24 completed, 10 unknown, 5 recruiting, 4 not yet recruiting. 23 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 3, 1 Phase 4.
Follow Minimally Conscious State: new trials by email Literature Review of Minimally Conscious State trials Research Report on Minimally Conscious State
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State | Not applicable | Not yet recruiting | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | 200 | 2026-12-01 | 2026-10-02 |
| Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP) Consciousness Disorders, Persistent Vegetative State | Not yet recruiting | Nicosia General Hospital | 40 | 2026-09-15 | 2026-07-30 | |
| Temporal Interference Stimulation for Disorders of Consciousness Temporal Interference - Disorder of Consciousness, Minimally Conscious State | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Liege | 4 | 2026-09-01 | 2026-10-19 |
| fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Recruiting | University of California, Los Angeles | 55 | 2026-05-01 | 2026-06-08 | |
| Auditory Processing in DOC Patients Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG) - Disorder of Consciousness, Unresponsive Wakefulness Syndrome | Not yet recruiting | BDH-Klinik Hessisch Oldendorf | 42 | 2026-04-15 | 2026-03-06 | |
| Effectiveness of tTIs for Improving Consciousness in Patients With DoC Theta-burst Patterned Temporal Interference Stimulation (tTIs), Sham Temporal Interference Stimulation - Disorders of Consciousness, Vegetative State | Not applicable | Recruiting | Zhujiang Hospital | 136 | 2026-03-08 | 2026-04-20 |
| Assessment of Consciousness With CRS-R and SECONDs Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R) - Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State | Recruiting | BDH-Klinik Hessisch Oldendorf | 110 | 2026-02-01 | 2026-03-11 | |
| Neurological and Physiological Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State Animal Assisted Occupational Therapy - Minimally Conscious State | Not applicable | Recruiting | University of Basel | 26 | 2025-07-08 | 2025-12-18 |
| Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness tTIS - Disorders of Consciousness, Severe Brain Injury | Not applicable | Recruiting | Xijing Hospital | 10 | 2025-04-07 | 2025-04-09 |
| Prognostication of Recovery in Early Disorders of Consciousness Study Functional MRI (fMRI) - Disorder of Consciousness, Comatose | Not applicable | Enrolling by invitation | University of Pennsylvania | 150 | 2023-03-08 | 2026-07-30 |
| Eye Tracking Technology in the Diagnosis of Neurological Patients Postcomatose Unawareness State, Minimally Conscious State | Completed | AssisTech Sp. z o.o. | 90 | 2022-05-01 | 2023-07-20 | |
| Cerebellar iTBS in Patients With Disorders of Consciousness iTBS stimulation, sham stimulation - Disorder of Consciousness, Vegetative State | Not applicable | Unknown | Xijing Hospital | 44 | 2022-04-29 | 2022-09-28 |
| Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness Active taVNS, sham taVNS - Consciousness Disorder, Minimally Conscious State | Not applicable | Completed | University of Liege | 44 | 2022-02-09 | 2026-05-01 |
| Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility Study Transcranial direct current stimulation - Consciousness Disorder, Brain Injuries | Not applicable | Unknown | University of Birmingham | 15 | 2021-07-01 | 2021-05-03 |
| The Use of LIFUP in Chronic Disorders of Consciousness BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation - Disorder of Consciousness, Vegetative State | Not applicable | Completed | Casa Colina Hospital and Centers for Healthcare | 16 | 2021-06-21 | 2023-05-06 |
