625 completed, 238 unknown, 171 recruiting, 57 active not recruiting. 725 Not applicable, 139 Phase 2, 68 Phase 1, 37 Phase 4, 23 Phase 3.
Follow Mild Cognitive Impairment: new trials by email Literature Review of Mild Cognitive Impairment trials Research Report on Mild Cognitive Impairment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog Assessments, Neuroimaging volumetric measures, Biofluid samples - Mild Cognitive Impairment, Subjective Cognitive Decline | Enrolling by invitation | Ohio State University | 100 | 2027-03-01 | 2026-10-16 | |
| Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E) Mild Cognitive Impairment, Memory Disorders | Not yet recruiting | Don Mottola Medical Center | 1000 | 2027-01-20 | 2026-11-05 | |
| A Mobile Informatics Solution to Assist Caregivers in Care Coordination and Monitoring Social Engagement Social Reminder System - Memory Disorders, Mild Cognitive Impairment | Not applicable | Not yet recruiting | University of Minnesota | 200 | 2027-01-16 | 2026-11-04 |
| SleepSMART for Veterans With Insomnia and Mild Cognitive Impairment Cognitive BehavioralTherapy for Insomnia (CBT-I), SleepSMART - Insomnia, Mild Cognitive Impairment | Not applicable | Not yet recruiting | VA Office of Research and Development | 150 | 2027-01-05 | 2026-11-09 |
| Gaze and Gait Training With rTMS Repetitive Transcranial Magnetic Stimulation (rTMS), Gait training, Gaze training - Mild Cognitive Impairment | Not applicable | Not yet recruiting | University of Florida | 30 | 2027-01-01 | 2026-05-06 |
| Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns High-frequency Transcranial Magnetic Stimulation (TMS), Digital Cognitive Training, Structured Physical Exercise - Subjective Cognitive Decline, Alzheimer Disease | Not applicable | Not yet recruiting | IRCCS San Raffaele | 300 | 2026-12-01 | 2026-11-10 |
| PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI) 18F-PF974, 18F-florbetaben - Alzheimer s Disease, Mild Cognitive Impairment | Phase 1 | Recruiting | National Institute of Mental Health (NIMH) | 90 | 2026-11-18 | 2026-11-13 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1 Project 1 - Phase 2: VR Program for Social, Activity, and Cognitive Engagement, Project 1 - Phase 2: Tablet for Social, Activity, and Cognitive Engagement - Mild Cognitive Impairment | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 108 | 2026-10-31 | 2026-08-20 |
| Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2 Project 2, Phase 2: Intelligent Adaptive System - Mild Cognitive Impairment | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 120 | 2026-10-31 | 2026-08-17 |
| Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT Feeling of Being, Health Enhancement Program - Chronic Pain, Mild Cognitive Impairment | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-10-18 | 2026-08-25 |
| Superior Parietal iTBS for PD-MCI Accelerated intermittent theta-burst stimulation (iTBS) rTMS to right superior parietal lobule (rSPL) - Parkinson Disease, Mild Cognitive Impairment | Not applicable | Recruiting | Medical University of South Carolina | 30 | 2026-10-09 | 2026-10-14 |
| Choose Myself (Before) Losing Myself CYOA booklet - Dementia (Diagnosis), Mild Cognitive Impairment | Not applicable | Recruiting | The Cleveland Clinic | 25 | 2026-10-09 | 2026-10-22 |
| Virtual Outreach and Individualized Coaching Extension Virtual Outreach and Individualized Coaching Extension - Chronic Disease, Mild Cognitive Impairment | Not applicable | Not yet recruiting | Emory University | 50 | 2026-10-01 | 2026-09-23 |
| Jigsawdio Multisensory Platform for People With Mild Cognitive Impairment, Alzheimer's Disease, or Related Dementias Jigsawdio Multisensory Puzzle Platform, Standard Jigsaw Puzzle Activity - Alzheimer Disease, Dementia | Not applicable | Not yet recruiting | Callahan-Young LLC DBA Jigsawdio | 80 | 2026-10-01 | 2026-09-25 |
| Improving Neurological Health With Acetylcholine Via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impairment Computerized speed-based cognitive training, Computerized executive function cognitive training - Mild Cognitive Impairment | Not applicable | Recruiting | Posit Science Corporation | 84 | 2026-09-25 | 2026-09-21 |
| Brain Heath Service for Prevention of AD medical referral and/or educational programs - Alzheimer, Cognitive Unimpaired | Not applicable | Enrolling by invitation | Chinese University of Hong Kong | 4000 | 2026-09-21 | 2026-10-22 |
