12 completed, 4 not yet recruiting, 1 recruiting, 1 terminated. 6 Not applicable, 3 Phase 2, 3 Phase 4, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 3, Not yet recruiting 2, Unknown 1 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Minimal Hepatic Encephalopathy: new trials by email Literature Review of Minimal Hepatic Encephalopathy trials Research Report on Minimal Hepatic Encephalopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Electronic PHES vs Paper-based PHES for Hepatic Encephalopathy Paper-based Psychometric Hepatic Encephalopathy Score (PHES), Electronic Psychometric Hepatic Encephalopathy Score (PHES) - Liver Cirrhosis, Hepatic Encephalopathy | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 80 | 2026-10-01 | 2026-10-01 |
| A Prospective Cohort Study on the Epidemiological Investigation, Diagnosis, and Treatment of Hepatic Encephalopathy wechat mini-program - Hepatic Encephalopathy, Minimal Hepatic Encephalopathy | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 700 | 2026-10-01 | 2026-10-01 | |
| Equivalence of Electronic vs Paper-based PHES in Diagnosing Hepatic Encephalopathy Paper-based PHES, Electronic PHES - Liver Cirrhosis, Hepatic Encephalopathy (HE) | Not applicable | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 80 | 2026-10-01 | 2026-10-14 |
| Psychometric Hepatic Encephalopathy Score in Prediction of Minimal Hepatic Encephalopathy in Compensated Cirrhotic Patients Psychometric Hepatic Encephalopathy Score (PHES) - Minimal Hepatic Encephalopathy | Not yet recruiting | Sohag University | 150 | 2025-12-01 | 2025-12-09 | |
| BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE Oral Branched chain Amino acid, Rifaximin 550 MG, Lactulose - Hepatic Encephalopathy, Decompensated Cirrhosis | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 336 | 2025-02-01 | 2025-06-10 |
| Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility Rifaximin - Cirrhosis, Liver, Minimal Hepatic Encephalopathy | Phase 3 | Withdrawn | MetroHealth Medical Center | 2021-09-15 | 2025-12-24 | |
| A Study of MHE in Patients With Liver Diseases neurophysiological tests, blood biomarkers. - Hepatic Encephalopathy, Minimal Hepatic Encephalopathy | Completed | Qin Ning | 252 | 2019-05-01 | 2024-06-17 | |
| HEAL STUDY (Hepatic Encephalopathy and Albumin Study) 25% IV albumin, Placebo - Cirrhosis, Hepatic Encephalopathy | Phase 2 | Completed | Hunter Holmes Mcguire Veteran Affairs Medical Center | 48 | 2018-06-20 | 2022-05-31 |
| Transcranial Doppler Ultrasound and Minimal Hepatic Encephalopathy Rifaximin - Minimal Hepatic Encephalopathy | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 100 | 2018-01-18 | 2019-09-04 | |
| Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation Liver transplantation - Minimal Hepatic Encephalopathy | Completed | Ain Shams University | 40 | 2014-06-01 | 2016-05-11 | |
| Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate Vastus Muscle Biopsy, LOLA or placebo, Cognitive assessment (PHES) - Hepatic Encephalopathy, Minimal Hepatic Encephalopathy | Phase 4 | Completed | Imperial College London | 42 | 2013-08-01 | 2015-10-22 |
| Antioxidants and Zinc Improving Minimal Hepatic Encephalopathy In Truck Drivers; a Pilot Study 175 mg zinc gluconate, 50000 IU vitamin A, 500 mg vitamin C and 100 mg vitamin E once daily plus lactulose; dose 30-60 ml/day for 3 months, Lactulose - Minimal Hepatic Encephalopathy | Completed | Mansoura University | 58 | 2013-01-01 | 2015-08-13 | |
| Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy Auxiliary Treatment, Hyperproteic and fiber-rich diet, Nitazoxanide - Hepatic Cirrhosis, Minimal Hepatic Encephalopathy | Not applicable | Completed | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 60 | 2010-08-01 | 2014-08-20 |
