93 completed, 37 recruiting, 23 unknown, 11 terminated. 112 Not applicable, 15 Phase 2, 11 Phase 1, 4 Phase 3, 1 Early Phase 1.
Follow Mild Traumatic Brain Injury: new trials by email Literature Review of Mild Traumatic Brain Injury trials Research Report on Mild Traumatic Brain Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Sleep MAPP in the Polytrauma/TBI System of Care Sleep MAPP Care Pathway - Insomnia Disorder, Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | VA Office of Research and Development | 900 | 2027-01-01 | 2026-10-21 |
| Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury Crisis Response Planning - Mild Traumatic Brain Injury, Suicide Prevention | Not applicable | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 120 | 2026-12-01 | 2026-01-08 |
| Kids Injury Detection Study Using the i-STAT i-STAT TBI Cartridge with the i-STAT Alinity System - Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury | Not applicable | Not yet recruiting | Children's Healthcare of Atlanta | 700 | 2026-10-01 | 2026-09-23 |
| Evaluating Huddles as a Novel Approach to Improving Concussion Safety Pre-Game Safety Huddles - Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | Seattle Children's Hospital | 2000 | 2026-09-01 | 2026-03-20 |
| Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury Mindfulness-based intervention, Health Education - Brain Concussion, Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | Molly Cairncross | 72 | 2026-09-01 | 2026-07-13 |
| Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury Program 1, Program 2 - Mild Traumatic Brain Injury, Alexithymia | Not applicable | Recruiting | Hackensack Meridian Health | 300 | 2026-05-20 | 2026-06-12 |
| Improving Cognitive Rehabilitation Outcomes CCT+MBLT, CCT+ION - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder | Not applicable | Recruiting | VA Office of Research and Development | 144 | 2026-04-01 | 2026-04-24 |
| Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms Active tDCS, Sham tDCS - Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury | Not applicable | Recruiting | University of Minnesota | 30 | 2026-03-05 | 2026-09-01 |
| Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI) Cognitive behavioral Therapy for insomnia (CBT-I) - Sleep Architecture, Mild Traumatic Brain Injury | Not applicable | Recruiting | University of Missouri-Columbia | 15 | 2026-03-01 | 2026-05-01 |
| Multicenter Early Intervention Study in Adults With Complaints After Mild Traumatic Brain Injury Treatment by physical- and/or occupational therapist, Psychoeducation via telephonic counselling - Mild Traumatic Brain Injury | Not applicable | Recruiting | University Medical Center Groningen | 655 | 2026-02-16 | 2026-06-26 |
| Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury Passive neurosensory reintegration training (PNRT) - Mild Traumatic Brain Injury | Not applicable | Recruiting | University of Miami | 80 | 2025-12-15 | 2026-01-21 |
| Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI) - Mild Traumatic Brain Injury, Post Concussion Syndrome | Not applicable | Recruiting | University of Wisconsin, Madison | 55 | 2025-11-13 | 2026-05-06 |
| Concussion Recovery and Support Program CRISP (Concussion Recovery and Support Program) - Brain Concussion, Mild Traumatic Brain Injury | Not applicable | Recruiting | Seattle Children's Hospital | 40 | 2025-10-13 | 2025-11-18 |
| Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI) - Autonomic Nervous System Disease, Concussive Injury | Phase 2 / Phase 3 | Recruiting | Virginia Commonwealth University | 148 | 2025-09-02 | 2026-09-22 |
| REhabilitation of MEMory Symptoms After BRain Concussion Cognitive behavioral therapy, Cognitive rehabilitation - Concussion, Brain, Mild Traumatic Brain Injury | Not applicable | Recruiting | University of British Columbia | 184 | 2025-07-02 | 2026-06-02 |
| Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans Alpha neurofeedback training, Visual Attention Training - Traumatic Brain Injury, Mild Traumatic Brain Injury | Not applicable | Active not recruiting | University of Alabama at Birmingham | 36 | 2025-07-01 | 2026-08-07 |
