9 completed, 4 recruiting, 2 terminated, 2 unknown. 7 Not applicable, 2 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 3, Recruiting 3, Terminated 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Terminated 1 |
| Phase 4 | 1 | Completed 1 |
Follow Familial cyclic vomiting syndrome: new trials by email Literature Review of Familial cyclic vomiting syndrome trials Research Report on Familial cyclic vomiting syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Auricular Neurostimulation for Children With Cyclic Vomiting Syndrome Active percutaneous electrical nerve field stimulation, Sham percutaneous electrical nerve field stimulation - Cyclic Vomiting Syndrome | Not applicable | Recruiting | Medical College of Wisconsin | 120 | 2026-02-11 | 2026-03-16 |
| Autonomic Reactivity and Personalized Neurostimulation Percutaneous electrical nerve field stimulation, Hypnotherapy - Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome | Not applicable | Recruiting | Medical College of Wisconsin | 120 | 2025-01-24 | 2026-02-13 |
| Validation of a Mental Health Scale for Young People With Chronic Stomach Symptoms Functional Gastrointestinal Disorders, Gastroparesis | Unknown | Greg O'Grady | 100 | 2024-05-01 | 2024-05-02 | |
| Body Surface Gastric Mapping to Evaluate Patients With Upper Gastrointestinal Symptoms and Controls Gastric Alimetry System - Motility Disorder, Gastroparesis | Enrolling by invitation | University of Calgary | 400 | 2022-11-01 | 2026-10-15 | |
| Heartfulness Meditation (HFM) in Cyclic Vomiting Syndrome (CVS) Heartfulness meditation - Cyclic Vomiting Syndrome | Not applicable | Completed | Ohio State University | 45 | 2022-06-06 | 2025-02-14 |
| Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants. Questionnaire, clinical examination - Functional Gastrointestinal Disorders, Gastroesophageal Reflux | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 71 | 2022-05-20 | 2025-03-11 | |
| Cortical Excitability in Cyclic Vomiting Syndrome TMS Paired-Pulse assessment of cortical excitability, Autonomic activity - Cyclic Vomiting Syndrome | Not applicable | Recruiting | University of Pittsburgh | 110 | 2022-05-16 | 2026-08-14 |
| Haloperidol, Droperidol, Ondansetron in Cannabis Hyperemesis Droperidol, Haloperidol, Ondansetron 8mg - Cyclic Vomiting Syndrome | Phase 3 | Terminated | Corewell Health South | 32 | 2021-08-30 | 2025-05-21 |
| Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome 3mg AZ-010, 1mg AZ010, Staccato Placebo - Cyclic Vomiting Syndrome | Phase 2 | Completed | Alexza Pharmaceuticals, Inc. | 150 | 2021-02-05 | 2025-06-11 |
| Effectiveness of Electrical Neurostimulation in Cyclic Vomiting Syndrome. The Bridge device - Cyclic Vomiting Syndrome | Not applicable | Terminated | Medical College of Wisconsin | 4 | 2019-04-23 | 2026-04-02 |
| Applying Nutrient Drink Test in Understanding Pathophysiology of CVS Ensure - Cyclic Vomiting Syndrome | Completed | The Cleveland Clinic | 24 | 2018-02-01 | 2020-02-27 | |
| Auricular Neurostimulation for Cyclic Vomiting Syndrome Percutaneous neurostimulation - Cyclic Vomiting Syndrome, Abdominal Migraine | Not applicable | Completed | Medical College of Wisconsin | 47 | 2018-01-31 | 2026-02-13 |
| Non Contrast MRI in Lower Extremity Venous Insufficiency of Leg, Venous Leg Ulcer | Unknown | Chang Gung Memorial Hospital | 300 | 2018-01-01 | 2021-08-09 | |
| Topical Capsaicin for Cyclical Vomiting Capsaicin 0.1% Cream, Placebos - Cyclical Vomiting | Phase 2 | Completed | Henry Ford Health System | 30 | 2017-12-20 | 2021-12-15 |
| Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) Ondansetron 8mg, Haloperidol 0.05mg/kg, Haloperidol 0.1mg/kg - Cannabis Use Disorder | Phase 4 | Completed | Dr. Marco L.A. Sivilotti | 33 | 2017-05-21 | 2024-04-03 |
| Analysis of Q10 Coenzyme Efficacy for Long-term Treatment of Cyclic Vomiting Syndrome in Children Q10 Coenzyme - Cyclic Vomiting Syndrome | Completed | Central Hospital, Nancy, France | 15 | 2016-12-01 | 2017-09-28 | |
| Effects of an Integrative Health Care Model With Meditation and Care Cordination in CVS Integrative healt care - Cyclic Vomiting Syndrome | Not applicable | Completed | Medical College of Wisconsin | 74 | 2016-10-05 | 2020-04-01 |
| Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Irritable Bowel Syndrome, Cyclical Vomiting Syndrome | Completed | University of California, Los Angeles | 165 | 2011-03-01 | 2016-01-14 | |
| The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS) Cyclic Vomiting Syndrome | Withdrawn | Medical College of Wisconsin | 2007-10-01 | 2017-02-06 |
Gastrointestinal Diseases (3) · Gastroesophageal Reflux (2) · Gastroparesis (2) · Migraine Disorders (2) · Nausea (2) · Vomiting (2) · Abdominal Pain (1) · Aerophagy (1) · Autonomic Nervous System Diseases (1) · Cannabinoid Hyperemesis Syndrome (1) · Colic (1) · Colitis, Ulcerative (1) · Constipation (1) · Crohn Disease (1)
Digestive System Diseases (6) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Signs and Symptoms, Digestive (4) · Chemically-Induced Disorders (3) · Gastrointestinal Diseases (3) · Mental Disorders (3) · Nervous System Diseases (3) · Neurologic Manifestations (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Deglutition Disorders (2) · Esophageal Diseases (2) · Esophageal Motility Disorders (2) · Female Urogenital Diseases and Pregnancy Complications (2)
Haloperidol (2) · Ondansetron (2) · Capsaicin (1) · Droperidol (1) · Hypnosis (1) · Restraint, Physical (1) · Surveys and Questionnaires (1) · Ubiquinone (1)
Medical College of Wisconsin (6) · Alexza Pharmaceuticals, Inc. (1) · Central Hospital, Nancy, France (1) · Chang Gung Memorial Hospital (1) · Corewell Health South (1) · Dr. Marco L.A. Sivilotti (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Greg O'Grady (1) · Henry Ford Health System (1) · Ohio State University (1) · The Cleveland Clinic (1) · University of Calgary (1) · University of California, Los Angeles (1) · University of Pittsburgh (1)
United States (12) · Canada (2) · France (1) · Italy (1) · Taiwan (1)
B Li, MD (1) · Christopher N Andrews, MD MSc FRCPC (1) · David J Levinthal, MD PhD (1) · Emeran Mayer, MD (1) · Gila Ginzburg, MD (1) · Joseph Miller, MD (1) · Katja Karrento, MD (1) · Katja Kovacic, MD (1) · Larry Carter, PhD (1) · Marco LA Sivilotti, MD, MSc (1) · Scott Gabbard, MD (1) · Stefano Nobile, MD, PhD, MSc (1) · Thangam Venkatesan (1)
PMID 15893282, PMID 27144631, PMID 29398057, PMID 32446468, PMID 33160719, PMID 36705695, PMID 37389229, PMID 38713142, PMID 42056628
R01DK140255 (1)