| Study of Rifaximin in Minimal Hepatic Encephalopathy Rifaximin, rifaximin - Minimal Hepatic Encephalopathy | Phase 1 / Phase 2 | Completed | Hunter Holmes Mcguire Veteran Affairs Medical Center | 20 | 2010-02-01 | 2012-12-11 |
| Probiotic Lactobacillus GG (LGG) in Patients With Minimal Hepatic Encephalopathy Lactobacillus GG, Placebo - Minimal Hepatic Encephalopathy | Phase 1 | Completed | Virginia Commonwealth University | 37 | 2009-10-01 | 2014-01-07 |
| Study of Lactulose in Children With Chronic Liver Disease Lactulose, placebo - Minimal Hepatic Encephalopathy | Phase 2 | Terminated | Indiana University | 16 | 2009-01-01 | 2014-02-10 |
| A Nutritional Approach to Minimal Hepatic Encephalopathy Nutritional Intervention - Minimal Hepatic Encephalopathy | Not applicable | Unknown | Tel-Aviv Sourasky Medical Center | 60 | 2008-07-01 | 2010-03-09 |
| Effect of Yogurt on Minimal Hepatic Encephalopathy Yogurt Supplementation - Cirrhosis, Minimal Hepatic Encephalopathy | Not applicable | Completed | Medical College of Wisconsin | 30 | 2005-11-01 | 2007-11-01 |
| Effect of Lactulose on Minimal Hepatic Encephalopathy and Health-Related Quality of Life Lactulose - Minimal Hepatic Encephalopathy, Hepatic Encephalopathy | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 80 | 2004-01-01 | 2007-03-02 |
| Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy Acetyl-L-Carnitine, placebo - Minimal Hepatic Encephalopathy | Not applicable | Completed | University of Catania | 67 | 2002-04-01 | 2010-10-19 |
Hepatic Encephalopathy (9) · Liver Cirrhosis (6) · Fibrosis (5) · Brain Diseases (2) · Acute-On-Chronic Liver Failure (1) · Depression (1) · Disease (1) · Inflammation (1)
Central Nervous System Diseases (11) · Digestive System Diseases (11) · Liver Diseases (11) · Nervous System Diseases (11) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Brain Diseases (9) · Brain Diseases, Metabolic (9) · Hepatic Insufficiency (9) · Liver Failure (9) · Metabolic Diseases (9) · Nutritional and Metabolic Diseases (9) · Fibrosis (6) · Behavior (1) · Behavioral Symptoms (1)
Lactulose (4) · Rifaximin (4) · Acetylcarnitine (1) · Albumins (1) · Amino Acids, Branched-Chain (1) · Ascorbic Acid (1) · Blood Specimen Collection (1) · Liver Transplantation (1) · Nutrition Assessment (1) · Probiotics (1) · Spectrum Analysis (1) · Vitamin A (1) · gluconic acid (1) · nitazoxanide (1)
Hunter Holmes Mcguire Veteran Affairs Medical Center (2) · Post Graduate Institute of Medical Education and Research, Chandigarh (2) · The First Affiliated Hospital with Nanjing Medical University (2) · Ain Shams University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Imperial College London (1) · Indiana University (1) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (1) · Mansoura University (1) · Medical College of Wisconsin (1) · MetroHealth Medical Center (1) · Qin Ning (1) · Sohag University (1) · Tel-Aviv Sourasky Medical Center (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1)
United States (5) · China (3) · India (2) · Italy (2) · Egypt (1) · Israel (1) · Mexico (1) · United Kingdom (1)
Jasmohan S Bajaj, MD, MSc (2) · Aldo Torre-Delgadillo, MD (1) · Girish Subbarao, M.D. (1) · Jasmohan Bajaj, MD (1) · Jasmohan S Bajaj, MD (1) · Nachum Vaisman, Prof' (1) · Qin Ning, MD., PhD. (1) · Radha K Dhiman, MD,DM, FACG (1) · Ronnie Fass, MD (1) · Simon D Taylor-Robinson, MD FRCP (1)
PMID 26644276, PMID 17326150, PMID 19302262, PMID 20444959, PMID 20675008, PMID 20849805, PMID 21157444, PMID 23565181, PMID 25932262, PMID 31701074, PMID 34233031, PMID 36152764, PMID 38108656, PMID 38349709, PMID 39015557, PMID 41773757
U01AT004428 (1)