| Validation of the Chinese Version of the SECONDs Simplified Evaluation of CONsciousness Disorders (SECONDs) - Minimally Conscious State, Vegetative State | Not applicable | Completed | Hangzhou Normal University | 120 | 2020-11-10 | 2022-07-08 |
| Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires - Disorders of Consciousness, Minimally Conscious State | Unknown | Paris Brain Institute (ICM) | 150 | 2020-06-01 | 2021-03-15 | |
| Development of a Point of Care System for Automated Coma Prognosis Coma, Disorder of Consciousness | Unknown | McMaster University | 33 | 2019-10-01 | 2023-02-06 | |
| Closed-loop tDCS in Patients in Minimally Conscious State Anodal transcranial direct current stimulation - Minimally Conscious State | Not applicable | Completed | University of Liege | 16 | 2019-08-01 | 2026-05-06 |
| Therapeutic Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State Animal-assisted therapy, Conventional therapy - Minimally Conscious State | Not applicable | Completed | University of Basel | 30 | 2019-07-10 | 2025-08-13 |
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Persistent Vegetative State (45) · Consciousness Disorders (35) · Brain Injuries (11) · Coma (9) · Brain Injuries, Traumatic (7) · Cognitive Dysfunction (3) · Akinetic Mutism (1) · Cerebral Hemorrhage (1) · Coma, Post-Head Injury (1) · Disease (1) · Hypoxia (1) · Hypoxia, Brain (1) · Muscle Hypertonia (1) · Muscle Spasticity (1) · Nervous System Diseases (1)
Brain Damage, Chronic (45) · Brain Diseases (45) · Central Nervous System Diseases (45) · Neurobehavioral Manifestations (45) · Neurologic Manifestations (45) · Pathological Conditions, Signs and Symptoms (45) · Signs and Symptoms (45) · Unconsciousness (45) · Nervous System Diseases (44) · Mental Disorders (35) · Neurocognitive Disorders (35) · Craniocerebral Trauma (14) · Trauma, Nervous System (13) · Wounds and Injuries (13) · Consciousness Disorders (10)
Transcranial Direct Current Stimulation (9) · Animal Assisted Therapy (2) · Magnetic Resonance Imaging (2) · Amantadine (1) · Dexmedetomidine (1) · Diagnostic Imaging (1) · Midazolam (1) · Occupational Therapy (1) · Spinal Cord Stimulation (1) · Surveys and Questionnaires (1) · Transcranial Magnetic Stimulation (1)
Hangzhou Normal University (9) · University of Liege (7) · BDH-Klinik Hessisch Oldendorf (2) · University of Basel (2) · Xijing Hospital (2) · AssisTech Sp. z o.o. (1) · Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. (1) · Casa Colina Hospital and Centers for Healthcare (1) · Centre Hospitalier Universitaire de Liege (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Groupe Hospitalier Pitie-Salpetriere (1) · Hamilton Health Sciences Corporation (1) · Hospices Civils de Lyon (1) · Huashan Hospital (1) · IRCCS San Camillo, Venezia, Italy (1)
China (14) · Belgium (7) · Italy (5) · United States (4) · France (3) · Germany (3) · Canada (2) · Switzerland (2) · Brazil (1) · Cyprus (1) · Israel (1) · Poland (1) · South Korea (1) · United Kingdom (1)
Haibo Di, Pro. (4) · Haibo Di, Pro (3) · Alison Fox-Robichaud, MD (1) · Angela Morreale, MD (1) · Aurore Thibaut (1) · Aurore Thibaut, PhD (1) · Bartosz Kunka, Ph.D. (1) · Caroline Schnakers, PhD (1) · David J Fischer, MD (1) · Fanny Montulet (1) · Francesco Piccione, MD (1) · John F Connolly, PhD (1) · Lionel Naccache, MD PhD (1)
PMID 10869046, PMID 16369581, PMID 18005372, PMID 18484919, PMID 19188334, PMID 19947809, PMID 20376429, PMID 20647501, PMID 21112421, PMID 21283652, PMID 21876461, PMID 22156274, PMID 22224835, PMID 23341285, PMID 24574549, PMID 24988068, PMID 25613986, PMID 25690545, PMID 26745476, PMID 27567470, PMID 28901969, PMID 30405513, PMID 30777901, PMID 31320356, PMID 31401074, PMID 31798516, PMID 32919461, PMID 35250440, PMID 36467262, PMID 36494776, PMID 41419503, PMID 41484601, PMID 8291729
2019 (1), K23NS136745 (1)