of Sepsis | 110 | 2017-12-15 | 2020-12-22 |
| Nutritional Intervention Program in Malnourished Patients Admitted for Heart Failure Nutritional intervention - Heart Failure, Malnutrition | Phase 3 | Terminated | Hospital San Juan de la Cruz | 120 | 2012-03-01 | 2015-09-22 |
| Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart-Study) Remote Ischemic Preconditioning, Control/sham procedure (blood pressure cuff) - Myocardial Injury, Mortality | Phase 3 | Terminated | University Hospital Schleswig-Holstein | 1400 | 2010-12-01 | 2015-12-03 |
| Septic Shock em Steroids Hydrocortisone - Mechanical Ventilation, Mortality | Phase 2 / Phase 3 | Unknown | Unidade de Terapia Intensiva | 160 | 2008-05-01 | 2010-01-13 |
Sepsis (5) · Hemorrhagic Stroke (2) · Ischemic Stroke (2) · Stroke (2) · cyclopia sequence (2) · Acute Kidney Injury (1) · Adrenal Insufficiency (1) · Brain Injuries, Traumatic (1) · Cerebral Hemorrhage (1) · Community-Acquired Pneumonia (1) · Enterocolitis, Necrotizing (1) · Gram-Negative Bacterial Infections (1) · Heart Failure (1) · Infections (1) · Inflammation (1)
Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Infections (6) · Inflammation (6) · Systemic Inflammatory Response Syndrome (6) · Brain Diseases (3) · Cardiovascular Diseases (3) · Central Nervous System Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Nervous System Diseases (3) · Urogenital Diseases (3) · Cerebrovascular Disorders (2) · Female Urogenital Diseases (2) · Male Urogenital Diseases (2) · Pregnancy Complications (2)
Clarithromycin (2) · Minocycline (2) · Azithromycin (1) · Control Groups (1) · Hydrocortisone (1) · Injections (1) · Propranolol (1) · Tablets (1) · Water (1)
Hellenic Institute for the Study of Sepsis (2) · Centre Hospitalier Universitaire, Amiens (1) · Hospital San Juan de la Cruz (1) · Joyce Chen (1) · Lei Li (1) · Maimonides Medical Center (1) · Tampere University (1) · Tanta University (1) · Thomas Abrahamsson, MD, PhD (1) · Unidade de Terapia Intensiva (1) · University Hospital Schleswig-Holstein (1) · University of Washington (1)
United States (3) · Greece (2) · Belgium (1) · Brazil (1) · China (1) · Egypt (1) · France (1) · Germany (1) · Mali (1) · Spain (1) · Sweden (1)
Apostolos Armaganidis, MD, PhD (1) · Berthold Bein, MD, DESA (1) · Camilla Ducker, MBBS, MSc (1) · Dagmar Alber, PhD (1) · Evangelos J Giamarellos-Bourboulis, MD, PhD (1) · Gregory C Valentine (1) · Huda Elkallaf, Resident (1) · Jochen Cremer, MD (1) · Kai Zacharowski, MD, PhD (1) · Nigel Klein, MBBS, PhD (1) · Patrick Meybohm, MD (1) · Per Ashorn, MD, PhD (1) · Qingliang T. Wang, MD, PhD (1) · Samba Sow, MD, MSc (1) · Thomas R Abrahamsson, MD, PhD (1)
PMID 10933646, PMID 18444850, PMID 20610825, PMID 22564837, PMID 22880214, PMID 24292991, PMID 25252696, PMID 26436208, PMID 27044546, PMID 28262195, PMID 29581218, PMID 30678657, PMID 31362966, PMID 32502439, PMID 33317612, PMID 34815288, PMID 34931696, PMID 35717241, PMID 36597115, PMID 37968741, PMID 38184008, PMID 38545091, PMID 41092331, PMID 41934919, PMID 42268611, PMID 42623398, PMID 42704050