| Effects of an Exercise Snacking Intervention on Cognitive Function in Patients With Mild Cognitive Impairment: A Nationwide Multicenter Randomized Controlled Trial Baduanjin-Based Exercise Snacking - Mild Cognitive Impairment | Not applicable | Not yet recruiting | Peking University | 240 | 2026-09-15 | 2026-09-16 |
| VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism Multimodal visuospatial and topographical memory assessment - Parkinson's Disease, Parkinsonism | Not yet recruiting | IRCCS San Raffaele Roma | 80 | 2026-09-01 | 2026-09-18 | |
| PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehabilitation in Adults PhiCube, Conventional rehabilitation - Stroke, Parkinson Disease | Not applicable | Not yet recruiting | Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato | 80 | 2026-09-01 | 2026-10-08 |
| 2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients 2-hydroxybenzylamine acetate, Placebo - Alzheimer Disease, Mild Cognitive Impairment | Phase 1 / Phase 2 | Not yet recruiting | MTI Biotech Inc | 48 | 2026-09-01 | 2026-09-24 |
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Cognitive Dysfunction (1238) · Alzheimer Disease (451) · Dementia (245) · Memory Disorders (62) · Motor Activity (60) · Parkinson Disease (55) · Dementia, Vascular (38) · Neurocognitive Disorders (33) · Depression (31) · Lewy Body Disease (31) · Cognition Disorders (23) · Disease (19) · Lymphoma, Follicular (19) · Neurodegenerative Diseases (18) · Diabetes Mellitus, Type 2 (16)
Mental Disorders (1234) · Cognition Disorders (1215) · Neurocognitive Disorders (1205) · Nervous System Diseases (665) · Central Nervous System Diseases (620) · Brain Diseases (612) · Neurodegenerative Diseases (474) · Tauopathies (443) · Dementia (319) · Pathological Conditions, Signs and Symptoms (210) · Signs and Symptoms (136) · Behavior (131) · Neurologic Manifestations (122) · Neurobehavioral Manifestations (93) · Basal Ganglia Diseases (81)
Cognitive Training (35) · Exercise (35) · Transcranial Direct Current Stimulation (31) · Control Groups (18) · Transcranial Magnetic Stimulation (18) · Donepezil (11) · Magnetic Resonance Spectroscopy (10) · Neuropsychological Tests (9) · florbetapir (8) · Insulin (7) · Metformin (7) · Tablets (7) · Diet, Mediterranean (6) · Therapeutics (6) · flutemetamol (6)
VA Office of Research and Development (19) · Massachusetts General Hospital (17) · Wake Forest University Health Sciences (15) · Chang Gung Memorial Hospital (14) · Emory University (14) · Johns Hopkins University (14) · The University of Hong Kong (13) · University of California, San Francisco (13) · Icahn School of Medicine at Mount Sinai (12) · Indiana University (12) · Mayo Clinic (11) · University of Michigan (11) · University of Pennsylvania (11) · Riphah International University (10) · University of British Columbia (10)
United States (554) · Canada (78) · China (62) · Italy (52) · Taiwan (44) · Spain (43) · South Korea (41) · United Kingdom (37) · Hong Kong (30) · France (29) · Switzerland (28) · Germany (23) · Netherlands (20) · Israel (19) · Singapore (16)
Suzanne Craft, PhD (14) · Mariana Figueiro, PhD (8) · Emil Fristed, MSc (7) · Cay Anderson-Hanley, PhD (5) · Katherine Turk, MD (4) · Ki Woong Kim, M.D., Ph.D. (4) · Paul Aisen, MD (4) · Teresa Liu-Ambrose, PhD (4) · Ana-Maria Vranceanu, PhD (3) · Benjamin M. Hampstead, PhD (3) · Davangere Devanand, M.D. (3) · Erik Stomrud, MD, PhD (3) · Murali Doraiswamy, MD (3)
PMID 29780318, PMID 30200183, PMID 30233154, PMID 15817019, PMID 22261206, PMID 27337738, PMID 27472878, PMID 29331848, PMID 29500313, PMID 30618593, PMID 30989165, PMID 31221697, PMID 34366147, PMID 38720025, PMID 40049590, PMID 40090784, PMID 41639807, PMID 10398352, PMID 10651933, PMID 12053639, PMID 12547745, PMID 12843299, PMID 14663030, PMID 15563720, PMID 15650460, PMID 15650465, PMID 15701227, PMID 16120771, PMID 16469995, PMID 16552413, PMID 16702783, PMID 16821201, PMID 17060562, PMID 17785667, PMID 17881514, PMID 18047442, PMID 18381770, PMID 18400101, PMID 18611150, PMID 18625866, PMID 18771388, PMID 18854539, PMID 19049544, PMID 19162077, PMID 19198615, PMID 19376977, PMID 19506141, PMID 19524846, PMID 19560102, PMID 19689233
2018 (4), U54AG063546 (4), 2016 (3), 2SB1AG059458-04A1 (3), P01AG073090 (3), 2017 (2), P30AG022849 (2), P50AG005136 (2), R01AG058724 (2), R01MH114966 (2), R01MH114970 (2), R01MH114980 (2), R01MH114981 (2), R01NR015452 (2), U24AT012601 (2)