19 completed, 4 terminated, 1 recruiting. 24 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 24 | Completed 19, Terminated 4, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Mania: new trials by email Literature Review of Mania trials Research Report on Mania
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current Mania NBI-1117568, Placebo - Bipolar I Disorder, Mania | Phase 2 | Recruiting | Neurocrine Biosciences | 150 | 2025-12-24 | 2026-09-29 |
| Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Bipolar I Disorder RAP-219, Placebo - Bipolar 1 Disorder | Phase 2 | Completed | Rapport Therapeutics Inc. | 253 | 2025-07-25 | 2026-10-26 |
| BHV-7000 Open-Label Extension Bipolar Mania Study BHV-7000 - Bipolar Disorder | Phase 2 | Terminated | Biohaven Therapeutics Ltd. | 94 | 2024-06-24 | 2025-12-16 |
| BHV-7000 Acute Treatment of Bipolar Mania BHV-7000, Placebo - Bipolar Disorder | Phase 2 / Phase 3 | Completed | Biohaven Therapeutics Ltd. | 274 | 2024-05-28 | 2025-12-16 |
| Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania OMega 3, Placebo - Mania | Phase 2 | Completed | University of Cincinnati | 55 | 2009-06-01 | 2019-11-13 |
| Efficacy and Safety of Lu AA39959 in Patients With Bipolar Depression Lu AA39959, Placebo, Quetiapine - Bipolar Disorder | Phase 2 | Terminated | H. Lundbeck A/S | 105 | 2008-12-01 | 2014-05-28 |
| Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder Riluzole - Bipolar Disorder, Anxiety Disorders | Phase 2 | Terminated | National Institute of Mental Health (NIMH) | 6 | 2008-11-01 | 2017-09-15 |
| Efficacy and Safety of Lu AA34893 in Patients With Bipolar Depression Lu AA34893, Quetiapine fumarate, Placebo - Depression in Patients With Bipolar Disorder | Phase 2 | Terminated | H. Lundbeck A/S | 166 | 2008-01-01 | 2010-09-27 |
| Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute Mania Cariprazine (RGH-188), Placebo - Bipolar Disorder | Phase 2 | Completed | Forest Laboratories | 238 | 2007-06-01 | 2017-04-14 |
| Effects of Pentazocine Versus Lorazepam on Manic Symptoms Pentazocine, Lorazepam - Bipolar Disorder, Schizoaffective Disorder | Phase 2 | Completed | Mclean Hospital | 19 | 2007-01-01 | 2019-03-06 |
| Lithium for the Treatment of Pediatric Mania Lithium Carbonate, Placebo - Bipolar I Disorder Without Psychotic Symptoms | Phase 2 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 61 | 2006-12-01 | 2012-02-28 |
| Safety and Efficacy of MEM 1003 Versus Placebo for the Treatment of Patients With Bipolar I Disorder MEM 1003 - Bipolar Disorder With Manic or Mixed Episodes | Phase 2 | Completed | Memory Pharmaceuticals | 60 | 2006-09-01 | 2008-05-06 |
| Open Label Trial of Acamprosate in Bipolar Alcoholics Acamprosate - Alcohol Dependence, Bipolar Disorder | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 9 | 2006-04-01 | 2008-09-19 |
| Effects of Pentazocine on Manic Symptoms Talwin Nx - Bipolar Disorder | Phase 2 | Completed | Mclean Hospital | 10 | 2005-09-01 | 2014-09-04 |
| Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study taurine - Bipolar Disorder, Mania | Phase 2 | Completed | Mclean Hospital | 60 | 2005-04-01 | 2019-03-01 |
| An Evaluation of the Safety and Efficacy of Memantine in Patients With Acute Mania Associated With Bipolar I Disorder Memantine HCl - Bipolar Disorder | Phase 2 | Completed | Forest Laboratories | 35 | 2005-02-01 | 2012-03-05 |
| Cytidine and Omega-3 Fatty Acids in Bipolar Disorder cytidine, omega-3 fatty acids, placebo - Bipolar Disorder | Phase 2 | Completed | Mclean Hospital | 90 | 2004-07-01 | 2012-04-20 |
| Escitalopram as a Mood Stabilizer for Bipolar II Disorder Escitalopram (Lexapro) - Bipolar Disorders | Phase 2 | Completed | The University of New South Wales | 10 | 2004-02-01 | 2006-01-02 |
| Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women? Tamoxifen, Progesterone, placebo - Bipolar Disorder, Mania | Phase 2 | Completed | The Alfred | 51 | 2004-01-01 | 2008-10-24 |
| Clozapine for Treatment-Resistant Mania Clozapine - Bipolar Disorder | Phase 2 | Completed | National Institute of Mental Health (NIMH) | 42 | 2002-01-01 | 2008-03-04 |
Showing 20 of 24. Sign in to see all of them.
Bipolar Disorder (19) · Depression (9) · Mood Disorders (3) · Psychotic Disorders (3) · Anxiety Disorders (2) · Alcoholism (1) · Behavior, Addictive (1) · Depressive Disorder (1) · Impulsive Behavior (1) · Substance-Related Disorders (1)
Nervous System Diseases (24) · Neurobehavioral Manifestations (24) · Neurologic Manifestations (24) · Pathological Conditions, Signs and Symptoms (24) · Signs and Symptoms (24) · Bipolar and Related Disorders (19) · Mental Disorders (19) · Mood Disorders (16) · Behavior (9) · Behavioral Symptoms (9) · Schizophrenia Spectrum and Other Psychotic Disorders (3) · Alcohol-Related Disorders (1) · Chemically-Induced Disorders (1) · Compulsive Behavior (1)
Pentazocine (2) · Quetiapine Fumarate (2) · Tamoxifen (2) · talwin Nx (2) · Acamprosate (1) · Clozapine (1) · Cytidine (1) · Docosahexaenoic Acids (1) · Escitalopram (1) · Fatty Acids, Omega-3 (1) · Fish Oils (1) · Gabapentin (1) · Lamotrigine (1) · Levetiracetam (1) · Lithium Carbonate (1)
National Institute of Mental Health (NIMH) (6) · Mclean Hospital (4) · Biohaven Therapeutics Ltd. (2) · Forest Laboratories (2) · H. Lundbeck A/S (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Medical University of South Carolina (1) · Memory Pharmaceuticals (1) · Neurocrine Biosciences (1) · Rapport Therapeutics Inc. (1) · The Alfred (1) · The University of New South Wales (1) · University of Cincinnati (1)
United States (20) · Australia (3) · Austria (1) · Belgium (1) · Bulgaria (1) · Canada (1) · France (1) · Germany (1) · Lithuania (1) · Malaysia (1) · Philippines (1) · Poland (1) · Romania (1) · Slovakia (1) · South Korea (1)
Beth L Murphy, MD, PhD (3) · Beth L Murphy, MD/PhD (1) · Bryan K. Tolliver, M.D., Ph.D. (1) · Edwin A Gomez, MD (1) · Ellen Leibenluft, MD (1) · Gordon Parker (1) · Jayashri Kulkarni, MBBS, MPM, FRANZCP, PhD (1) · Kathleen T. Brady, M.D., Ph.D. (1) · Melissa DelBello, MD (1) · Robert L Findling, MD (1) · Robert McNamara, PhD (1) · Stephen R Murray, MD, PhD (1)
PMID 17897484, PMID 18700004, PMID 22926607, PMID 29017067, PMID 30738555, PMID 31344528
K24DA000435 (1)