| Pilot TMS in Mild TBI Intermittent theta burst stimulation - Persistent Post Concussive Headache, Mild Traumatic Brain Injury | Not applicable | Enrolling by invitation | HealthPartners Institute | 20 | 2025-06-18 | 2026-07-22 |
| Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging) - Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders | Recruiting | Assistance Publique Hopitaux De Marseille | 700 | 2025-05-19 | 2025-10-01 | |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
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Brain Concussion (185) · Brain Injuries, Traumatic (31) · Post-Concussion Syndrome (25) · Brain Injuries (15) · Stress Disorders, Post-Traumatic (14) · Cognitive Dysfunction (10) · Craniocerebral Trauma (7) · Depression (7) · Post-Traumatic Headache (7) · Headache (6) · Dizziness (5) · Emergencies (5) · Motor Activity (5) · Sleep Initiation and Maintenance Disorders (4) · Alcoholism (3)
Central Nervous System Diseases (185) · Head Injuries, Closed (185) · Nervous System Diseases (185) · Trauma, Nervous System (185) · Wounds and Injuries (185) · Wounds, Nonpenetrating (185) · Brain Diseases (184) · Craniocerebral Trauma (178) · Brain Injuries (170) · Brain Injuries, Traumatic (154) · Mental Disorders (36) · Pathological Conditions, Signs and Symptoms (30) · Signs and Symptoms (21) · Neurologic Manifestations (19) · Behavior (17)
Cognitive Behavioral Therapy (7) · Transcranial Magnetic Stimulation (4) · Cognitive Training (3) · Educational Status (3) · Acupuncture Therapy (2) · Blood Specimen Collection (2) · Creatine (2) · Docosahexaenoic Acids (2) · Memantine (2) · Mental Status and Dementia Tests (2) · Methods (2) · Standard of Care (2) · Therapeutics (2) · Transcranial Direct Current Stimulation (2) · erenumab (2)
VA Office of Research and Development (16) · University of British Columbia (8) · University of Calgary (6) · Children's Hospital of Philadelphia (5) · Henry M. Jackson Foundation for the Advancement of Military Medicine (4) · University of Miami (4) · ElMindA Ltd (3) · Holland Bloorview Kids Rehabilitation Hospital (3) · Oculogica, Inc. (3) · Oregon Health and Science University (3) · The University of Texas Health Science Center at San Antonio (3) · United States Naval Medical Center, San Diego (3) · University of Pittsburgh (3) · University of Texas Southwestern Medical Center (3) · First Affiliated Hospital Xi'an Jiaotong University (2)
United States (112) · Canada (32) · France (8) · Denmark (7) · Spain (4) · Australia (3) · China (3) · Norway (3) · Sweden (2) · Egypt (1) · Germany (1) · Iraq (1) · Italy (1) · Malaysia (1) · Monaco (1)
Noah Silverberg, PhD (5) · Amy A Herrold, PhD BA (3) · Christina Master, MD (3) · David L Brody, MD, PhD (3) · David X Cifu, MD (3) · Anthony P Kontos, PhD (2) · Craig Donaldson, MBBS (2) · Hana M Rytter (2) · Lars D Hungerford, PhD (2) · Michael Hoffer, MD (2) · Rosina Samadani, PhD (2) · William C Walker, MD (2) · Adam R. Kinney, PhD OTR (1) · Alexandra L Aaronson, MD (1)
PMID 12924684, PMID 12964174, PMID 19387313, PMID 23372680, PMID 25560444, PMID 25702209, PMID 26176913, PMID 26231756, PMID 26537996, PMID 27479847, PMID 27766587, PMID 27792852, PMID 28314862, PMID 28365025, PMID 29157025, PMID 29292069, PMID 29294714, PMID 29873292, PMID 30535623, PMID 30975680, PMID 30975684, PMID 31246882, PMID 31368742, PMID 31442093, PMID 31518280, PMID 31530227, PMID 31537559, PMID 31551902, PMID 31737275, PMID 31771689, PMID 31924681, PMID 31951263, PMID 32024486, PMID 32032736, PMID 32387427, PMID 32493206, PMID 32567875, PMID 33192959, PMID 33201041, PMID 33228537, PMID 33242991, PMID 33481332, PMID 33519659, PMID 33632753, PMID 33656471, PMID 33656475, PMID 34009790, PMID 34253715, PMID 34410757, PMID 34600629
2018 (2), 1IK2RX001136-01A2 (1), 2016 (1), I01RX000825 (1), I01RX001106 (1), I01RX002916 (1), I21RX003611 (1), IK2RX000949 (1), K23NS128275 (1), P30AG048785 (1), R01AG076441 (1), R01EY023261 (1), R01NS129617 (1), R15DC015338 (1), R15MH136612 (1)